Results 31 to 40 of about 79,958 (292)

Adeno-Associated Virus (AAV) - Based Gene Therapies for Retinal Diseases: Where are We?

The Application of Clinical Genetics, 2023
Divya Ail, Hugo Malki, Emilia A Zin, Deniz Dalkara Sorbonne Université, INSERM, CNRS, Department of Therapeutics, Institut de la Vision, Paris, 75012, FranceCorrespondence: Divya Ail, Department of Therapeutics, Institut de la Vision, 17 Rue Moreau ...
Ail D, Malki H, Zin EA, Dalkara D
doaj  

AAV-expressed serum mAb retains full neutralization activity.

, 2018
(A) Standard neutralization regression analyses are shown for ITS01 (upper) and ITS06.02 (lower) from purified mAb (red, open circles) or sera from AAV injected rhesus macaques (blue, open squares) (n = 6).
Rosemarie D. Mason (90621), Yi Zhang (9093), Sandeep Narpala (517528), Lingshu Wang (3204129), Madeleine F. Jennewein (2564638), Cheng Cheng (68821), Galit Alter (91383), Hugh C. Welles (3174969), Alejandro B. Balazs (244312), Jeffrey D. Lifson (140183), John R. Mascola (229761), Mario Roederer (5259), John-Paul Todd (6054251), Adrian B. McDermott (635782)   +13 more
core   +1 more source

Targeted genetic manipulations of neuronal subtypes using promoter-specific combinatorial AAVs for use in wild-type animals

Frontiers in Behavioral Neuroscience, 2015
Techniques to genetically manipulate the activity of defined neuronal subpopulations have been useful in elucidating function, however applicability to translational research beyond transgenic mice is limited. Subtype targeted transgene expression can be
Heinrich S Gompf, Evgeny A Budygin, Evgeny A Budygin, Patrick M Fuller, Caroline E Bass   +4 more
doaj   +1 more source

Emerging Concepts and Challenges in Rheumatoid Arthritis Gene Therapy

Biomedicines, 2020
Rheumatoid arthritis (RA) is a systemic inflammatory joint disease affecting about 1% of the population worldwide. Current treatment approaches do not ensure a cure for every patient.
Andrei A. Deviatkin, Yulia A. Vakulenko, Ludmila V. Akhmadishina, Vadim V. Tarasov, Marina I. Beloukhova, Andrey A. Zamyatnin Jr., Alexander N. Lukashev   +6 more
doaj   +1 more source

The Potential of eCD4-Ig, Delivered by Adeno-Associated Virus (AAV) Vector as a Novel Vaccine for HIV/AIDS Infection

Scripta Score Scientific Medical Journal, 2021
Background: HIV/AIDS has already become one of the world's major health issues taking its toll on millions of lives each year. Developing an HIV vaccine with excellent efficacy has become a global urgency that must be addressed immediately.
Ghea Mangkuliguna
doaj   +1 more source

Piezo2 Mediates a Vicious Cycle of “Mechanical Homeostasis Imbalance—Inflammation” in Sensory Nerves and the Cartilage Endplate

Advanced Science, EarlyView.
In a lumbar spine instability model, dorsal root ganglion cells mediate the perception of relevant mechanical stresses through Piezo2 and subsequently release CGRP. CGRP activates the NF‐κB signaling pathway in cartilage endplate cells through the receptor RAMP1.
Hanpeng Xu, Wen Geng, Zhi Du, Yifan Du, Di Wu, Bide Tong, Huaizhen Liang, Xingyu Zhou, Zixuan Ou, Junyu Wei, Kun Wang, Yu Song, Wenbin Hua, Yan Xu, Wencan Ke, Bingjin Wang, Cao Yang   +16 more
wiley   +1 more source

Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui, Zhencong Chen, Guangyao Shan, Zhengyang Hu, Xing Jin, Jiaqi Liang, Yanjun Yi, Jiacheng Yin, Haochun Shi, Xifei Jiang, Junjie Xi, Zongwu Lin, Cheng Zhan, Fenghao Sun, Wei Jiang   +14 more
wiley   +1 more source

Recombinant human myelin-associated glycoprotein promoter drives selective AAV-mediated transgene expression in oligodendrocytes

Frontiers in Molecular Neuroscience, 2016
Leukodystrophies are hereditary central white matter disorders caused by oligodendrocyte dysfunction. Recent clinical trials for some of these devastating neurological conditions have employed an ex vivo gene therapy approach that showed improved ...
Georg evon Jonquieres, Claudia Bettina Klugmann, Dominik eFröhlich, Xin eWen, Anne Editha Harasta, Roshini eRamkumar, Ziggy HT Spencer, Gary D Housley, Matthias eKlugmann   +8 more
doaj   +1 more source

AAV-Tis21 treatment decreases Cyclin D1 and Cyclin E and increases NeuroD1 mRNA expression levels in MB allograft tissues.

, 2018
Real-time PCR analysis of RNA obtained from the nodules treated with AAV overexpressing Tis21 (AAV-Tis21) or AAV-CBA (control). Three nodules per group were analyzed. Average ± SEM values are from (at least) three independent experiments and are shown as
Manuela Ceccarelli (4398151), Giuliana Papoff (688457), Simone Samperna (828290), Felice Tirone (256018), Simonetta Santini (828289), Laura Micheli (256012), Cristiana Lalli (687846), Lorena Zentilin (1933051), Dario Presutti (828288), Giovina Ruberti (687850)   +9 more
core   +1 more source

Gut Microbiota Regulates Systemic Inflammatory Response and Compensatory Anti‐Inflammatory Response Syndromes by Targeting PF4+ Macrophages in Acute Pancreatitis

Advanced Science, EarlyView.
ABSTRACT Acute pancreatitis (AP) begins with pancreatic local inflammation, leading to the onset of systemic inflammatory response syndrome (SIRS), followed by compensatory anti‐inflammatory response syndrome (CARS), which causes immune paralysis and higher mortality rate.
Liwei Liu, Guanqun Li, Dongxu Lu, Haoran Ding, Tianqi Lu, Yuhang Sui, Can Zhang, Yu Xie, Rui Kong, Hua Chen, Xuewei Bai, Hongtao Tan, Dongbo Xue, Xianzhi Meng, Le Li, Bei Sun   +15 more
wiley   +1 more source