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Protein S-Nitrosylation in Heart Failure: A Compartment-Resolved Review of Mechanisms, Evidence Boundaries, and Translational Perspectives. [PDF]
Antioxidants (Basel)Shi M, Li Y, Zhu Z, Xie Y, Zhang X.
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The role of A-kinase anchoring proteins in cancer development
Cellular Signalling, 2017Cancer development is a multifactorial process resulting from the aberrant activation of multiple signaling pathways. It has become increasingly clear that the coordination of the signaling events leading to cancer formation and progression is under the control of macromolecular transduction complexes organized by scaffolding proteins.
Dario Diviani
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Modulation of cardiac function by A-kinase anchoring proteins.
Current Opinion in Pharmacology, 2008 The cAMP-dependent kinase (PKA) is a broad specificity kinase that controls several fundamental processes in the heart including the strength and the frequency of contraction, the duration of the cardiac action potential as well as the activation of signaling pathways associated with the onset of cardiac hypertrophy and heart failure.
D. Diviani
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Regulation of G Protein-Coupled Receptor Signaling by A-Kinase Anchoring Proteins
Journal of Receptor and Signal Transduction Research, 2006 Specificity of transduction events is controlled at the molecular level by scaffold, anchoring, and adaptor proteins, which position signaling enzymes at proper subcellular localization.
Dario Diviani
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A-kinase anchoring proteins: protein kinase A and beyond.
Current Opinion in Cell Biology, 2000Compartmentalization of kinases and phosphatases is a key determinant in the specificity of second messenger mediated signaling events. Localization of the cAMP-dependent protein kinase (PKA) and other signaling enzymes is mediated by interaction with A-kinase anchoring proteins (AKAPs).
A. S. Edwards, J. D. Scott
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A-kinase-anchoring proteins and cytoskeletal signalling events.
Biochemical Society Transactions, 2001Targeting of protein kinases and phosphatases to the cytoskeleton enhances the regulation of many signalling events. Cytoskeletal signalling complexes facilitate this process by optimizing the relay of messages from membrane receptors to specific sites on the actin cytoskeleton.
J. D. Scott
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A-kinase anchoring proteins as the basis for cAMP signaling.
Handbook of Experimental Pharmacology, 2008Common challenges to any cell are the processing of the extracellular stimuli it receives into intracellular signaling cascades that initiate a multitude of diverse biological functions. However, many of these stimuli act via a common signaling pathway, suggesting the cell must somehow discriminate between different stimuli and respond accordingly ...
Kimberly L. Dodge-Kafka +2 more
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Regulation of ion channels by cAMP-dependent protein kinase and A-kinase anchoring proteins
Current Opinion in Neurobiology, 1998William A. Catterall +2 more
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Role of A-kinase anchoring proteins in cyclic-AMP-mediated Schwann cell proliferation.
Cellular Signalling, 2021Proliferation of Schwann cells during peripheral nerve development is stimulated by the heregulin/neuregulin family of growth factors expressed by neurons.
A. Asirvatham +4 more
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