Results 51 to 60 of about 113,965,924 (221)

Reverse genetics-derived cattle H5N1 virus from Clade 2.3.4.4b shows enhanced systemic infectivity and pathogenicity than an older Clade 1 H5N1 virus in BALB/c mice

Emerging Microbes and Infections
The newly emerged avian influenza A H5N1 Clade 2.3.4.4b can infect dairy cows and shed live virus in their milk. Sporadic cattle-to-human infections have been reported, highlighting the urgent need to understand its pathogenesis in mammals.
Na Xiao, Xiang Yong Oong, Yanxia Chen, Can Li, Howard Chun-Ho Chung, Pui Wang, Zhanhong Ye, Alvin Hiu-Chung Lam, Jianpiao Cai, Wenchen Song, Andrew Chak-Yiu Lee, Hin Chu, Kin-Hang Kok, Jasper Fuk-Woo Chan, Shuofeng Yuan, Honglin Chen, Kwok-Yung Yuen, Anna Jin-Xia Zhang   +17 more
doaj   +1 more source

The Influenza Virus H5N1 Infection Can Induce ROS Production for Viral Replication and Host Cell Death in A549 Cells Modulated by Human Cu/Zn Superoxide Dismutase (SOD1) Overexpression

Viruses, 2016
Highly pathogenic H5N1 infections are often accompanied by excessive pro-inflammatory response, high viral titer, and apoptosis; as such, the efficient control of these infections poses a great challenge.
Xian Lin, Ruifang Wang, Wei Zou, Xin Sun, Xiaokun Liu, Lianzhong Zhao, Shengyu Wang, Meilin Jin   +7 more
doaj   +1 more source

A statistical phylogeography of influenza A H5N1 [PDF]

Proceedings of the National Academy of Sciences, 2007
The geographic diffusion of highly pathogenic influenza A H5N1 has largely been traced from the perspective of the virus's victims. Birds of a variety of avian orders have been sampled across localities, and their infection has been identified by a general genetic test.
Robert G, Wallace, Hoangminh, Hodac, Richard H, Lathrop, Walter M, Fitch   +3 more
openaire   +2 more sources

Generation of Nasal Cell‐Derived Human Alveolar Organoids and Organoid‐Macrophage Assembloids for in Vitro Lung Modeling

Advanced Science, EarlyView.
This study demonstrates the generation of human alveolar organoids from nasal cells, which, when co‐cultured with monocyte‐derived macrophages, promotes maturation of both components and forms alveolar assembloids resembling native alveoli. These alveolar organoids and assembloids offer accessible, physiologically relevant in vitro systems for ...
Man Chun Chiu, Shuxin Zhang, Cun Li, Yifei Yu, Zhixin Wan, Jingjing Huang, Wei Xue, Ying Zhou, Xiaoxin Zhu, Qiaoshuai Lan, Jiali Wu, Zijun Zhao, Yuhong Liu, Xinjie Meng, Lin Huang, Hin Chu, Honglin Chen, Kelvin Kai‐Wang To, Kwok Yung Yuen, Jie Zhou   +19 more
wiley   +1 more source

Influenza A (H5N1) [PDF]

pharma-kritik, 2005
In Südostasien sind bei über 100 Menschen durch das aviäre Influenza-A-(H5N1)-Virus verursachte Erkrankungen aufgetreten. Im aktuellen Plan zur Eindämmung einer allfälligen (H5N1)-Pandemie spielt Oseltamivir eine wichtige Rolle; sichere Fakten zu dieser Strategie fehlen aber.
openaire   +1 more source

Chicken Pulmonary MicroRNAs Targeting the PB2 (Segment 1) of Avian Influenza Virus

Animal Research and One Health, EarlyView.
The PB2 segment of H5N1 is essential for replication and host adaptation. We screened 200 miRNAs and identified five (gga‐miR‐17‐3p, gga‐miR‐29a‐5p, gga‐miR‐1718, gga‐miR‐16c‐5p, and gga‐miR‐1744‐5p) using thermodynamic stability of heteroduplex, seed sequence complementarity, conservation, and accessibility, offering insights into host antiviral ...
Akanksha Choudhary, Nidhishree N. S, Rakesh Kumar Pundir, Muhasin Asaf V. N, Anamika Mishra, Ashwin Ashok Raut, Megha Agarwal, Amod Kumar   +7 more
wiley   +1 more source

The Role of miRNAs in Chicken Immune Regulation and Prospects for Disease‐Resistant Breeding

Animal Research and One Health, EarlyView.
A schematic workflow illustrating the screening of disease‐resistant miRNAs and the generation of miRNA‐based disease‐resistant chickens via PGC‐mediated germline genome editing. ABSTRACT MicroRNAs (miRNAs) are emerging as pivotal regulators of the immune system, playing a decisive role in shaping disease resistance in chicken.
Qiangzhou Wang, Weiran Wu, Qingqing Cai, Jiaxing Wang, Qi Gao, Muhammad Iftikhar, Yulin Bi, Hao Bai, Lihong Gu, Guobin Chang, Shihao Chen   +10 more
wiley   +1 more source

Knowledge discovery from mining the association between H5N1 outbreaks and environmental factors [PDF]

, 2010
The global spread of highly pathogenic avian influenza H5N1 in poultry, wild birds and humans, poses a significant panzootic threat and a serious public health risk.
Si, Y., Wang, Tiejun; id_orcid, Prins, H. H T, Wang, T., Si, Y. L., Skidmore, A.K., Wang, Tiejun, Skidmore, A. K., Prins, H.H.T.   +8 more
core  

H5N1/highly pathogenic avian influenza in Cambodia : evaluating poultry movement and the extent of interaction between poultry and humans [PDF]

Since 2003, highly pathogenic avian influenza (HPAI), subtype H5N1, has spread across the Asian, African and European continents at an exceptional rate.
Van Kerkhove, Maria D
core   +1 more source

Metal nanostructure‐coupled label‐free localized surface plasmon resonance biosensors for rapid and sensitive disease diagnosis

BMEMat, EarlyView.
LSPR biosensing enables rapid, sensitive, and low‐sample‐volume detection of biomarkers, with broad applications in diagnosing cancer, infectious, and chronic diseases. Advances in nanostructure design, micro/nanofabrication, and microfluidic integration have expanded the potential of LSPR sensors in biomedical diagnostics.
Zhaoxin Geng, Yunfei Sha, Jiongyan Yang, Hongru Yang, Xiao Liang   +4 more
wiley   +1 more source