Results 11 to 20 of about 3,774 (171)

Role of the alpha-1 antitrypsin in the progression and severity of COVID-19 infection among Saudi patients [PDF]

BMC Infectious Diseases
Background Alpha-1 antitrypsin (A1AT) is involved in pathophysiology of severe COVID-19, including thrombosis expansion. A1AT has anti-inflammatory, tissue-protective, and anticoagulant capabilities.
Rabab A. Ali, Walaa A. Mohammedsaeed, Mohamed Hisham A. Fakher, Hala K. Noor, Yasir M. Al Qurashi   +4 more
doaj   +2 more sources

Investigation of CCL18 and A1AT as potential urinary biomarkers for bladder cancer detection [PDF]

BMC Urology, 2013
BackgroundIn this study, we further investigated the association of two biomarkers, CCL18 and A1AT, with bladder cancer (BCa) and evaluated the influence of potentially confounding factors in an experimental model.MethodsIn a cohort of 308 subjects (102 ...
M. Miyake, S. Ross, Adrienne Lawton, Myron N. Chang, Yunfeng Dai, L. Mengual, A. Alcaraz, E. Giacoia, S. Goodison, C. Rosser   +9 more
semanticscholar   +4 more sources

Immunological and homeostatic pathways of alpha -1 antitrypsin: a new therapeutic potential [PDF]

Frontiers in Immunology
α -1 antitrypsin (A1AT) is a 52 kDa acute-phase glycoprotein belonging to the serine protease inhibitor superfamily (SERPIN). It is primarily synthesized by hepatocytes and to a lesser extent by monocytes, macrophages, intestinal epithelial cells, and ...
Carmen Mazzuca, Carmen Mazzuca, Laura Vitiello, Silvia Travaglini, Fatima Maurizi, Panaiotis Finamore, Simona Santangelo, Amelia Rigon, Marta Vadacca, Silvia Angeletti, Simone Scarlata   +10 more
doaj   +2 more sources

Scavenger receptor class B, type I-mediated uptake of A1AT by pulmonary endothelial cells.

American Journal of Physiology-Lung Cellular and Molecular Physiology, 2015
In addition to exerting a potent anti-elastase function, α-1 antitrypsin (A1AT) maintains the structural integrity of the lung by inhibiting endothelial inflammation and apoptosis. A main serpin secreted in circulation by hepatocytes, A1AT requires uptake by the endothelium to achieve vasculoprotective effects.
A. Lockett, D. Petrusca, M. Justice, Christophe Poirier, K. Serban, N. Rush, M. Kamocka, D. Predescu, S. Predescu, I. Petrache   +9 more
semanticscholar   +4 more sources

Alternative autophagy alleviates A1AT‐Z accrual (949.2)

The FASEB Journal, 2014
Alpha‐1 antitrypsin deficiency is the leading cause of childhood liver failure, one of the most common lethal genetic diseases, and is present in 1 in 2,500 people of European descent. The disease‐causing mutant A1AT‐Z fails to fold correctly and accumulates in the endoplasmic reticulum of the liver, resulting in hepatic fibrosis and hepatocellular ...
J. Wen, Geoff Dankle, Kevin A. Glenn
semanticscholar   +2 more sources

A1AT polymorphisms may be associated with clinical characteristics of retrovirus infections in a mixed ethnic population from the Brazilian Amazon region

International Journal of Infectious Diseases, 2017
Objectives: This study investigated the association of alpha-1-antrypsin deficiency (A1AT; S and Z polymorphisms) with HIV-1 and HTLV-1 infection. Methods: Blood samples from 201 HIV-1-infected and 115 HTLV-1-infected individuals were examined and ...
Thalita Camêlo da Silva Ferreira, Maria Alice Freitas Queiroz, Gustavo Adolfo Argañaraz, Ricardo Ishak, Antonio Carlos Rosário Vallinoto, Enrique Roberto Argañaraz   +5 more
doaj   +2 more sources

Application of Salivary Alpha-1 Antitrypsin in the Diagnosis of Rheumatoid Arthritis: A Pilot Study [PDF]

Medicina
Background and Objective: Rheumatoid arthritis (RA) is an autoimmune disease in which joints are gradually destroyed. Early diagnosis and treatment before joint deformation or destruction is important.
Sang Wan Chung, Seung-Jae Hong
doaj   +2 more sources

Alpha1-antitrypsin counteracts heme-induced endothelial cell inflammatory activation, autophagy dysfunction and death

Redox Biology, 2021
Free heme toxicity in the vascular endothelium is critical for the pathogenesis of hemolytic disorders including sickle cell disease. In the current study, it is demonstrated that human alpha1-antitrypsin (A1AT), a serine protease inhibitor with high ...
Kukuh Madyaningrana, Vijith Vijayan, Christoph Nikolin, Abid Aljabri, Srinu Tumpara, Elena Korenbaum, Harshit Shah, Metodi Stankov, Heiko Fuchs, Sabina Janciauskiene, Stephan Immenschuh   +10 more
doaj   +1 more source

Exogenous alpha 1-antitrypsin down-regulates SERPINA1 expression. [PDF]

PLoS ONE, 2017
The main goal of the therapy with purified human plasma alpha1-antitrypsin (A1AT) is to increase A1AT levels and to prevent lungs from elastolytic activity in patients with PiZZ (Glu342Lys) A1AT deficiency-related emphysema.
Ahmad Karadagi, Helene Johansson, Helen Zemack, Sandeep Salipalli, Lisa-Mari Mörk, Kristina Kannisto, Carl Jorns, Roberto Gramignoli, Stephen Strom, Knut Stokkeland, Bo-Göran Ericzon, Danny Jonigk, Sabina Janciauskiene, Greg Nowak, Ewa C S Ellis   +14 more
doaj   +1 more source

Active trafficking of alpha 1 antitrypsin across the lung endothelium. [PDF]

PLoS ONE, 2014
The homeostatic lung protective effects of alpha-1 antitrypsin (A1AT) may require the transport of circulating proteinase inhibitor across an intact lung endothelial barrier.
Angelia D Lockett, Mary Beth Brown, Nieves Santos-Falcon, Natalia I Rush, Houssam Oueini, Amber J Oberle, Esther Bolanis, Miryam A Fragoso, Daniela N Petrusca, Karina A Serban, Kelly S Schweitzer, Robert G Presson, Michael Campos, Irina Petrache   +13 more
doaj   +1 more source