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A-to-I RNA editing: The “ADAR” side of human cancer
Seminars in Cell & Developmental Biology, 2012Carcinogenesis is a complex, multi-stage process depending on both endogenous and exogenous factors. In the past years, DNA mutations provided important clues to the comprehension of the molecular pathways involved in numerous cancers. Recently, post-transcriptional modification events, such as RNA editing, are emerging as new players in several human ...
Galeano, Federica +3 more
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Bioinformatic Approaches for Identification of A-to-I Editing Sites
2011The first discoveries of mammalian A-to-I RNA editing have been serendipitous. In conjunction with the fast advancement in sequencing technology, systematic methods for prediction and detection of editing sites have been developed, leading to the discovery of thousands of A-to-I editing sites.
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A-to-I editing prevents self-RNA sensing
Nature Reviews Molecular Cell Biology, 2022openaire +2 more sources
Perturbing A-to-I RNA Editing Using Genetics and Homologous Recombination
2011Evidence for the chemical conversion of adenosine-to-inosine (A-to-I) in messenger RNA (mRNA) has been detected in numerous metazoans, especially those "most successful" phyla: Arthropoda, Mollusca, and Chordata. The requisite enzymes for A-to-I editing, ADARs (adenosine deaminases acting on RNA) are highly conserved and are present in every higher ...
Cynthia J, Staber +3 more
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ALU A-to-I RNA Editing: Millions of Sites and Many Open Questions.
Methods in molecular biology, 2021Amos A Schaffer, E. Levanon
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Structural biology of CRISPR–Cas immunity and genome editing enzymes
Nature Reviews Microbiology, 2022Joy Y Wang +2 more
exaly
Z-Form Stabilization By The Zα Domain Of Adar1p150 Has Subtle Effects On A-To-I Editing
bioRxivParker J. Nichols +8 more
semanticscholar +1 more source