Results 271 to 280 of about 590,857 (293)
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A-to-I and C-to-U editing within transfer RNAs
Biochemistry (Moscow), 2011A significant number of post-transcriptional changes occur during the generation of mature transfer RNAs (tRNAs). These changes within precursor-tRNA molecules include the processing of 5' and 3' termini, the introduction of modifications, and also RNA editing. In this review, we will detail the reported cases of A-to-I and C-to-U tRNA editing.
Su, A., Randau, L.
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Pathological RNA-protein inclusions and dysregulated A-to-I RNA editing in synucleinopathies
NeuronAggregation of RNA binding proteins and dysregulation of RNA metabolism drives pathogenesis of multiple neurodegenerative diseases. In this issue of Neuron, Belur et al.1 identified pathological NONO/SFPQ inclusions and aberrant A-to-I-edited RNAs accumulated in nucleus, leading to dysregulation of gene expression and neurodegeneration in ...
Rong, Wu, Shuying, Sun
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Perturbing A-to-I RNA Editing Using Genetics and Homologous Recombination
2011Evidence for the chemical conversion of adenosine-to-inosine (A-to-I) in messenger RNA (mRNA) has been detected in numerous metazoans, especially those "most successful" phyla: Arthropoda, Mollusca, and Chordata. The requisite enzymes for A-to-I editing, ADARs (adenosine deaminases acting on RNA) are highly conserved and are present in every higher ...
Cynthia J, Staber +3 more
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Obstacles in quantifying A-to-I RNA editing by Sanger sequencing
Adenosine-to-Inosine (A-to-I) RNA editing is the most prevalent type of RNA editing, in which adenosine within a completely or largely double-stranded RNA (dsRNA) is converted to inosine by deamination. RNA editing was shown to be involved in many neurological diseases and cancer; therefore, detection of A-to-I RNA editing and quantitation of editing ...Alla, Fishman, Ayelet T, Lamm
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Structural biology of CRISPR–Cas immunity and genome editing enzymes
Nature Reviews Microbiology, 2022Joy Y Wang +2 more
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Base editing: advances and therapeutic opportunities
Nature Reviews Drug Discovery, 2020Alexis C Komor +2 more
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Temperature-dependent RNA editing in octopus extensively recodes the neural proteome
Cell, 2023Noa Liscovitch-Brauer +2 more
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RNA editing-dependent epitranscriptome diversity in cancer stem cells
Nature Reviews Cancer, 2017Qingfei Jiang
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Base editing: precision chemistry on the genome and transcriptome of living cells
Nature Reviews Genetics, 2018Holly A Rees, David R Liu
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A-to-I RNA editing in human disease
The Biomedical & Life Sciences Collection, 2013openaire +1 more source