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Genome-Wide Analysis of A-to-I RNA Editing
2016Adenosine (A)-to-inosine (I) RNA editing is a fundamental posttranscriptional modification that ensures the deamination of A-to-I in double-stranded (ds) RNA molecules. Intriguingly, the A-to-I RNA editing system is particularly active in the nervous system of higher eukaryotes, altering a plethora of noncoding and coding sequences.
Yiannis A, Savva +2 more
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A-to-I RNA editing: The “ADAR” side of human cancer
Seminars in Cell & Developmental Biology, 2012Carcinogenesis is a complex, multi-stage process depending on both endogenous and exogenous factors. In the past years, DNA mutations provided important clues to the comprehension of the molecular pathways involved in numerous cancers. Recently, post-transcriptional modification events, such as RNA editing, are emerging as new players in several human ...
Galeano, Federica +3 more
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A-to-I and C-to-U editing within transfer RNAs
Biochemistry (Moscow), 2011A significant number of post-transcriptional changes occur during the generation of mature transfer RNAs (tRNAs). These changes within precursor-tRNA molecules include the processing of 5' and 3' termini, the introduction of modifications, and also RNA editing. In this review, we will detail the reported cases of A-to-I and C-to-U tRNA editing.
Su, A., Randau, L.
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Aptazyme-directed A-to-I RNA editing
As a promising therapeutic approach, the RNA editing process can correct pathogenic mutations and is reversible and tunable, without permanently altering the genome. RNA editing mediated by human ADAR proteins offers unique advantages, including high specificity and low immunogenicity.Xilei, Ai, Zhuo, Tang
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Identification of A-to-I RNA editing: Dotting the i’s in the human transcriptome
Biochemistry (Moscow), 2011The phenomenon of adenosine-to-inosine (A-to-I) RNA editing has attracted considerable attention from the scientific community due to its potential relationship to the evolution of cognition in animals. While A-to-I editing exists in all organisms with neurons, including those with primitive neuronal systems (hydra and nematodes), it is particularly ...
A, Kiran +3 more
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ADAR2-dependent A-to-I RNA editing in the extracellular linear and circular RNAs
Neuroscience Research, 2019Currently, no reliable biomarkers of amyotrophic lateral sclerosis (ALS) exist. In sporadic ALS, RNA editing at the glutamine/arginine site of GluA2 mRNA is specifically reduced in the motor neurons due to the downregulation of adenosine deaminase acting on RNA 2 (ADAR2).
Takashi, Hosaka +5 more
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RNA Editing inPhysarumMitochondria
2014In vitro approaches have facilitated mechanistic studies designed to look at the timing, accuracy and efficiency of insertional editing of newly synthesized RNAs. Because different assays are required for these distinct RNA populations, the two approaches are discussed separately.
Jonatha M. Gott +1 more
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A-to-I RNA Editing in Human Cells
2021A thesis presented to the faculty of The Rockefeller University in partial fulfillment of the requirements for the degree of Doctor of ...
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Editing of Transfer RNAs in Acanthamoeba castellanii Mitochondria
Science, 1993With the discovery of RNA editing, a process whereby the primary sequence of RNA is altered after transcription, traditional concepts of genetic information transfer had to be revised. The known RNA editing systems act mainly on messenger RNAs, introducing sequence changes that alter their coding properties.
K M, Lonergan, M W, Gray
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RNA Editing of aDrosophilaSodium Channel Gene
Annals of the New York Academy of Sciences, 1999ABSTRACT:Extensive analysis of cDNAs from the para locus inD. melanogasterreveals posttranscriptional modifications indicative of adenosine‐to‐inosine RNA editing. Most of these edits occur in highly conserved regions of the Na+channel, and they occur in distant relatives ofD. melanogasteras well.
C J, Hanrahan +3 more
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