Results 31 to 40 of about 26,991 (196)

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

Prevalence of transthyretin cardiac amyloidosis in undifferentiated heart failure with preserved ejection fraction

ESC Heart Failure, Volume 12, Issue 2, Page 1176-1182, April 2025.
Abstract Aims Transthyretin amyloid cardiomyopathy (ATTR‐CM) is an increasinglyrecognized cause of heart failure with preserved ejection fraction (HFpEF), which may be diagnosed non‐invasively using 99mTc 3,3‐diphosphono‐1,2‐propanodicarboxylic acid (DPD) scintigraphy‐based diagnostic criteria.
L. Healy, G. Giblin, A. Gray, N. Starr, L. Murphy, D. O'Sullivan, E. Kavanagh, C. Howley, C. Tracey, E. Morrin, A. McDaid, A. Clarke, J.O. O'Neill, E. Joyce, M. O'Connell, N. G. Mahon   +15 more
wiley   +1 more source

Research on the Preparation of Irradiated-type 99Mo-99mTc Generator

Journal of Isotopes
Due to the excellent nuclear properties，99mTc has been used in the field of early diagnosis of tumor and nuclear medicine imaging. As the most widely applied radioisotope，it accounts for more than 70% of the market of total radioisotopes used in the ...
Siwei GU, Ning LUO, Bo LI, Qinzhi LI, Yingjiang HU, Yunming CHEN, Jinsong ZHANG   +6 more
doaj   +1 more source

Transendocardial injection of expanded autologous CD34+ cells after myocardial infarction: Design of the EXCELLENT trial

ESC Heart Failure, Volume 12, Issue 2, Page 1455-1463, April 2025.
Abstract Aims The extent of irreversible cardiomyocyte necrosis after acute myocardial infarction (AMI) is a major determinant of residual left ventricular (LV) function and clinical outcome. Cell therapy based on CD34+ cells has emerged as an option to help repair the myocardium and to improve outcomes.
Jerome Roncalli, François Roubille, Nicolas Meyer, Giulio Pompilio, Lionel Leroux, Philippe Henon, Guillaume Trebuchet, Anthony Criquet, Matthieu de Kalbermatten, Eric Saloux, Alain Manrique, Pierre‐Yves Marie, Deepak L. Bhatt, Scott D. Solomon, Gilles Montalescot, David E. Newby, Faiez Zannad, on behalf of the EXCELLENT Trial Investigators   +17 more
wiley   +1 more source

99mTc-MIBI Scintigraphy to differentiate malignancies from benign lesions detected on Planar bone scans

The Egyptian Journal of Radiology and Nuclear Medicine, 2016
The aim of study was to evaluate the effectiveness of 99mTc-MIBI (hexakis 2-methoxyisobutyl isonitrile) scintigraphy to differentiate malignant from benign lesions, detected on 99mTc-MDP planar bone scans.
Aniqa Jabeen, Hassan Raza, Bashir Ahmed, S. Minhaj Maqbool, Sumaira Mushtaq, Lubna Khan Jadoon, Mussaratulain, Mohammd Ali Memon   +7 more
doaj   +1 more source

99mTc-MIBI uptake as a marker of mitochondrial membrane potential in cancer cells and effects of MDR1 and verapamil.

PLoS ONE, 2020
We investigated the relation of 99mTc-MIBI uptake to mitochondrial membrane potential (MMP) in cancer cell lines and patient-derived tumor cells (PDCs).
Jin Won Park, Sun-Pyo Hong, Jin Hee Lee, Seung Hwan Moon, Young Seok Cho, Kyung-Ho Jung, Jeeyun Lee, Kyung-Han Lee   +7 more
doaj   +1 more source

Assessment of Thyroid Uptake Ratio Values in a Normal Population. Establishment of Normal Reference Values for 99mTc‐Pertechnetate Thyroid Uptake in an Australian Population

Journal of Medical Radiation Sciences, EarlyView.
An Australian first, this study examined normal reference ranges for 99mTc‐pertechnetate thyroid uptake. Through a retrospective and prospective analysis, this study found a new reference range of 0.4%–2.4%. The findings suggest that locally derived reference values may differ from historical data and highlight the importance of region‐specific ...
Bethany Wornes, Amalia Karahalios, Melanie Tempest   +2 more
wiley   +1 more source

Radiopharmaceuticals for Targeted Tumor Diagnosis and Therapy

CHIMIA, 2000
Radiopharmaceutical research and development is carried out by the Center for Radiopharmaceutical Science as part of the PSI Life Science Department, the Department of Applied BioSciences at the Swiss Federal Institute of Technology Zürich and ...
Robert Waibel, Matthias Brühlmeier, Alain Blanc, Olga Gasser, Raimo Pellikka, Kurt Zimmermann, Rolf Schwarzbach, Elisa Garcia-Garayoa, Peter Bläuenstein, Roger Schibli, Ilse Novak-Hofer, P. August Schubiger   +11 more
doaj  

Preparation and Biodistribution of 99mTc-Pamidronate as Bone Imaging Agent

Journal of Isotopes, 2016
Labeling of Pamidronate (PAM) with 99mTc was studied by a direct labeling method in the presence of SnCl2•2H2O as reducing agent. The influences of the concentration of SnCl2•2H2O, PAM concentration and pH value, reaction time on labeling yield were ...
LUO Hong-yi, SHEN Lang-Tao, LIANG Ji-xin, YANG Chun-hui   +3 more
doaj   +1 more source

FDG PET/CT in the detection of infections and inflammations [PDF]

Archive of Oncology, 2012
Detection of inflammation/infection still remains great clinical problem. That is why nuclear medicine procedures still play a significant role regarding this issue.
Artiko Vera
doaj   +1 more source