Results 1 to 10 of about 3,774 (171)

Association of A1AT With Poor Functional Outcome in Patients With Acute Ischemic Stroke [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background This study aimed to investigate whether A1AT (α‐1 antitrypsin) bloodstream levels, measured acutely after ischemic stroke, can predict the outcome of patients with stroke.
Paula García‐Rodríguez, Marcel Lamana‐Vallverdú, Daisy R. Guamán‐Pilco, Anna Penalba, Laura Ramiro, Alba Simats, Júlia Faura, Alejandro Bustamante, Noelia Díaz‐Troyano, Joan Montaner   +9 more
doaj   +8 more sources

A1AT dysregulation of metabolically stressed hepatocytes by Kupffer cells drives MASH and fibrosis [PDF]

Experimental and Molecular Medicine
Metabolic dysfunction-associated steatohepatitis (MASH) is associated with the activation of Kupffer cells (KCs) and hepatic stellate cells, at which point a metabolically stressed hepatocyte becomes integral to the progression of the disease.
Jeong-Su Park, Jin Lee, Feng Wang, Hwan Ma, Zixiong Zhou, Yong-Sun Lee, Kwangyeon Oh, Haram Lee, Guoyan Sui, Sangkyu Lee, Yoon Mee Yang, Jang-Won Lee, Yong-Ha Ji, Chun-Woong Park, Hwan-Soo Yoo, Bang-Yeon Hwang, Sang-Bae Han, Nan Song, Soohwan Oh, Bumseok Kim, Ekihiro Seki, Jin Tae Hong, Yoon Seok Roh   +22 more
doaj   +6 more sources

FBG1 Is the Final Arbitrator of A1AT-Z Degradation. [PDF]

PLoS ONE, 2015
Alpha-1 antitrypsin deficiency is the leading cause of childhood liver failure and one of the most common lethal genetic diseases. The disease-causing mutant A1AT-Z fails to fold correctly and accumulates in the endoplasmic reticulum (ER) of the liver ...
John H Wen, Hsiang Wen, Katherine N Gibson-Corley, Kevin A Glenn   +3 more
doaj   +5 more sources

Altered polyadenylation site usage in SERPINA1 3’UTR in response to cellular stress affects A1AT protein expression [PDF]

Scientific Reports
Alternative polyadenylation results in different 3’ isoforms of messenger RNA (mRNA) transcripts. Alternative polyadenylation in the 3’ untranslated region (3’UTR) can alter RNA localization, stability and translational efficiency.
F. N. U. Jiamutai, Abigail Hatfield, Austin Herbert, Debarati Majumdar, Vijay Shankar, Lela Lackey   +5 more
doaj   +3 more sources

The Utilization of Alpha 1 Anti-trypsin (A1AT) in Infectious Disease Monitoring and Treatment.

Journal of Microbiology and Infectious Diseases, 2019
Alpha one anti-trypsin (A1AT) is a major serine protease inhibitor found circulating in human blood. A1AT related studies mainly focus on A1AT potential biomarker as well as therapeutic target in non-infectious diseases.
Irene Lorinda Indalao, Agustiningsih Agustiningsih, Kartika Dewi Puspa, Eka Pratiwi, Hartanti Dian Ikawati, Ririn Ramadhany   +5 more
doaj   +5 more sources

Combination of alpha-1 antitrypsin (A1AT) and anti-TNFα as a neuroprotective strategy in the early stages after ischemic stroke. [PDF]

J Cereb Blood Flow Metab
Neuroprotection after ischemic stroke has been focused on targeting one pathway of the ischemic cascade. In this study, we have hypothesized that combination therapy with alpha-1 antitrypsin (A1AT) and a blocker of tumor necrosis factor (TNFα) could be ...
García-Rodríguez P, Ramiro L, Simats A, Ma F, Rosell A, Montaner J.   +5 more
europepmc   +2 more sources

SUN-574 A1AT: Novel Inhibitor of Active PCSK9

Journal of the Endocrine Society, 2020
Heart disease is the principal cause of death and disability for both men and women in the US, accounting for 40% of all annual deaths. African American populations are disproportionately burdened with metabolic diseases, due in part to cholesterol ...
Q. Melendez, C. Wooten, Sumaira Ahmed, Ariel Williams, K. Kimbro, D. Lopez   +5 more
semanticscholar   +2 more sources

Association of A1AT genetic polymorphism and NSCLC: a case- control study in Egyptian population

BMC Medical Genomics, 2023
Background Lung cancer mortality is higher than other forms of cancer. Genetic tendencies in cancer patients have long been known. Given the link between A1ATD and numerous lung disorders, it is worth investigating if this genetic trait is linked to a ...
Aliaa N. El-Dawa, A. Elsaid, S. Refaat, O. El-khawaga   +3 more
semanticscholar   +4 more sources

Assessment of liver fibrosis by transient elastography (Fibroscan®) in patients with A1AT deficiency. [PDF]

Clinics and Research in Hepatology and Gastroenterology, 2019
Alpha-1-antitrypsin deficiency (A1ATD) is a common genetic condition which predisposes to emphysema and liver disorders. It is estimated that 10-15% of homozygous individuals for the Z allele (PiZZ) may develop liver fibrosis. The optimal modalities to detect liver disease in PiZZ adult patients need to be defined. The aim of this prospective study was
O. Guillaud, J. Dumortier, J. Traclet, L. Restier, P. Joly, C. Chapuis‐Cellier, A. Lachaux, J. Mornex   +7 more
semanticscholar   +5 more sources

a1-antitrypsin, a new biomarker of polycystic ovary syndrome by changing its expression and rhythm [PDF]

Journal of Ovarian Research
Background Previous proteomic studies have demonstrated the potential for identifying specific diagnostic biomarkers in the plasma and follicular fluid of patients with polycystic ovary syndrome (PCOS), which was utilized to elucidate the underlying ...
Na Li, Beilei Shen, Wei Cao, RouRou Chen, Rongbo He, Li Qian, Lin Xu, Yu Liu   +7 more
doaj   +2 more sources