Results 241 to 250 of about 1,508,590 (281)

Genome-Wide Analysis of A-to-I RNA Editing.

Methods in molecular biology, 2016
Adenosine (A)-to-inosine (I) RNA editing is a fundamental posttranscriptional modification that ensures the deamination of A-to-I in double-stranded (ds) RNA molecules. Intriguingly, the A-to-I RNA editing system is particularly active in the nervous system of higher eukaryotes, altering a plethora of noncoding and coding sequences.
Yiannis A. Savva, G. Laurent, R. Reenan
semanticscholar   +3 more sources

A-to-I RNA Editing is Induced Upon Hypoxia

Shock, 2011
Regulating gene expression is part of a cell's response to hypoxia. A-to-I RNA editing is an epigenetic phenomenon that can contribute to RNA and protein levels and to isoform diversity. In this study, we identified alterations in the levels of RNA editing following hypoxic stress in three genes: MED13, STAT3, and F11R.
Yael, Nevo-Caspi, Ninette, Amariglio, Gideon, Rechavi, Gideon, Paret   +3 more
openaire   +2 more sources

Detection of A-to-I Hyper-edited RNA Sequences

2020
Following A-to-I editing of double-stranded RNA (dsRNA) molecules, sequencing reactions interpret the edited inosine (I) as guanosine (G). For this reason, current methods to detect A-to-I editing sites work to align RNA sequences to their reference DNA sequence in order to reveal A-to-G mismatches.
Roni, Cohen-Fultheim, Erez Y, Levanon
openaire   +2 more sources

Editing the message from A to I

Nature Biotechnology, 2004
Numerous adenosine-to-inosine editing sites found in mRNA sequences raise new questions about the biological significance of RNA editing.
openaire   +1 more source

A-to-I editing of protein coding and noncoding RNAs

Critical Reviews in Biochemistry and Molecular Biology, 2012
Adenosine deaminase acting on RNA (ADAR) catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) substrates. Inosine pairs preferentially with cytidine, as opposed to uridine; therefore, ADAR editing alters the sequence and base pairing properties of both protein-coding and non-coding RNA.
Arka, Mallela, Kazuko, Nishikura
openaire   +2 more sources

Abundant A-to-I editing in the human transcriptome.

Drug Discovery Today, 2004
Nicole Johnston
semanticscholar   +2 more sources

A-to-I RNA editing — immune protector and transcriptome diversifier

Nature Reviews Genetics, 2018
Modifications of RNA affect its function and stability. RNA editing is unique among these modifications because it not only alters the cellular fate of RNA molecules but also alters their sequence relative to the genome. The most common type of RNA editing is A-to-I editing by double-stranded RNA-specific adenosine deaminase (ADAR) enzymes.
Eli Eisenberg, Erez Y Levanon
exaly   +4 more sources

A-to-I RNA Editing in Human Cells

2021
A thesis presented to the faculty of The Rockefeller University in partial fulfillment of the requirements for the degree of Doctor of ...
openaire   +1 more source

Aptazyme-directed A-to-I RNA editing

As a promising therapeutic approach, the RNA editing process can correct pathogenic mutations and is reversible and tunable, without permanently altering the genome. RNA editing mediated by human ADAR proteins offers unique advantages, including high specificity and low immunogenicity.
Xilei, Ai, Zhuo, Tang
openaire   +2 more sources

A-to-I and C-to-U editing within transfer RNAs

Biochemistry (Moscow), 2011
A significant number of post-transcriptional changes occur during the generation of mature transfer RNAs (tRNAs). These changes within precursor-tRNA molecules include the processing of 5' and 3' termini, the introduction of modifications, and also RNA editing. In this review, we will detail the reported cases of A-to-I and C-to-U tRNA editing.
Su, A., Randau, L.
openaire   +3 more sources