Results 51 to 60 of about 89,643 (298)

Seek and destroy: targeted adeno-associated viruses for gene delivery to hepatocellular carcinoma

Drug Delivery, 2017
Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer with high incidence globally. Increasing mortality and morbidity rates combined with limited treatment options available for advanced HCC press for novel and effective ...
Bijay Dhungel, Aparna Jayachandran, Christopher J. Layton, Jason C. Steel   +3 more
doaj   +1 more source

Simultaneous visualization of extrinsic and intrinsic axon collaterals in Golgi-like detail for mouse corticothalamic and corticocortical cells: a double viral infection method

Frontiers in Neural Circuits, 2014
Here we present a novel tracing technique to stain projection neurons in Golgi-like detail by double viral infection. We used retrograde lentiviral vectors and adeno-associated viral vectors (AAV) to drive TET-ON/TET-OFF system in neurons connecting two ...
Akiya eWatakabe, Akiya eWatakabe, Masafumi eTakaji, Shigeki eKato, Kazuto eKobayashi, Hiroaki eMizukami, Keiya eOzawa, Sonoko eOhsawa, Ryosuke eMatsui, Dai eWatanabe, Tetsuo eYamamori, Tetsuo eYamamori   +11 more
doaj   +1 more source

PhP.B Enhanced Adeno-Associated Virus Mediated-Expression Following Systemic Delivery or Direct Brain Administration

Frontiers in Bioengineering and Biotechnology, 2021
Of the adeno-associated viruses (AAVs), AAV9 is known for its capability to cross the blood–brain barrier (BBB) and can, therefore, be used as a noninvasive method to target the central nervous system.
Kimberly L. Pietersz, Kimberly L. Pietersz, Francois Du Plessis, Stephan M. Pouw, Jolanda M. Liefhebber, Sander J. van Deventer, Sander J. van Deventer, Gerard J. M. Martens, Pavlina S. Konstantinova, Bas Blits   +9 more
doaj   +1 more source

Copper‐Driven Epithelial Barrier Disruption: A Novel Mechanism of COPD Acute Exacerbations Mediated by the TNF‐α/ATP7A Axis

Advanced Science, EarlyView.
This study reveals a copper‐driven mechanism of COPD acute exacerbations mediated by the TNF‐α/ATP7A axis. TNF‐α suppresses the copper transporter ATP7A via competitive NF‐κB/CREB1/CBP signaling, resulting in intracellular copper accumulation, mitochondrial oxidative stress, and epithelial barrier disruption.
Xinru Xiao, Yongzhe Hao, Ziqi Ding, Zhipeng Wang, Yujia Shi, Yanhua Huang, Chunjian Qi, Qian Zhang   +7 more
wiley   +1 more source

Altering VP1 and VP2 expression in trans affects the transduction efficiency of AAV9

Frontiers in Bioengineering and Biotechnology
Currently, adeno-associated virus (AAV) is one of the most reliable carrier for gene delivery in both proliferating and non-proliferating cells. Stable and long-lasting transgene expression has made this viral vector a key platform for the development of
Maxim K. Efremov, Alima Galieva, Andrew N. Brovin, Natalia V. Mesonzhnik, Mikhail B. Afonin, Elena N. Subcheva, Alexander Karabelsky   +6 more
doaj   +1 more source

AAV Vectors for the Nucleolus [PDF]

Molecular Therapy, 2012
During the replication of wild-type adeno-associated virus (AAV), viral capsids are assembled in the nucleolus,1 and the capsid proteins interact with the nucleolar proteins nucleolin (NCL) and nucleophosmin (NPM1), possibly promoting their transport from the cytoplasm into the nucleolus.2,3 In the case of replication-incompetent AAV vectors, the ...
openaire   +2 more sources

BAP31 Drives Cartilage Calcification through Disruption of Autophagosome–Lysosome Fusion in Osteoarthritis

Advanced Science, EarlyView.
Mechanical stress activates BAP31 in chondrocytes. BAP31 competes with ATG14 for binding to STX17, disrupting the STX17–ATG14 complex required for autophagosome–lysosome fusion. The resultant autophagic flux blockade drives the generation of autophagy‐derived exosomes, which mediate pathological cartilage calcification in OA. Chondrocyte‐targeted BAP31
Zhi‐hua Xu, Ruo‐xin Wang, Feng He, Qian Liu, Fu‐yin Li, Min Hui, Yu‐qian Shi, Yu Jiang, Qing‐hua Li, Jun‐wen Jing, Shi‐bin Yu, Li‐tian Ma, Qian‐nan Niu, Mian Zhang   +13 more
wiley   +1 more source

Intracisternal delivery of NFkappaB-inducible scAAV2/9 reveals locoregional neuroinflammation induced by systemic kainic acid treatment.

Frontiers in Molecular Neuroscience, 2014
We have previously demonstrated disease-dependent gene delivery in the brain using an AAV vector responding to NFB activation as a probe for inflammatory responses.
Olivier eBockstael, Liliane eTenenbaum, Deniz eDalkara, Catherine eMelas, Olivier eDe Witte, Marc eLevivier, Abdelwahed eChtarto   +6 more
doaj   +1 more source

Ablation of Bscl2/seipin in hepatocytes does not cause metabolic dysfunction in congenital generalised lipodystrophy

Disease Models & Mechanisms, 2020
Mutations affecting the BSCL2 gene cause the most severe form of congenital generalised lipodystrophy (CGL). Affected individuals develop severe metabolic complications including diabetes and hepatic steatosis.
George D. Mcilroy, Sharon E. Mitchell, Weiping Han, Mirela Delibegović, Justin J. Rochford   +4 more
doaj   +1 more source

AAV-expressed mAb exhibit a distinct glycosylation profile from in vitro purified or naturally secreted mAb.

, 2018
Glycans were eluted from serum anti-SIV env reactive mAbs from passively immunized or SIV-infected animals and analyzed via capillary electrophoresis.
Rosemarie D. Mason (90621), Yi Zhang (9093), Sandeep Narpala (517528), Lingshu Wang (3204129), Madeleine F. Jennewein (2564638), Cheng Cheng (68821), Galit Alter (91383), Hugh C. Welles (3174969), Alejandro B. Balazs (244312), Jeffrey D. Lifson (140183), John R. Mascola (229761), Mario Roederer (5259), John-Paul Todd (6054251), Adrian B. McDermott (635782)   +13 more
core   +1 more source