Results 21 to 30 of about 113,965,924 (221)

Safety, Immunogenicity, and Protective Efficacy of an H5N1 Chimeric Cold-Adapted Attenuated Virus Vaccine in a Mouse Model

Viruses, 2021
H5N1 influenza virus is a threat to public health worldwide. The virus can cause severe morbidity and mortality in humans. We constructed an H5N1 influenza candidate virus vaccine from the A/chicken/Guizhou/1153/2016 strain that was recommended by the ...
Weiyang Sun, Zhenfei Wang, Yue Sun, Dongxu Li, Menghan Zhu, Menglin Zhao, Yutian Wang, Jiaqi Xu, Yunyi Kong, Yuanguo Li, Na Feng, Tiecheng Wang, Yongkun Zhao, Songtao Yang, Yuwei Gao, Xianzhu Xia   +15 more
doaj   +1 more source

CD4⁺ T-cell responses directed towards A/H5N1-derived haemagglutinin peptides increase in patients with seasonal influenza A virus infection. [PDF]

Clin Transl Immunology
Abstract Objectives Recent outbreak of influenza A/H5N1 viral infections in birds and mammals worldwide prompted renewed concerns over an emerging H5N1‐related influenza pandemic in the generally immunologically‐naive global population. Cross‐reactive CD4+ T cells between A/H1N1 and A/H5N1 subtypes targeting internal and surface influenza proteins have
Allen LF, Rowntree LC, Jenzen M, Hagen RR, Croft NP, James F, Martin GE, Purcell AW, Illing PT, Tong SYC, Cheng AC, Kotsimbos TC, Trubiano JA, Kedzierska K, Nguyen THO.   +14 more
europepmc   +2 more sources

Differential Impact of Specific Amino Acid Residues on the Characteristics of Avian Influenza Viruses in Mammalian Systems

Pathogens, 2022
Avian influenza virus (AIV) H9N2 was declared to be endemic in birds of the Middle East, in particular in Egypt, with multiple cases of human infections.
Dayly Mashaal, Sara H. Mahmoud, Christin Müller, Noura M. Abo Shama, Amal Abo Kamer, Ahmed A. Abdelaziz, Mohamed A. Ali, Stephan Pleschka, Ahmed Mostafa   +8 more
doaj   +1 more source

A Single Immunization with Soluble Recombinant Trimeric Hemagglutinin Protects Chickens against Highly Pathogenic Avian Influenza Virus H5N1 [PDF]

, 2010
Background: The highly pathogenic avian influenza (HPAI) virus H5N1 causes multi-organ disease and death in poultry, resulting in significant economic losses in the poultry industry.
Dep Infectieziekten Immunologie, Robert P de Vries, Vries, R.P., de, Rigter, A., Rottier, P.J.M., Cornelissen, A.H.M., de Vries, R.P., Cornelissen, L.A.H.M., Alan Rigter, Cornelis A M de Haan, Strategic Infection Biology, de Haan, C.A.M., Haan, C.A.M., de, de Boer-Luijtze, E.A., Boer-Luijtze, E.A., de, Lisette A H M Cornelissen, Els A de Boer-Luijtze, Peter J M Rottier   +17 more
core   +3 more sources

Proinflammatory cytokine responses induced by influenza A (H5N1) viruses in primary human alveolar and bronchial epithelial cells

Respiratory Research, 2005
Background Fatal human respiratory disease associated with influenza A subtype H5N1 has been documented in Hong Kong, and more recently in Vietnam, Thailand and Cambodia. We previously demonstrated that patients with H5N1 disease had unusually high serum
Poon LLM, Long HT, Chan RWY, Chan YO, Nicholls JM, Tsao SW, Chui WH, Cheung CY, Chan MCW, Guan Y, Peiris JSM   +10 more
doaj   +1 more source

Novel phylogenetic algorithm to monitor human tropism in Egyptian H5N1-HPAIV reveals evolution toward efficient human-to-human transmission [PDF]

, 2013
Years of endemic infections with highly pathogenic avian influenza (HPAI) A subtype H5N1 virus in poultry and high numbers of infections in humans provide ample opportunity in Egypt for H5N1-HPAIV to develop pandemic potential.
Ursula Dietrich (351656), Perovic, Vladimir R., Dietrich, Ursula, Veljković, Nevena V., Veljkovic, Nevena, Ursula Dietrich, Claude P. Muller (106167), Nevena Veljkovic, Henry L. Niman (407613), Dusan D Tosic, Nevena Veljkovic (338669), Veljko Veljkovic (315720), Sanja Glisic, Sanja Glisic (168160), Muller, Claude P., Dusan D. Tosic (407614), Vladimir R. Perovic (407612), Niman, Henry L., Veljkovic, Veljko, Tosic, Dusan D., Vladimir R Perovic, Claude P Muller, Veljko Veljkovic, Henry L Niman, Glisic, Sanja   +24 more
core   +1 more source

Combining spatial-temporal and phylogenetic analysis approaches for improved understanding on global H5N1 transmission. [PDF]

PLoS ONE, 2010
BACKGROUND: Since late 2003, the highly pathogenic influenza A H5N1 had initiated several outbreak waves that swept across the Eurasia and Africa continents.
Lu Liang, Bing Xu, Yanlei Chen, Yang Liu, Wuchun Cao, Liqun Fang, Limin Feng, Michael F Goodchild, Peng Gong   +8 more
doaj   +1 more source

Highly Pathogenic Avian Influenza A (H5N1) Virus in Swans, Central China, 2021

Microbiology Spectrum, 2022
Six highly pathogenic avian influenza (HPAI) H5N1 viruses (clade 2.3.4.4b) were detected in migratory birds in Hubei Province in November 2021. Phylogenetic analysis indicated that the viruses in the study included two different reassortants between H5N1
Xianliang Ke, Zhongzi Yao, Yangyu Tang, Mengting Yang, Yong Li, Guoxiang Yang, Jing Chen, Guang Chen, Wei Feng, Hesong Zheng, Quanjiao Chen   +10 more
doaj   +1 more source

H5N1 Viruses and Vaccines

PLoS Pathogens, 2007
The establishment and spread of highly pathogenic avian influenza (HPAI) viruses of the H5N1 subtype in birds and coincident infections in humans since 2003 have raised concerns that we may be facing an influenza pandemic caused by an H5N1 influenza virus. In this brief Opinion piece, we consider the pandemic threat posed by H5N1 viruses and review the
Kanta Subbarao, Catherine Luke
openaire   +4 more sources

Seroprevalence of antibodies to highly pathogenic avian influenza A (H5N1) virus among close contacts exposed to H5N1 cases, China, 2005-2008. [PDF]

PLoS ONE, 2013
To assess the extent of highly pathogenic avian influenza (HPAI) A (H5N1) virus transmission, we conducted sero-epidemiologic studies among close contacts exposed to H5N1 cases in mainland China during 2005-2008.
Qiaohong Liao, Tian Bai, Lei Zhou, Sirenda Vong, Junqiao Guo, Wei Lv, Libo Dong, Nijuan Xiang, Zi Li, Yang Huai, Jianfang Zhou, Xiaodan Li, Ray Y Chen, Zhen Xu, Timothy M Uyeki, Yuelong Shu, Hongjie Yu   +16 more
doaj   +1 more source