Results 101 to 110 of about 574,299 (199)

Regulatory factors governing adenosine-to-inosine (A-to-I) RNA editing [PDF]

Bioscience Reports, 2015
Adenosine-to-inosine (A-to-I) RNA editing, the most prevalent mode of transcript modification in higher eukaryotes, is catalysed by the adenosine deaminases acting on RNA (ADARs). A-to-I editing imposes an additional layer of gene regulation as it dictates various aspects of RNA metabolism, including RNA folding, processing, localization and ...
Hong, HuiQi, Lin, Jaymiesiqi, Leilei
openaire   +2 more sources

Multimodal CRISPR screens uncover DDX39B as a global repressor of A-to-I RNA editing

Cell Reports
Summary: Adenosine-to-inosine (A-to-I) RNA editing is a critical post-transcriptional modification that diversifies the transcriptome and influences various cellular processes, yet its regulatory mechanisms remain largely unknown.
Tianzi Wei, Jiaxuan Li, Xiang Lei, Risheng Lin, Qingyan Wu, Zhenfeng Zhang, Shimin Shuai, Ruilin Tian   +7 more
doaj   +1 more source

Reduction of RNA A-to-I editing in Drosophila acclimated to heat shock

Kaohsiung Journal of Medical Sciences, 2013
Although an increasing number of RNA adenosine-to-inosine (A-to-I) editing sites are being discovered, how the editing frequencies of these sites are modulated to fine-tune protein function in adaptive responses is not well understood.
Joel Stocker, Hurng-Wern Huang, Hong-Ming Wang, Hsueh-Wei Chang, Chien-Chih Chiu, Chung-Lung Cho, Chao-Neng Tseng   +6 more
doaj   +1 more source

RAGs and Regulation of Autoantibodies [PDF]

, 2004
Autoreactive antibodies are etiologic agents in a number of autoimmune diseases. Like all other antibodies these antibodies are produced in developing B cells by V(D)J recombination in the bone marrow.
Casellas, Rafael, Jankovic, Mila, Nussenzweig, Michel C., Wardemann, ­Hedda, Yannoutsos, Nikos   +4 more
core   +1 more source

Detecting haplotype-specific transcript variation in long reads with FLAIR2

Genome Biology
Background RNA-seq has brought forth significant discoveries regarding aberrations in RNA processing, implicating these RNA variants in a variety of diseases.
Alison D. Tang, Colette Felton, Eva Hrabeta-Robinson, Roger Volden, Christopher Vollmers, Angela N. Brooks   +5 more
doaj   +1 more source

Uncovering RNA editing sites in long non-coding RNAs

Frontiers in Bioengineering and Biotechnology, 2014
RNA editing is an important co/post-transcriptional molecular process able to modify RNAs by nucleotide insertions/deletions or substitutions. In human, the most common RNA editing event involves the deamination of adenosine (A) into inosine (I) through ...
Ernesto ePicardi, Ernesto ePicardi, Anna Maria D'Erchia, Anna Maria D'Erchia, Angela eGallo, Antonio eMontalvo, Antonio eMontalvo, Graziano ePesole, Graziano ePesole   +8 more
doaj   +1 more source

Genome editing technologies to fight infectious diseases [PDF]

, 2017
Genome editing by programmable nucleases represents a promising tool that could be exploited to develop new therapeutic strategies to fight infectious diseases.
Barzon, Luisa, Pal\ue3\ub9, Giorgio, Trevisan, Marta   +2 more
core   +1 more source

CAS9 is a genome mutator by directly disrupting DNA-PK dependent DNA repair pathway. [PDF]

, 2020
With its high efficiency for site-specific genome editing and easy manipulation, the clustered regularly interspaced short palindromic repeats (CRISPR)/ CRISPR associated protein 9 (CAS9) system has become the most widely used gene editing technology in ...
Chen, Qu, Fu, Xuemei, Kim, Jinchul, Liu, Jingfeng, Tang, Qingshuang, Xu, Shuxiang, Xu, Yang   +6 more
core  

Genome editing in potato via CRISPR-Cas9 ribonucleoprotein delivery [PDF]

, 2018
Clustered regularly interspaced short palindromic repeats and CRISPR-associated protein-9 (CRISPR-Cas9) can be used as an efficient tool for genome editing in potato (Solanum tuberosum).
Andersson, Andersson, Cho, Clasen, Eriksson, Gorbunova, Hartung, Jinek, Jones, Kim, Kuipers, Kuipers, Larkin, Liang, Muthoni, Nelson, Sawai, Shepard, Svitashev, Visser, Woo, Xu, Zhang   +22 more
core   +1 more source

Practical guidance for the implementation of the CRISPR genome editing tool in filamentous fungi [PDF]

, 2019
Background: Within the last years, numerous reports described successful application of the CRISPR nucleases Cas9 and Cpf1 for genome editing in filamentous fungi.
Haefner, Stefan, Kwon, Jin, Meyer, Vera, Schütze, Tabea, Spohner, Sebastian   +4 more
core   +1 more source