Results 91 to 100 of about 8,093,612 (203)

Advances in CRISPR Base Editing: From Molecular Evolution to Therapeutic Applications in Genomic Medicine

open access: yesJournal of Cellular and Molecular Medicine, Volume 30, Issue 8, April 2026.
ABSTRACT CRISPR‐Cas9 systems revolutionized gene editing, but inherent drawbacks, namely DNA double‐strand breaks (DSBs) and the difficulty of achieving precise repairs (due to low HDR efficiency), led researchers to invent new, more accurate gene editing tools.
Melike Aliciaslan   +3 more
wiley   +1 more source

Assessment of Apple Blotch (Diplocarpon coronariae) Symptom Progression on Malus × domestica Leaves

open access: yesPlant Breeding, Volume 145, Issue 2, Page 326-338, April 2026.
ABSTRACT Apple blotch is a fungal disease of increasing importance in European apple cultivation. Infection by Diplocarpon coronariae leads to premature leaf abscission in summer, weakening tree vigour and exacerbating harvest losses. Developing resistant cultivars represents a promising preventive strategy.
Sophie Richter   +5 more
wiley   +1 more source

Spartan Daily, April 3, 1951 [PDF]

open access: yes, 1951
Volume 39, Issue 111https://scholarworks.sjsu.edu/spartandaily/11532/thumbnail ...
San Jose State University, School of Journalism and Mass Communications
core   +1 more source

Increasing the {\nu} = 5 / 2 gap energy: an analysis of MBE growth parameters

open access: yes, 2014
The fractional quantized Hall state (FQHS) at the filling factor {\nu} = 5/2 is of special interest due to its possible application for quantum computing.
Baer, Stephan   +7 more
core   +1 more source

Cholesterol efflux responds to viral load and CD4 counts in HIV+ patients and is dampened in HIV exposed

open access: yesJournal of Lipid Research, 2018
Cholesterol efflux (CE) capacity has been inversely associated with atherosclerosis and may provide an insight on inflammation occurring in human immunodeficiency virus (HIV) individuals. We address this by studying CE in HIV patients at different stages
Olivia Tort   +9 more
doaj   +1 more source

Comprehensive Profiling of N6‐methyladnosine (m6A) Readouts Reveals Novel m6A Readers That Regulate Human Embryonic Stem Cell Differentiation

open access: yesAdvanced Science, Volume 13, Issue 18, 27 March 2026.
This research deciphers the m6A transcriptome by profiling its sites and functional readout effects: from mRNA stability, translation to alternative splicing, across five different cell types. Machine learning model identifies novel m6A‐binding proteins DDX6 and FXR2 and novel m6A reader proteins FUBP3 and L1TD1.
Zhou Huang   +11 more
wiley   +1 more source

Multi‐Tissue Genetic Regulation of RNA Editing in Pigs

open access: yesAdvanced Science, Volume 13, Issue 17, 23 March 2026.
This study presents the first multi‐tissue map of RNA editing and its genetic regulation in pigs. By integrating RNA editing profiles, edQTL mapping, GWAS, and cross‐species comparisons, this work establishes RNA editing as a distinct regulatory layer linking genetic variation to complex traits, highlighting its functional and evolutionary significance.
Xiangchun Pan   +21 more
wiley   +1 more source

The Cowl - v.21 - n.10 - Jan 14, 1959 [PDF]

open access: yes, 1959
The Cowl - student newspaper of Providence College. Volume 21, Number 10 - January 14, 1959.

core   +1 more source

RNA‐Based Therapies for Inherited Metabolic Disorders

open access: yesJournal of Inherited Metabolic Disease, Volume 49, Issue 2, March 2026.
ABSTRACT Inherited metabolic disorders (IMDs) are a diverse and complex group of genetic conditions resulting from deficiencies in enzymes, transporters, or cofactors. These deficiencies lead to metabolic dysfunction and severe clinical consequences. Despite significant progress in understanding their molecular basis, treatment options remain limited ...
Reddy Sreekanth Vootukuri   +5 more
wiley   +1 more source

A‐to‐I editing on tRNAs: Biochemical, biological and evolutionary implications

open access: yesFEBS Letters, 2014
Inosine on transfer RNAs (tRNAs) are post‐transcriptionally formed by a deamination mechanism of adenosines at positions 34, 37 and 57 of certain tRNAs. Despite its ubiquitous nature, the biological role of inosine in tRNAs remains poorly understood.
Torres, Adrian Gabriel   +5 more
openaire   +2 more sources

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