Results 231 to 240 of about 1,508,590 (281)

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

RETRACTION: The PI3K/mTOR Dual Inhibitor NVP‐BEZ235 Stimulates Mutant p53 Degradation to Exert Anti‐Tumor Effects on Triple‐Negative Breast Cancer Cells

FEBS Open Bio, EarlyView.
RETRACTION: J. Cai, J. Xia, J. Zou, Q. Wang, Q. Ma, R. Sun, H. Liao, L. Xu, D. Wang, and X. Guo, “The PI3K/mTOR Dual Inhibitor NVP‐BEZ235 Stimulates Mutant p53 Degradation to Exert Anti‐Tumor Effects on Triple‐Negative Breast Cancer Cells,” FEBS Open Bio 10, no. 4 (2020): 535–545, https://doi.org/10.1002/2211‐5463.12806.
wiley   +1 more source

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RNA A-to-I editing, environmental exposure, and human diseases

Critical Reviews in Toxicology, 2021
Epigenetic modifications have gained attention since they can be potentially changed with environmental stimuli and can be associated with adverse health outcomes.
A. Çayır
semanticscholar   +4 more sources

Site‐selective versus promiscuous A‐to‐I editing

WIREs RNA, 2011
AbstractRNA editing by adenosine deamination is acting on polymerase II derived transcripts in all metazoans. Adenosine‐to‐inosine (A‐to‐I) editing is mediated by the adenosine deaminase that acts on RNA (ADAR) enzymes. Two types of adenosine to inosine (A‐to‐I) RNA editing have been defined: site selective and hyper‐editing.
Helene Wahlstedt, Marie f#x2013;hman
semanticscholar   +3 more sources

A-to-I editing of microRNAs: regulating the regulators?

Seminars in Cell & Developmental Biology, 2012
An important epigenetic mechanism in mammals is adenosine deamination, which generates transcriptome variety through the conversion of single adenosines into inosines in RNA molecules. Inosine is interpreted as guanosine by the translational machinery, and when A-to-I RNA editing occurs in the coding region of pre-mRNA molecules this substitution can ...
W. M. Gommans
semanticscholar   +3 more sources

Nanopore sequencing to detect A-to-I editing sites.

Methods in Enzymology
Adenosine-to-inosine (A-to-I) RNA editing, mediated by the ADAR family of enzymes, is pervasive in metazoans and functions as an important mechanism to diversify the proteome and control gene expression. Over the years, there have been multiple efforts to comprehensively map the editing landscape in different organisms and in different disease states ...
Jia Wei Joel Heng, Meng How Tan
semanticscholar   +3 more sources

Evolutionary driving forces of A‐to‐I editing in metazoans

Wiley Interdisciplinary Reviews - RNA, 2021
Adenosine‐to‐inosine (A‐to‐I) RNA editing is an evolutionarily conserved mechanism that converts adenosines to inosines in metazoans' transcriptomes. However, the landscapes of editomes have considerably changed during evolution.
Y. Duan, Xiaolu Tang, Jian Lu
semanticscholar   +1 more source