Results 51 to 60 of about 79,958 (292)

Seek and destroy: targeted adeno-associated viruses for gene delivery to hepatocellular carcinoma

Drug Delivery, 2017
Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer with high incidence globally. Increasing mortality and morbidity rates combined with limited treatment options available for advanced HCC press for novel and effective ...
Bijay Dhungel, Aparna Jayachandran, Christopher J. Layton, Jason C. Steel   +3 more
doaj   +1 more source

Simultaneous visualization of extrinsic and intrinsic axon collaterals in Golgi-like detail for mouse corticothalamic and corticocortical cells: a double viral infection method

Frontiers in Neural Circuits, 2014
Here we present a novel tracing technique to stain projection neurons in Golgi-like detail by double viral infection. We used retrograde lentiviral vectors and adeno-associated viral vectors (AAV) to drive TET-ON/TET-OFF system in neurons connecting two ...
Akiya eWatakabe, Akiya eWatakabe, Masafumi eTakaji, Shigeki eKato, Kazuto eKobayashi, Hiroaki eMizukami, Keiya eOzawa, Sonoko eOhsawa, Ryosuke eMatsui, Dai eWatanabe, Tetsuo eYamamori, Tetsuo eYamamori   +11 more
doaj   +1 more source

PhP.B Enhanced Adeno-Associated Virus Mediated-Expression Following Systemic Delivery or Direct Brain Administration

Frontiers in Bioengineering and Biotechnology, 2021
Of the adeno-associated viruses (AAVs), AAV9 is known for its capability to cross the blood–brain barrier (BBB) and can, therefore, be used as a noninvasive method to target the central nervous system.
Kimberly L. Pietersz, Kimberly L. Pietersz, Francois Du Plessis, Stephan M. Pouw, Jolanda M. Liefhebber, Sander J. van Deventer, Sander J. van Deventer, Gerard J. M. Martens, Pavlina S. Konstantinova, Bas Blits   +9 more
doaj   +1 more source

Generation of enhanced gene delivery vectors by directed evolution of adeno-associated virus [PDF]

, 2006
Despite promising advance in the development of viral vectors based on AAV for human gene therapy, several major hurdles for a more general use remain.
Endell, Jan
core  

Adipocyte‐Derived Leptolin Enhances Energy Expenditure and Prevents Obesity

Advanced Science, EarlyView.
We identified a novel adipokine, which we named leptolin. In humans, leptolin levels in white adipose tissue were positively correlated with exercise and negatively associated with body mass index. We observed elevated leptolin in serum from athletes and lower leptolin in serum from obese individuals.
Jiarui Liu, Bingwei Wang, Zhijie Su, Xiaoxv Han, Miao He, Yun Zhao, Yujia Hou, Daotong Li, Weiguang Zhang, Lihua Qin, Ke Wang, Yanchun Li, Yi Yan, Siwang Yu, Xiaoshuai Huang, Tairan Yuwen, Jianyuan Luo, Ruimao Zheng   +17 more
wiley   +1 more source

Altering VP1 and VP2 expression in trans affects the transduction efficiency of AAV9

Frontiers in Bioengineering and Biotechnology
Currently, adeno-associated virus (AAV) is one of the most reliable carrier for gene delivery in both proliferating and non-proliferating cells. Stable and long-lasting transgene expression has made this viral vector a key platform for the development of
Maxim K. Efremov, Alima Galieva, Andrew N. Brovin, Natalia V. Mesonzhnik, Mikhail B. Afonin, Elena N. Subcheva, Alexander Karabelsky   +6 more
doaj   +1 more source

AAV-expressed mAb exhibit a distinct glycosylation profile from in vitro purified or naturally secreted mAb.

, 2018
Glycans were eluted from serum anti-SIV env reactive mAbs from passively immunized or SIV-infected animals and analyzed via capillary electrophoresis.
Rosemarie D. Mason (90621), Yi Zhang (9093), Sandeep Narpala (517528), Lingshu Wang (3204129), Madeleine F. Jennewein (2564638), Cheng Cheng (68821), Galit Alter (91383), Hugh C. Welles (3174969), Alejandro B. Balazs (244312), Jeffrey D. Lifson (140183), John R. Mascola (229761), Mario Roederer (5259), John-Paul Todd (6054251), Adrian B. McDermott (635782)   +13 more
core   +1 more source

Fibronectin1‐Expressing Subicular Circuits Selectively Govern the Retrieval of Novel Object Recognition

Advanced Science, EarlyView.
Fibronectin 1 (FN1)‐expressing subicular subpopulations encode novel object preference and selectively govern retrieval of novel object recognition (NOR) via affecting excitability of entorhinal‐projecting circuit through large conductance Ca2+‐activated potassium (BK) channel. ABSTRACT Novel object recognition (NOR), referring to the cognitive ability
Fan Fei, Jiaying Shi, Jing Xi, Yixiang Xu, Shuye Ying, Xukun Fan, Wangjialu Lu, Zhisheng Li, Menghan Li, Yu Wang, Li Cheng, Lin Yang, Lingyu Xu, Zhong Chen, Cenglin Xu, Yi Wang   +15 more
wiley   +1 more source

Intracisternal delivery of NFkappaB-inducible scAAV2/9 reveals locoregional neuroinflammation induced by systemic kainic acid treatment.

Frontiers in Molecular Neuroscience, 2014
We have previously demonstrated disease-dependent gene delivery in the brain using an AAV vector responding to NFB activation as a probe for inflammatory responses.
Olivier eBockstael, Liliane eTenenbaum, Deniz eDalkara, Catherine eMelas, Olivier eDe Witte, Marc eLevivier, Abdelwahed eChtarto   +6 more
doaj   +1 more source

Ablation of Bscl2/seipin in hepatocytes does not cause metabolic dysfunction in congenital generalised lipodystrophy

Disease Models & Mechanisms, 2020
Mutations affecting the BSCL2 gene cause the most severe form of congenital generalised lipodystrophy (CGL). Affected individuals develop severe metabolic complications including diabetes and hepatic steatosis.
George D. Mcilroy, Sharon E. Mitchell, Weiping Han, Mirela Delibegović, Justin J. Rochford   +4 more
doaj   +1 more source