Results 111 to 120 of about 134,460,322 (302)
Uncovering RNA editing sites in long non-coding RNAs
Frontiers in Bioengineering and Biotechnology, 2014 RNA editing is an important co/post-transcriptional molecular process able to modify RNAs by nucleotide insertions/deletions or substitutions. In human, the most common RNA editing event involves the deamination of adenosine (A) into inosine (I) through ...
Ernesto ePicardi +8 more
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
RNA A-to-I editing, environmental exposure, and human diseases
, 2021 Epigenetic modifications have gained attention since they can be potentially changed with environmental stimuli and can be associated with adverse health outcomes.
Akin Cayir (4234483)
core +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
A-to-I RNA editing in hematologic immunity and malignancy
Experimental HematologyBlood cells exhibit a profound relationship with RNA editing, particularly adenosine deaminase acting on RNA 1 (ADAR1)-dependent adenosine-to-inosine (A-to-I) RNA editing, impacting immune cell activity, hematologic malignancy, and ultimately determining the efficacy of treatment options such as immune checkpoint inhibitors (ICIs).
Wei Liang Gan, Leilei Chen
openaire +2 more sources
Adaptive evolution of A-to-I auto-editing site in Adar of eusocial insects
BMC GenomicsBackground Adenosine-to-inosine (A-to-I) RNA editing is a co-/post-transcriptional modification introducing A-to-G variations in RNAs. There is extensive discussion on whether the flexibility of RNA editing exerts a proteomic diversification role, or it ...
Caiqing Zheng, Jiyao Liu, Yuange Duan
doaj +1 more source
Retinal editome profiling in mice reveals RNA editing in key developmental genes associated with retinitis pigmentosa [PDF]
PeerJBackground Adenosine-to-inosine (A-to-I) RNA editing has been found to function in various neurological disorders; however, the role of A-to-I RNA editing in retinitis pigmentosa (RP) remains unclear.
Chun-Yan Ren +6 more
doaj +2 more sources
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Population and allelic variation of A-to-I RNA editing in human transcriptomes
Genome Biology, 2017 Background A-to-I RNA editing is an important step in RNA processing in which specific adenosines in some RNA molecules are post-transcriptionally modified to inosines.
Eddie Park +6 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source