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A-Kinase Anchoring Proteins (AKAPs)
Encyclopedia of Molecular Pharmacology, 2020R. Walker-Gray, E. Klussmann
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The macromolecular state of A‐kinase anchoring protein
Journal of Molecular Recognition, 2011The amendment of the interpretation of recently published size‐exclusion chromatography (SEC) data for A‐kinase anchoring protein (AKAP12) on Sephacryl‐S400 has led to an increase in the estimated size of the supermolecular state from 840 to at least 6000 kDa.
Patel, Trushar R., Winzor, Donald J.
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A-kinase anchoring protein targeting of protein kinase A in the heart
Journal of Molecular and Cellular Cardiology, 2004There is increasing evidence that subcellular targeting of signaling molecules is an important means of regulating the protein kinase A (PKA) pathway. Subcellular organization of the signaling molecules in the PKA pathway insures that a signal initiated at the receptor level is transferred efficiently to a PKA substrate eliciting some cellular response.
Mary L, Ruehr +2 more
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The biological functions of A-kinase anchor proteins.
Journal of molecular biology, 2001cAMP-dependent protein kinase is targeted to discrete subcellular locations by a family of specific anchor proteins (A-kinase anchor proteins, AKAPs). Localization recruits protein kinase A (PKA) holoenzyme close to its substrate/effector proteins, directing and amplifying the biological effects of cAMP signaling.AKAPs include two conserved structural ...
FELICIELLO, ANTONIO +2 more
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Mechanisms of Protein Kinase A Anchoring
2010The second messenger cyclic adenosine monophosphate (cAMP), which is produced by adenylyl cyclases following stimulation of G-protein-coupled receptors, exerts its effect mainly through the cAMP-dependent serine/threonine protein kinase A (PKA). Due to the ubiquitous nature of the cAMP/PKA system, PKA signaling pathways underlie strict spatial and ...
Philipp, Skroblin +4 more
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British Journal of Pharmacology, 2014
The universal second messenger cAMP is generated upon stimulation of G(s) protein-coupled receptors, such as the (2)-adreneoceptor, and leads to the activation of PKA, the major cAMP effector protein. PKA oscillates between an on and off state and thereby regulates a plethora of distinct biological responses. The broad activation pattern of PKA and its
Poppinga, W. J. +3 more
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The universal second messenger cAMP is generated upon stimulation of G(s) protein-coupled receptors, such as the (2)-adreneoceptor, and leads to the activation of PKA, the major cAMP effector protein. PKA oscillates between an on and off state and thereby regulates a plethora of distinct biological responses. The broad activation pattern of PKA and its
Poppinga, W. J. +3 more
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Functional Anchoring of the cAMP-Dependent Protein Kinase
Trends in Cardiovascular Medicine, 1998The precision of cAMP-responsive events is controlled in part through compartmentalization of the signal transduction machinery. Recent evidence suggests that the cAMP-dependent protein kinase (PKA) is localized to specific subcellular compartments through association with A Kinase Anchoring Proteins (AKAPs).
B J, Murphy, J D, Scott
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A-kinase anchor proteins in endocrine systems and reproduction
Trends in Endocrinology & Metabolism, 2001Over the past few years, significant progress has been made in characterizing the expression and localization of proteins that act as scaffolds for cAMP-dependent protein kinase (PK-A). These A-kinase anchor proteins (AKAPs) tether PK-A to intracellular organelles and structures, sequestering the kinase near its physiological substrates.
S B, Moss, G L, Gerton
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Properties of A-kinase anchoring proteins
Biochemical Society Transactions, 1996Z E, Hausken, J D, Scott
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