Results 181 to 190 of about 3,121 (209)
Centrosomal actin pool levels regulated by localized PKA set the threshold for T cell polarization. [PDF]
Simao M, Régnier F, Randriamampita C.
europepmc +1 more source
Decoding SR protein regulation: kinases, phosphatases, and therapeutic targeting strategies. [PDF]
Liu N +3 more
europepmc +1 more source
Targeting mitochondria to protect the heart: a matter of balance? [PDF]
Zouein FA, Booz GW.
europepmc +1 more source
A-kinase anchoring protein-mediated compartmentalization of pro-survival signaling in the retina. [PDF]
Mackiewicz J, Boczek T.
europepmc +1 more source
Protein kinase A (PKA) regulatory (R) subunits dimerize through an N-terminal motif. Such dimerization is necessary for binding to PKA anchoring proteins (AKAPs) and targeting of PKA to its site of action. In the present study, we used the yeast two-hybrid system as an in vivo bio-reporter assay and analyzed the formation of homo- and heterodimeric ...
Cathrine R Carlson, Kjetil Taskén
exaly +4 more sources
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Journal of Molecular Biology, 2000
Compartmentalization of cAMP-dependent protein kinase (PKA) is in part mediated by specialized protein motifs in the dimerization domain of the regulatory (R)-subunits of PKA that participate in protein-protein interactions with an amphipathic helix region in A-kinase anchoring proteins (AKAPs).
Friedrich W Herberg, Kjetil Taskén
exaly +3 more sources
Compartmentalization of cAMP-dependent protein kinase (PKA) is in part mediated by specialized protein motifs in the dimerization domain of the regulatory (R)-subunits of PKA that participate in protein-protein interactions with an amphipathic helix region in A-kinase anchoring proteins (AKAPs).
Friedrich W Herberg, Kjetil Taskén
exaly +3 more sources
ANALYSIS OF A NOVEL A-KINASE ANCHORING PROTEIN 100, (AKAP 100)
Considerable research has focused on determining the role of cAMP in intracellular signal transduction, (I). Krebs and colleagues in 1968 (2) made a key discovery, which ultimately linked the action of CAMP to the then novel cAMPdependent protein kinase, which through phosphotylation of target substrates potentiates the hormonal response by subtly ...
Shirley McCartney +2 more
openalex +3 more sources
Cell and Tissue Research, 2002
The rat pineal organ is an established model to study signal transduction cascades that are activated by norepinephrine (NE) and cause increases in cAMP levels and stimulation of protein kinase A (PKA). PKA type II catalyzes the phosphorylation of the transcription factor cAMP-response-element-binding protein (CREB) which is essential for the ...
Koch, Marco, Korf, H.-W.
openaire +3 more sources
The rat pineal organ is an established model to study signal transduction cascades that are activated by norepinephrine (NE) and cause increases in cAMP levels and stimulation of protein kinase A (PKA). PKA type II catalyzes the phosphorylation of the transcription factor cAMP-response-element-binding protein (CREB) which is essential for the ...
Koch, Marco, Korf, H.-W.
openaire +3 more sources

