Results 131 to 140 of about 115,019,931 (299)

Chromatin Packing Domain Engineering Through the Manipulation of Nuclear Cationic States

Advanced Science, EarlyView.
Manipulation of intranuclear divalent cation concentrations rapidly and reversibly remodels chromatin packing domains in living cells. Magnesium depletion disrupts domain compaction, heterochromatin organization, and transcriptional regulation, whereas magnesium loading promotes more compact and stable domains.
Cody L. Dunton, Carrillo Paola Gonzalez, Luay Almassalha, Wing Shun Li, Ruyi Gong, Nicolas Acosta, I Chae Ye, Jane Frederick, Christopher Hogg, Saira John, J. A. Gareth Williams, Rikkert J. Nap, Igal Szleifer, Vadim Backman   +13 more
wiley   +1 more source

The role of cGMP signalling in regulating life cycle progression of Plasmodium. [PDF]

, 2012
The 3'-5'-cyclic guanosine monophosphate (cGMP)-dependent protein kinase (PKG) is the main mediator of cGMP signalling in the malaria parasite. This article reviews the role of PKG in Plasmodium falciparum during gametogenesis and blood stage schizont ...
Baker, David A, Bowyer, Paul W, Hopp, Christine S   +2 more
core   +1 more source

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source

IQ Motif Containing GTPase Activating Proteins (IQGAPs), A-Kinase Anchoring Proteins (AKAPs) and Kinase Suppressor of Ras Proteins (KSRs) in Scaffolding Oncogenic Pathways and Their Therapeutic Potential. [PDF]

ACS Omega, 2022
Mohapatra T, Dixit M.
europepmc   +1 more source

How anchoring proteins shape pain

, 2014
Cellular responsiveness to external stimuli can be altered by extracellular mediators which activate membrane receptors, in turn signalling to the intracellular space via calcium, cyclic nucleotides, membrane lipids or enzyme activity.
Fischer, Michael J. M., McNaughton, Peter A.; id_orcid   +1 more
core   +1 more source

Human TPX2 is required for targeting Aurora-A kinase to the spindle [PDF]

, 2002
Aurora-A is a serine-threonine kinase implicated in the assembly and maintenance of the mitotic spindle. Here we show that human Aurora-A binds to TPX2, a prominent component of the spindle apparatus.
Roman Körner, Erich A. Nigg, Oliver J. Gruss, Silljé, Herman H. W., Gruss, O. J., Kufer, T. A., Körner, R., Nigg, E. A., Meraldi, P., Sillje, H. H. W., Thomas A. Kufer, Kufer, Thomas A., Gruss, Oliver J., Nigg, Erich A., Koerner, R., Patrick Meraldi, Körner, Roman, Meraldi, Patrick, Herman H.W. Silljé   +18 more
core   +1 more source

A Personalized Haplotype‐Resolved Near‐Gapless Genome Framework for Somatic Variant Discovery in Hepatocellular Carcinoma

Advanced Science, EarlyView.
A patient‐specific, haplotype‐resolved genome framework improves detection and interpretation of somatic variants in hepatocellular carcinoma. Using multi‐platform sequencing, the personalized assembly resolves complex regions including centromeres and MHC/HLA loci, enhances structural variant discovery, and links regulatory alterations to allele ...
Jiazheng Lin, Yao Xiao, Shuangzi Luo, Yifan Li, Wenfei Zhang, Xiaoyu Zhang, Xinyi Wang, Di Wu, Jieru Hong, Yongkun Luan, Xun Huang, Yixiu Wang, Ningbo Wu, Xiaoxiao Hu, Fei Zhao, Wei Li, Xiao Luo, Bi Shi   +17 more
wiley   +1 more source

Myomegalin is a novel A-kinase anchoring protein involved in the phosphorylation of cardiac myosin binding protein C

BMC Cell Biology, 2011
Background Cardiac contractility is regulated by dynamic phosphorylation of sarcomeric proteins by kinases such as cAMP-activated protein kinase A (PKA).
Riedemann Johann, Mouton Jomien, Korkie Lundi J, Kinnear Craig J, Loos Benjamin, Ramburan Amsha, Uys Gerrida M, Moolman-Smook Johanna C   +7 more
doaj   +1 more source

Selectivity and Regulation of A-kinase Anchoring Proteins in the Heart

Journal of Biological Chemistry, 2000
Downstream regulation of the cAMP-dependent protein kinase (PKA) pathway is mediated by anchoring proteins (AKAPs) that sequester PKA to specific subcellular locations through binding to PKA regulatory subunits (RI or RII).
Daniel R. Zakhary, M. Fink, M. L. Ruehr, M. Bond   +3 more
semanticscholar   +1 more source

Arabidopsis STN7 Kinase Provides a Link between Short- and Long-Term Photosynthetic Acclimation [PDF]

, 2009
Flowering plants control energy allocation to their photosystems in response to light quality changes. This includes the phosphorylation and migration of light-harvesting complex II (LHCII) proteins (state transitions or short-term response) as well as ...
Leister, Dario, A. Ihnatowicz, M. Scharfenberg, R. Wagner, Ihnatowicz, Anna, A. Schneider, Pesaresi, Paolo, Pfannschmidt, Thomas, Bonardi, Vera, T. Kleine, D. Leister, Strissel, Henning, Schneider, Anja, V. Bonardi, M. Pribil, Wagner, Raik, A. Hertle, Kleine, Tatjana, H. Strissel, P. Pesaresi, Scharfenberg, Michael, T. Pfannschmidt, Pribil, Mathias, Hertle, Alexander   +23 more
core   +1 more source