Results 21 to 30 of about 3,774 (171)

How Can We Improve the Detection of Alpha1-Antitrypsin Deficiency? [PDF]

PLoS ONE, 2015
The Z deficiency in α1-antitrypsin (A1ATD) is an under-recognized condition. Alpha1-antitrypsin (A1AT) is the main protein in the α1-globulin fraction of serum protein electrophoresis (SPE); however, evaluation of the α1-globulin protein fraction has ...
Ilaria Ferrarotti, Beata Poplawska-Wisniewska, Maria Teresa Trevisan, Janine Koepke, Marc Dresel, Rembert Koczulla, Stefania Ottaviani, Raffaele Baldo, Marina Gorrini, Giorgia Sala, Luana Cavallon, Tobias Welte, Joanna Chorostowska-Wynimko, Maurizio Luisetti, Sabina Janciauskiene   +14 more
doaj   +1 more source

Impact of serine protease inhibitor alpha1-antitrypsin on expression of endoplasmic reticulum stress-induced proinflammatory factors in adipocytes

Biochemistry and Biophysics Reports, 2021
Obesity-induced endoplasmic reticulum (ER) stress contributes to low-grade chronic inflammation in adipose tissue and may cause metabolic disorders such as diabetes mellitus and dyslipidemia.
Yukari Ando, Akito Kuroda, Kazuya Kusama, Takeshi Matsutani, Akihisa Matsuda, Kazuhiro Tamura   +5 more
doaj   +1 more source

Novel Vascularized Human Liver Organoids for Modeling Alcohol-Induced Liver Injury and Developing Hepatoprotective Therapy. [PDF]

Adv Sci (Weinh)
This study successfully engineered vascularized liver organoids (3HLOs) by co‐culturing human reprogrammed hepatocyte‐like cells (hrHLs) with human umbilical vein endothelial cells (HUVECs) and human umbilical mesenchymal stem cells (HUMSCs). Upon implantation, the 3HLOs established functional vascular anastomosis with the host circulation and ...
Yang K, Chu X, Wang X, Zhang W, Lu J, Xu C, Hu S, Pan G, Yang CT, Zhang X, Li S, Guo Z, Liu H, Ge G.   +13 more
europepmc   +2 more sources

Label-free quantitative proteomics reveals aberrant expression levels of LRG, C9, FN, A1AT and AGP1 in the plasma of patients with colorectal cancer

Clinical Proteomics, 2023
Background Colorectal cancer (CRC) is one of the major causes of cancer-related death worldwide. Although commercial biomarkers of CRC are currently available, they are still lacking in terms of sensitivity and specificity; thus, searching for reliable ...
Chris Verathamjamras, Juthamard Chantaraamporn, Thiwaree Sornprachum, P. Mutapat, D. Chokchaichamnankit, Kanokwan Mingkwan, Virat Luevisadpibul, C. Srisomsap, S. Chutipongtanate, Jisnuson Svasti, V. Champattanachai   +10 more
semanticscholar   +1 more source

Optimal alpha-1 antitrypsin level cutoffs for genotype identification in patients with chronic liver disease

Hepatology Communications, 2023
Background:. Controversy exists whether alpha-1 antitrypsin (A1AT) genotype testing should be performed as a first-line screening for A1AT heterozygous variants. Methods:.
Sameer Prakash, Arvind R. Murali
doaj   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Alpha 1-antitrypsin does not inhibit human monocyte caspase-1. [PDF]

PLoS ONE, 2015
BACKGROUND:Alpha 1-antitrypsin (A1AT) is a 52 kDa serine protease inhibitor produced largely by hepatocytes but also by mononuclear phagocytes. A1AT chiefly inhibits neutrophil elastase and proteinase-3 but has also been reported to have immune ...
Mohd Akhlakur Rahman, Srabani Mitra, Anasuya Sarkar, Mark D Wewers   +3 more
doaj   +1 more source

In Vitro Investigations on Optimizing and Nebulization of IVT-mRNA Formulations for Potential Pulmonary-Based Alpha-1-Antitrypsin Deficiency Treatment

Pharmaceutics, 2021
In vitro-transcribed (IVT) mRNA has come into focus in recent years as a potential therapeutic approach for the treatment of genetic diseases. The nebulized formulations of IVT-mRNA-encoding alpha-1-antitrypsin (A1AT-mRNA) would be a highly acceptable ...
Shan Guan, Max Darmstädter, Chuanfei Xu, Joseph Rosenecker   +3 more
doaj   +1 more source

Proteoform Profiles Reveal That Alpha-1-Antitrypsin in Human Serum and Milk Is Derived From a Common Source

Frontiers in Molecular Biosciences, 2022
The Alpha-1-Antitrypsin (A1AT) protein is an important protease inhibitor highly abundant in human serum and other body fluids. Additional to functioning as a protease inhibitor, A1AT is an important acute phase protein.
Shelley Jager, Shelley Jager, Dario A. T. Cramer, Dario A. T. Cramer, Max Hoek, Max Hoek, Nadia J. Mokiem, Nadia J. Mokiem, Britt J. van Keulen, Johannes B. van Goudoever, Kelly A. Dingess, Kelly A. Dingess, Kelly A. Dingess, Albert J. R. Heck, Albert J. R. Heck   +14 more
doaj   +1 more source

α-Linoleic Acid Enhances the Capacity of α1-Antitrypsin to Inhibit Lipopolysaccharide-Induced IL-1β in Human Blood Neutrophils

Molecular Medicine, 2016
Alphal-antitrypsin (A1AT, SERPINA1), a major circulating inhibitor of neutrophil elastase (NE) and protelnase-3 (PR3), has been proposed to reduce the processing and release of IL-1β.
Nupur Aggarwal, Elena Korenbaum, Ravi Mahadeva, Stephan Immenschuh, Veronika Grau, Charles A Dinarello, Tobias Welte, Sabina Janciauskiene   +7 more
doaj   +1 more source