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A-to-I and C-to-U editing within transfer RNAs
Biochemistry (Moscow), 2011A significant number of post-transcriptional changes occur during the generation of mature transfer RNAs (tRNAs). These changes within precursor-tRNA molecules include the processing of 5' and 3' termini, the introduction of modifications, and also RNA editing. In this review, we will detail the reported cases of A-to-I and C-to-U tRNA editing.
Su, A., Randau, L.
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A-to-I RNA Editing in Human Cells
2021A thesis presented to the faculty of The Rockefeller University in partial fulfillment of the requirements for the degree of Doctor of ...
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ADAR2-dependent A-to-I RNA editing in the extracellular linear and circular RNAs
Neuroscience Research, 2019Currently, no reliable biomarkers of amyotrophic lateral sclerosis (ALS) exist. In sporadic ALS, RNA editing at the glutamine/arginine site of GluA2 mRNA is specifically reduced in the motor neurons due to the downregulation of adenosine deaminase acting on RNA 2 (ADAR2).
Takashi, Hosaka +5 more
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RNA Editing inPhysarumMitochondria
2014In vitro approaches have facilitated mechanistic studies designed to look at the timing, accuracy and efficiency of insertional editing of newly synthesized RNAs. Because different assays are required for these distinct RNA populations, the two approaches are discussed separately.
Jonatha M. Gott +1 more
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Editing of Transfer RNAs in Acanthamoeba castellanii Mitochondria
Science, 1993With the discovery of RNA editing, a process whereby the primary sequence of RNA is altered after transcription, traditional concepts of genetic information transfer had to be revised. The known RNA editing systems act mainly on messenger RNAs, introducing sequence changes that alter their coding properties.
K M, Lonergan, M W, Gray
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Genome wide quantification of A-to-I RNA editing activity
, 2019Adenosine to inosine (A-to-I) RNA editing by the ADAR enzymes is a common RNA modification, preventing false activation of the innate immune system by endogenous dsRNAs. Methods for quantification of ADAR activity are sought after, due to an increasing
S. H. Roth, E. Levanon, E. Eisenberg
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RNA Editing of aDrosophilaSodium Channel Gene
Annals of the New York Academy of Sciences, 1999ABSTRACT:Extensive analysis of cDNAs from the para locus inD. melanogasterreveals posttranscriptional modifications indicative of adenosine‐to‐inosine RNA editing. Most of these edits occur in highly conserved regions of the Na+channel, and they occur in distant relatives ofD. melanogasteras well.
C J, Hanrahan +3 more
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Computational approaches for detection and quantification of A-to-I RNA-editing
Methods, 2019Adenosine deaminases that act on RNA (ADARs) catalyze adenosine-to-inosine (A-to-I) RNA editing in double-stranded RNA. Such editing is important for protection against false activation of the immune system, but also confers plasticity on the transcriptome by generating several versions of a transcript from a single genomic locus.
Yishay, Pinto, Erez Y, Levanon
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ALU A-to-I RNA Editing: Millions of Sites and Many Open Questions.
Methods in molecular biology, 2021Amos A Schaffer, E. Levanon
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Pathological RNA-protein inclusions and dysregulated A-to-I RNA editing in synucleinopathies
NeuronAggregation of RNA binding proteins and dysregulation of RNA metabolism drives pathogenesis of multiple neurodegenerative diseases. In this issue of Neuron, Belur et al.1 identified pathological NONO/SFPQ inclusions and aberrant A-to-I-edited RNAs accumulated in nucleus, leading to dysregulation of gene expression and neurodegeneration in ...
Rong, Wu, Shuying, Sun
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