Results 181 to 190 of about 3,121 (209)

Decoding SR protein regulation: kinases, phosphatases, and therapeutic targeting strategies. [PDF]

open access: yesCell Oncol (Dordr)
Liu N   +3 more
europepmc   +1 more source

A Kinase Anchoring Protein (AKAP) Interaction and Dimerization of the RIα and RIβ Regulatory Subunits of Protein Kinase A In vivo by the Yeast Two Hybrid System

open access: closedJournal of Molecular Biology, 2003
Protein kinase A (PKA) regulatory (R) subunits dimerize through an N-terminal motif. Such dimerization is necessary for binding to PKA anchoring proteins (AKAPs) and targeting of PKA to its site of action. In the present study, we used the yeast two-hybrid system as an in vivo bio-reporter assay and analyzed the formation of homo- and heterodimeric ...
Cathrine R Carlson, Kjetil Taskén
exaly   +4 more sources

A-Kinase Anchoring Proteins (AKAPs)

open access: closed, 2021
Ryan Walker‐Gray, Enno Klußmann
openalex   +2 more sources
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Analysis of A-kinase anchoring protein (AKAP) interaction with protein kinase A (PKA) regulatory subunits: PKA isoform specificity in AKAP binding

Journal of Molecular Biology, 2000
Compartmentalization of cAMP-dependent protein kinase (PKA) is in part mediated by specialized protein motifs in the dimerization domain of the regulatory (R)-subunits of PKA that participate in protein-protein interactions with an amphipathic helix region in A-kinase anchoring proteins (AKAPs).
Friedrich W Herberg, Kjetil Taskén
exaly   +3 more sources

A-Kinase Anchoring Protein (AKAP)

2016
Paula J Bucko   +2 more
exaly   +2 more sources

ANALYSIS OF A NOVEL A-KINASE ANCHORING PROTEIN 100, (AKAP 100)

open access: closedBiochemical Society Transactions, 1995
Considerable research has focused on determining the role of cAMP in intracellular signal transduction, (I). Krebs and colleagues in 1968 (2) made a key discovery, which ultimately linked the action of CAMP to the then novel cAMPdependent protein kinase, which through phosphotylation of target substrates potentiates the hormonal response by subtly ...
Shirley McCartney   +2 more
openalex   +3 more sources

Distribution of regulatory subunits of protein kinase A and A kinase anchor proteins (AKAP 95, 150) in rat pinealocytes

Cell and Tissue Research, 2002
The rat pineal organ is an established model to study signal transduction cascades that are activated by norepinephrine (NE) and cause increases in cAMP levels and stimulation of protein kinase A (PKA). PKA type II catalyzes the phosphorylation of the transcription factor cAMP-response-element-binding protein (CREB) which is essential for the ...
Koch, Marco, Korf, H.-W.
openaire   +3 more sources

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