Results 61 to 70 of about 2,894 (182)
Allergy, Asthma & Clinical Immunology, 2011 Alpha-1-antitrypsin (A1AT) deficiency is a genetic disease characterized by low levels and/or function of A1AT protein. A1AT deficiency can result in the development of COPD, liver disease, and certain skin conditions.
Ringenbach Michael R +4 more
doaj +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, Volume 20, Issue 3, Page 668-687, March 2026.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Identification of a rare p.G320R alpha-1-antitrypsin variant in emphysema and lung cancer patients
Genetics and Molecular Biology, 2010 The alpha-1-antitrypsin (A1AT) gene is highly polymorphic, with more than 100 genetic variants identified of which some can affect A1AT protein concentration and/or function and lead to pulmonary and/or liver disease.
Mila Ljujic +6 more
doaj
Diverse immunological roles of liver‐resident immune cells in liver diseases
Precision Medical Sciences, Volume 15, Issue 1, Page 4-17, March 2026.Based on their origin and functional characteristics, LRICs can be classified into four categories. These cells differ in the focus of their immune functions in liver diseases, yet all exhibit the characteristic of functional bidirectionality.
Zhengyi Fan +4 more
wiley +1 more source
Cell‐protective mechanisms of alpha 1 antitrypsin (A1AT) in the lung endothelium
The FASEB Journal, 2009 Recent studies uncovered non‐cannonical functions of A1AT that lead to cellular protection from apoptosis and inflammation, including suppression of cigarette smoke (CS)‐induced increases in TNFα. We set out to investigate the mechanisms by which A1AT antagonizes TNFα?in vivo and in primary lung endothelial ...
Angelia Denise Lockett +4 more
openaire +1 more source
Methods in Ecology and Evolution, Volume 17, Issue 3, Page 850-862, March 2026.Abstract Accurate and reliable estimation of wildlife population density is fundamental to effective conservation and management. While camera traps show potential for monitoring ground‐dwelling mammal densities, labour‐intensive data processing remains a significant constraint. Ideally, conservation efforts would benefit from the continuous monitoring
Yoshihiro Nakashima +2 more
wiley +1 more source
Prevalence and Spectrum of Chronic Liver Disease Among Patients Seeking Health Care in Ghana
Liver International, Volume 46, Issue 3, March 2026.ABSTRACT Background Chronic liver diseases (CLD) leading to liver fibrosis and cirrhosis are a major cause of morbidity and mortality in sub‐Saharan Africa and pose a significant burden on its health care systems. We aimed to elucidate the prevalence of fibrosis/cirrhosis in patients seeking health care in Kumasi, Ghana, and its underlying aetiologies.
Felix Lehmann +19 more
wiley +1 more source
Association of A1AT genetic polymorphism and NSCLC: a case- control study in Egyptian population [PDF]
, 2023 Aliaa N. El-Dawa +3 more
openalex +1 more source
Misfolding linked mutations of SERPINA1 gene are uncommon in preeclampsia
Archives of Medicine and Health Sciences, 2019 Background: Alpha-1 antitrypsin (A1AT) is a protease inhibitor that plays an important role in regulating oxidative stress in preeclampsia (PE). Recent studies have shown that A1AT is misfolded in PE.
Chandrakala Nagarajappa +2 more
doaj +1 more source
Label-free quantitative proteomics reveals aberrant expression levels of LRG, C9, FN, A1AT and AGP1 in the plasma of patients with colorectal cancer [PDF]
, 2023 Chris Verathamjamras +10 more
openalex +1 more source