Results 21 to 30 of about 144,727 (384)
Neutrophils in ANCA-associated vasculitis: Mechanisms and implications for management
Frontiers in Pharmacology, 2022 Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a group of systemic autoimmune diseases, which is typified by inflammatory necrosis predominantly affecting the small vessels and often accompanied by positive ANCA.
Shangqing Ge +16 more
doaj +1 more source
Wild type AAV, recombinant AAV, and Adenovirus super infection impact on AAV vector mobilization [PDF]
, 2020 AbstractRecombinant Adeno-associated viral vector (rAAV) mobilization is a largely theoretical process in which intact AAV vectors spread or “mobilize” from transduced cells and infect additional cells within, or external, of the initial host. This process can be replication independent (vector alone), or replication-dependent (de novo rAAV production ...
Song, Liujiang +2 more
openaire +2 more sources
Nature Communications, 2021 Adeno-associated virus (AAV)-mediated CRISPR-Cas9 editing holds promise to treat many diseases. The immune response to bacterial-derived Cas9 has been speculated as a hurdle for AAV-CRISPR therapy. However, immunological consequences of AAV-mediated Cas9
Chady H. Hakim +23 more
semanticscholar +1 more source
Overcoming innate immune barriers that impede AAV gene therapy vectors.
Journal of Clinical Investigation, 2021 The field of gene therapy has made considerable progress over the past several years. Adeno-associated virus (AAV) vectors have emerged as promising and attractive tools for in vivo gene therapy.
Manish Muhuri +6 more
semanticscholar +1 more source
Surface immobilization of hexa-histidine-tagged adeno-associated viral vectors for localized gene delivery. [PDF]
, 2010 Adeno-associated viral (AAV) vectors, which are undergoing broad exploration in clinical trials, have significant promise for therapeutic gene delivery because of their safety and delivery efficiency.
Bethi, SR +5 more
core +2 more sources
Progress in the use of adeno-associated viral vectors for gene therapy [PDF]
, 2004 The development of safe and efficient gene transfer vectors is crucial for the success of gene therapy trials. A viral vector system promising to meet these requirements is based on the apathogenic adeno-associated virus (AAV-2), a member of the ...
Braun-Falco, M., Buning, H., Hallek, M.
core +1 more source
Sex significantly influences transduction of murine liver by recombinant adeno-associated viral vectors through an androgen-dependent pathway. [PDF]
, 2003 A systematic evaluation of the influence of sex on transduction by recombinant adeno-associated viral vector (rAAV) indicated that transgene expression after liver-targeted delivery of vector particles was between 5- to 13-fold higher in male mice ...
Davidoff, AM +4 more
core +1 more source
To transduce a zebra finch: interrogating behavioral mechanisms in a model system for speech. [PDF]
, 2017 The ability to alter neuronal gene expression, either to affect levels of endogenous molecules or to express exogenous ones, is a powerful tool for linking brain and behavior. Scientists continue to finesse genetic manipulation in mice.
Heston, Jonathan B, White, Stephanie A
core +1 more source
Human Immune Responses to Adeno-Associated Virus (AAV) Vectors
Frontiers in Immunology, 2020 Recombinant adeno-associated virus (rAAV) vectors are one of the most promising in vivo gene delivery tools. Several features make rAAV vectors an ideal platform for gene transfer. However, the high homology with the parental wild-type virus, which often
G. Ronzitti, D. Gross, F. Mingozzi
semanticscholar +1 more source
Frontiers in Behavioral Neuroscience, 2015 Techniques to genetically manipulate the activity of defined neuronal subpopulations have been useful in elucidating function, however applicability to translational research beyond transgenic mice is limited. Subtype targeted transgene expression can be
Heinrich S Gompf +4 more
doaj +1 more source