Results 61 to 70 of about 3,774 (171)
, 2018 BackgroundLittle is known about pulmonary complications induced by Sulfur Mustard (SM), as a chemical warfare agent, especially considering its long term effects.
Maryam Nikoonejad +5 more
semanticscholar +1 more source
ABCA12 Frameshift Deletion in Domestic Cats With Ichthyosis Fetalis
Veterinary Dermatology, EarlyView.ABSTRACT Background Ichthyosis fetalis (IF), also known as harlequin ichthyosis, is a rare and often fatal autosomal recessive congenital skin disorder. It is characterized by thickened, hard skin plaques and deep skin fissures that limit mobility and cause malformations of the eyes, lips and ears.
Jeanna M. Blake +2 more
wiley +1 more source
Veterinary Dermatology, EarlyView.ABSTRACT Background Advances in transcriptomics have driven the demand for minimally invasive, reproducible and high‐yield skin sampling methods, particularly for studying inflammatory skin diseases in companion animals. Hypothesis/Objectives We tested tolerability, feasibility and RNA quantity and quality of three minimally invasive skin sampling ...
Ina Herrmann +2 more
wiley +1 more source
Identification of a rare p.G320R alpha-1-antitrypsin variant in emphysema and lung cancer patients
Genetics and Molecular Biology, 2010 The alpha-1-antitrypsin (A1AT) gene is highly polymorphic, with more than 100 genetic variants identified of which some can affect A1AT protein concentration and/or function and lead to pulmonary and/or liver disease.
Mila Ljujic +6 more
doaj
, 2017 61 The aim of this study was to examine oxidative stress and low level of alpha62 1-antitrypsin (A1AT) in primary Sjögren's syndrome (pSS), and evaluate the 63 associated autoreactivity against unmodified and their 4-hydroxy-2-nonenal (HNE)64 modified ...
Yu-Sheng Chang +10 more
semanticscholar +1 more source
Cell‐protective mechanisms of alpha 1 antitrypsin (A1AT) in the lung endothelium
The FASEB Journal, 2009 Recent studies uncovered non‐cannonical functions of A1AT that lead to cellular protection from apoptosis and inflammation, including suppression of cigarette smoke (CS)‐induced increases in TNFα. We set out to investigate the mechanisms by which A1AT antagonizes TNFα?in vivo and in primary lung endothelial ...
Angelia Denise Lockett +4 more
openaire +1 more source
Prevalence and Spectrum of Chronic Liver Disease Among Patients Seeking Health Care in Ghana
Liver International, Volume 46, Issue 3, March 2026.ABSTRACT Background Chronic liver diseases (CLD) leading to liver fibrosis and cirrhosis are a major cause of morbidity and mortality in sub‐Saharan Africa and pose a significant burden on its health care systems. We aimed to elucidate the prevalence of fibrosis/cirrhosis in patients seeking health care in Kumasi, Ghana, and its underlying aetiologies.
Felix Lehmann +19 more
wiley +1 more source
Misfolding linked mutations of SERPINA1 gene are uncommon in preeclampsia
Archives of Medicine and Health Sciences, 2019 Background: Alpha-1 antitrypsin (A1AT) is a protease inhibitor that plays an important role in regulating oxidative stress in preeclampsia (PE). Recent studies have shown that A1AT is misfolded in PE.
Chandrakala Nagarajappa +2 more
doaj +1 more source
Cancer Medicine, Volume 15, Issue 2, February 2026.ABSTRACT Background Lung cancer remains the leading cause of cancer‐related mortality worldwide, highlighting the urgent need for earlier detection within real‐world screening and patient management pathways. Recent advances in multi‐omics technologies have created new opportunities for identifying biomarkers associated with early‐stage lung cancer ...
Fan Bu, Zhi‐Qiang Ling
wiley +1 more source
α1-antitrypsin mitigates NLRP3-inflammasome activation in amyloid β1–42-stimulated murine astrocytes
Journal of Neuroinflammation, 2018 Background Neuroinflammation has an essential impact on the pathogenesis and progression of Alzheimer’s disease (AD). Mostly mediated by microglia and astrocytes, inflammatory processes lead to degeneration of neuronal cells.
Taraneh Ebrahimi +8 more
doaj +1 more source