Results 61 to 70 of about 65,616 (261)
Molecular Therapy, 2003 One of the many hurdles that face gene therapists is the requirement to optimize gene delivery systems in such a way that both efficient and selective transgene production is achieved in vivo within a chosen cell or tissue. Exploiting native vector tropism can sometimes achieve this goal irrespective of additional modifications. For example, adenoviral
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Advanced Science, EarlyView.This study unveils an unrecognized pro‐inflammatory epitranscriptomic checkpoint in psoriasis. By installing m7G modifications on the 5′ UTR of Bdkrb1 mRNA, METTL1 enhances receptor stability to orchestrate keratinocyte‐driven neutrophil recruitment via p38 MAPK signaling.
Chang Zhang +10 more
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Advanced Science, EarlyView.A pro‐inflammatory microglial subset persists after decompression in chronic compressive cervical spinal cord injury and shows enhanced Dnmt3a‐driven m5C signaling. By stabilizing RelA mRNA, this axis sustains NF‐κB activation and postoperative neuroinflammation.
Tianyu Qin +15 more
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Evaluation of Gene Therapy as an Intervention Strategy to Treat Brain Injury from Stroke
Frontiers in Molecular Neuroscience, 2016 Stroke is a leading cause of death and disability, with a lack of treatments available to prevent cell death, regenerate damaged cells and pathways, or promote neurogenesis.
Amanda J Craig, Gary D Housley
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AAV and Insertional Mutagenesis
Molecular Therapy, 2007 In this issue of Molecular Therapy, David Russell provides an invited commentary on data presented at the tenth annual meeting of the American Society of Gene Therapy that strongly suggested that adenovirus-associated virus (AAV) vector insertion could in certain models be linked to the development of cancer.1 A short report describing the data that ...
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Advanced Science, EarlyView.In the pathological state of PD induced by MPP+, the upregulated PRMT9 in dopaminergic neurons translocates into mitochondrion and interacts with DUSP26 and catalyzes its arginine methylation, leading to the ubiquitin‐proteasomal degradation of DUSP26 mediated by Trim32.
Tengfei Liu +13 more
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Insights gained from gene therapy in animal models of retGC1 deficiency
Frontiers in Molecular Neuroscience, 2014 Vertebrate species possess two retinal guanylate cyclases (retGC1 and retGC2) and at least two guanylate cyclase activating proteins (GCAPs), GCAP1 and GCAP2. GCAPs function as Ca2+ sensors that regulate the activity of guanylate cyclases.
Shannon Elizabeth Boye
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Synergistic HMGN1 and VP64 Fusions Potentiate High‐Precision and PAM‐Flexible Base Editing
Advanced Science, EarlyView.A novel CDA1Δ‐SpRY architecture fused with HMGN1 and VP64 yields a nearly PAM‐less base editing platform. By focusing cytosine conversion predominantly at position −18, this synergistic complex ensures highly precise targeting. Demonstrating enhanced efficiency across diverse models, including yeast and rice, the platform offers a robust solution for ...
Xi Luo +11 more
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Frontiers in Neural Circuits, 2012 Recording of identified neuronal network activity using genetically encoded calcium indicators (GECIs) requires labeling that is cell type-specific and bright enough for the detection of functional signals.
Bernd eKuhn +10 more
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Annual Meeting of the Berkeley Linguistics Society, 1995 Proceedings of the Twenty-First Annual Meeting of the Berkeley Linguistics Society: General Session and Parasession on Historical Issues in Sociolinguistics/Social Issues in Historical Linguistics (1995)
Patricia Cukor-Avila, Guy Bailey
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