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Perturbing A-to-I RNA Editing Using Genetics and Homologous Recombination
2011Evidence for the chemical conversion of adenosine-to-inosine (A-to-I) in messenger RNA (mRNA) has been detected in numerous metazoans, especially those "most successful" phyla: Arthropoda, Mollusca, and Chordata. The requisite enzymes for A-to-I editing, ADARs (adenosine deaminases acting on RNA) are highly conserved and are present in every higher ...
Cynthia J, Staber +3 more
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Obstacles in quantifying A-to-I RNA editing by Sanger sequencing
Adenosine-to-Inosine (A-to-I) RNA editing is the most prevalent type of RNA editing, in which adenosine within a completely or largely double-stranded RNA (dsRNA) is converted to inosine by deamination. RNA editing was shown to be involved in many neurological diseases and cancer; therefore, detection of A-to-I RNA editing and quantitation of editing ...Alla, Fishman, Ayelet T, Lamm
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Structural biology of CRISPR–Cas immunity and genome editing enzymes
Nature Reviews Microbiology, 2022Joy Y Wang +2 more
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Temperature-dependent RNA editing in octopus extensively recodes the neural proteome
Cell, 2023Joshua J C Rosenthal
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RNA editing underlies genetic risk of common inflammatory diseases
Nature, 2022Qin Li, Francois Aguet, Tao Sun
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Base editing: advances and therapeutic opportunities
Nature Reviews Drug Discovery, 2020Alexis C Komor, Gene W Yeo
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RNA editing-dependent epitranscriptome diversity in cancer stem cells
Nature Reviews Cancer, 2017Qingfei Jiang, Leslie A Crews
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Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma
Nature Medicine, 2013Leilei Chen, Yangyang Song, Ming Liu
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A-to-I RNA editing in human disease
The Biomedical & Life Sciences Collection, 2013openaire +1 more source