Results 101 to 110 of about 131,610 (332)
Advanced Science, EarlyView.Lipid droplets (LDs) protect the heart against lipotoxicity in cardiac ischemia/reperfusion (I/R) injury; however, they are insufficient to prevent cardiomyocyte death. Seipin plays a central role in the insufficient formation of LDs, subsequent lipotoxicity, and myocardial injury during cardiac I/R injury.
Changyun Liu +13 more
wiley +1 more source
Evaluation of Gene Therapy as an Intervention Strategy to Treat Brain Injury from Stroke
Frontiers in Molecular Neuroscience, 2016 Stroke is a leading cause of death and disability, with a lack of treatments available to prevent cell death, regenerate damaged cells and pathways, or promote neurogenesis.
Amanda J Craig, Gary D Housley
doaj +1 more source
Exercise enhances motor skill learning by neurotransmitter switching in the adult midbrain. [PDF]
, 2020 Physical exercise promotes motor skill learning in normal individuals and those with neurological disorders but its mechanism of action is unclear. We find that one week of voluntary wheel running enhances the acquisition of motor skills in normal adult ...
Li, Hui-Quan, Spitzer, Nicholas C
core
Advanced Science, EarlyView.By profiling the spatiotemporal hepatic landscape of CHB mouse models, the originally peri‐portal localized KCs migrated to the peri‐central in a CXCL9‐CXCR3‐dependent manner, facilitating their interaction with HBV+ hepatocytes. The interaction promoted LMD in KCs through ASGR1‐induced LXRα degradation, which, in turn, induced CSC formation via Stat3 ...
Jingqi Shi +18 more
wiley +1 more source
Advanced Science, EarlyView.Aged HSF1 muscle‐specific knockout mice show deteriorated muscle atrophy and metabolic dysfunction, while active HSF1 overexpression improves muscle function via activating SIRT3 to deacetylate both PGC1α1 and PGC1α4, which boosts mitochondrial function and muscle hypertrophy in a fiber‐type specific manner, and induces FNDC5/Irisin for tissue ...
Jun Zhang +18 more
wiley +1 more source
Cellular unfolded protein response against viruses used in gene therapy
Frontiers in Microbiology, 2014 Viruses are excellent vehicles for gene therapy due to their natural ability to infect and deliver the cargo to specific tissues with high efficiency.
Dwaipayan eSen +3 more
doaj +1 more source
Astrocytic PERK Deficiency Drives Prefrontal Circuit Dysfunction and Depressive‐Like Behaviors
Advanced Science, EarlyView.Chen et al. show that the endoplasmic reticulum (ER) stress sensor PERK is downregulated in prefrontal cortex (PFC) astrocytes in major depressive disorder and in chronic‐stress mouse models. In young mice, astrocyte‐specific PERK loss reduces the synaptogenic cue thrombospondin‐1 (TSP1), leading to synaptic and circuit deficits and depressive‐like ...
Kai Chen +8 more
wiley +1 more source
An AAV-Based NF-κB-Targeting Gene Therapy (rAAV-DMP-miR533) to Inflammatory Diseases
Journal of Inflammation Research, 2022 Tao Luo,1 Yile Wang,1 Hailin Tang,1 Fei Zhou,2 Ying Chen,3 Bing Pei,4 Jinke Wang1 1State Key Laboratory of Bioelectronics, Southeast University, Nanjing, 210096, People’s Republic of China; 2School of Food Engineering and Biotechnology, Hanshan Normal ...
Luo T +6 more
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Frontiers in Neural Circuits, 2012 Recording of identified neuronal network activity using genetically encoded calcium indicators (GECIs) requires labeling that is cell type-specific and bright enough for the detection of functional signals.
Bernd eKuhn +10 more
doaj +1 more source
, 2007 We study magnetic domain patterns in ferromagnetic thin films by numerical simulations for a simple Ising-like model. Magnetic domain patterns after quench demonstrate various types of patterns depending on the field sweep rate and parameters of the ...
Katsuhiro Nakamura, Kazue Kudo, M. Mino
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