Results 21 to 30 of about 26,991 (196)

Plasma clearance and biodistribution of oxidatively modified 99mTc-ß-VLDL in rabbits

Brazilian Journal of Medical and Biological Research, 1997
The biodistribution and removal from plasma (measured as fractional clearance rate, FCR, per hour) of native and oxidatively modified 99mtechnetium-labeled ß-very low density lipoprotein (99mTc-ß-VLDL) were investigated in hypercholesterolemic (HC) and ...
E.L. Silva, J.C. Meneghetti, I.J.C Coelho, D.S.P Abdalla   +3 more
doaj   +1 more source

Detection Performance of 99mTc in Albira SI Small-Animal SPECT-CT

Journal of Isotopes
Small-animal single-photon emission computed tomography-X-ray computed tomography (SPECT-CT) is an advanced imaging tool for preclinical research of single-photon radiopharmaceuticals.
Jie TANG, Dong XU, Qianyue HU, Bo ZHANG, Wei LI, Lizhen WANG, Huixin YU, Fukuan ZHAO   +7 more
doaj   +1 more source

Precision Oncology via Radiotherapy‐Triggered Drug Delivery: Mechanisms, Molecular Engineering, and Clinical Translation

Advanced Science, EarlyView.
This review redefines radiotherapy‐triggered drug delivery systems through structural disassembly and molecular actuation, proposing a translation‐oriented framework for dose‐correlated activation to advance clinically integrated precision oncology. ABSTRACT Radiotherapy‐triggered drug delivery systems (RDDS) promise to integrate the spatial precision ...
Jianv Jiang, Tanfeng Zhang, Junliang Dong, Wenjing Sun   +3 more
wiley   +1 more source

Development of 99Mo/99mTc Generator System for Production of Medical Radionuclide 99mTc using a Neutron-activated 99Mo and Zirconium Based Material (ZBM) as its Adsorbent

Atom Indonesia, 2016
Molybdenum produced from fission of U-235 is the most desirable precursor for 99Mo/99mTc generator system as it is non-carrier added and has high specific activity. However, in the last decade there has been short supply of 99Mo due to several constrains.
I. Saptiama, E. Lestari, E. Sarmini, H. Lubis, Marlina, A. Mutalib   +5 more
doaj   +1 more source

166Holmium–99 mTechnetium dual-isotope imaging: scatter compensation and automatic healthy-liver segmentation for 166Holmium radioembolization dosimetry

EJNMMI Physics, 2022
Background Partition modeling allows personalized activity calculation for holmium-166 (166Ho) radioembolization. However, it requires the definition of tumor and non-tumorous liver, by segmentation and registration of a separately acquired CT, which is ...
Martina Stella, Arthur J. A. T. Braat, Marnix G. E. H. Lam, Hugo W. A. M. de Jong, Rob van Rooij   +4 more
doaj   +1 more source

Recent Advances in Functional Liver Volumetry: Emphasis on 99mTc‐GSA SPECT/CT Fusion Imaging

Annals of Gastroenterological Surgery, EarlyView.
Functional liver volumetry enables more accurate assessment of the future liver remnant by integrating anatomical and functional information, improving risk stratification before major hepatectomy. Among available techniques, 99mTc‐GSA SPECT/CT fusion imaging enables precise regional functional assessment and more reliable prediction of post ...
Toru Beppu, Toshiro Masuda, Yasunori Nagayama, Hidetoshi Nitta, Hiromitsu Hayashi   +4 more
wiley   +1 more source

Affibody-based molecular probe 99mTc-(HE)3ZHER2:V2 for non-invasive HER2 detection in ovarian and breast cancer xenografts

Open Medicine
This study aimed to assess the biodistribution and bioactivity of the affibody molecular probe 99mTc-(HE)3ZHER2:V2, prepared by genetic recombination, and to investigate its potential for targeted human epidermal growth factor receptor 2 (HER2) imaging ...
Hu Xianwen, Hu Hongyu, Li Dandan, Wang Pan, Cai Jiong   +4 more
doaj   +1 more source

New amino bisphosphonate compound for skeletal imaging: Comparison study with methylenediphosphonic acid (MDP) and (1-hydroxyethane-1,1-diyl) diphosphonic acid (HEDP)

Nukleonika, 2016
A novel bisphosphonate derivative (1-aminoethane-1,1-diyl)diphosphonic acid (AEDP) has been prepared and successfully labeled with 99mTc at high labeling yields.
Assaad Thaer
doaj   +1 more source

Biodistribution of 99mTc-GE11 molecular probe and receptor imaging in nude mice bearing lung adenocarcinoma

Di-san junyi daxue xuebao, 2019
Objective To prepare a 99mTc-labled molecular probe (99mTc-GE11) targeting epidermal growth factor receptor (EGFR) on lung adenocarcinoma cells and evaluate its biodistribution and performance for EGFR imaging in nude mice bearing lung adenocarcinoma ...
TAN Zuwen, WU Mengxue, LI Yunjie, LEI Chengming, DENG Jie, DUAN Dong   +5 more
doaj   +1 more source

Synthesis and preclinical evaluation of novel 99mTc-labeled PSMA ligands for radioguided surgery of prostate cancer

EJNMMI Research, 2023
Background Radioguided surgery (RGS) has recently emerged as a valuable new tool in the management of recurrent prostate cancer (PCa). After preoperative injection of a 99mTc-labeled prostate-specific membrane antigen (PSMA) inhibitor, radioguided ...
Jan-Philip Kunert, Max Müller, Thomas Günther, León Stopper, Nicole Urtz-Urban, Roswitha Beck, Hans-Jürgen Wester   +6 more
doaj   +1 more source