Results 81 to 90 of about 131,610 (332)

Dysfunctional TRIM31 of POMC Neurons Provokes Hypothalamic Injury and Peripheral Metabolic Disorder under Long‐Term Fine Particulate Matter Exposure

Advanced Science, EarlyView.
Particulate matter ≤2.5 µm (PM2.5) elevates risks of neurological and chronic metabolic diseases, but the underlying mechanisms linking PM2.5‐induced central nervous system (CNS) injury to metabolic dysfunction remain unclear. Hypothalamic pro‐opiomelanocortin‐expressing (POMC+) neurons regulate systemic metabolic homeostasis, and tripartite motif ...
Chenxu Ge, Jiamao Lin, Changsheng Yang, Chuanwang Miao, Fengxiang Li, Shuqiang Zhao, Lei Zou, Xuedong Teng, Lina Liu, Tingguang Li, Yan Sun, Qiang Li, Deshuai Lou, Linfeng Hu, Xi Liu, Gang Kuang, Jing Luo, Minxuan Xu, Minghui Chang, Jun Tan, Yanrong Ren, Bochu Wang   +21 more
wiley   +1 more source

In vivo evaluation of tropism and biodistribution of synthetic and natural adeno-associated viral vectors by next-generation sequencing

Биопрепараты: Профилактика, диагностика, лечение
INTRODUCTION. The creation of synthetic adeno-associated virus (AAV) vectors during gene therapy development is a labour-intensive and expensive process. The optimal solution to minimise the time and costs associated with gene therapy development lies in
D. O. Maksimov, D. A. Naumova, E. A. Astakhova, V. V. Artemev, S. A. Biryukov, I. S. Abramov, A. A. Navoikova, N. V. Rudev, S. G. Feoktistova, O. V. Glazova, O. N. Mityaeva, P. Yu. Volchkov   +11 more
doaj   +1 more source

Seek and destroy: targeted adeno-associated viruses for gene delivery to hepatocellular carcinoma

Drug Delivery, 2017
Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer with high incidence globally. Increasing mortality and morbidity rates combined with limited treatment options available for advanced HCC press for novel and effective ...
Bijay Dhungel, Aparna Jayachandran, Christopher J. Layton, Jason C. Steel   +3 more
doaj   +1 more source

The Reality and Measurement of the Wavefunction [PDF]

, 1993
Using a simple version of the model for the quantum measurement of a two level system, the contention of Aharonov, Anandan, and Vaidman that one must in certain circumstances give the wavefunction an ontological as well as an epistemological significance
M. Bloom, W. G. Unruh, Y. Aharonov
core   +4 more sources

Mitochondrial CISD1 Modulates Microglial Metabolic Reprogramming to Drive Stress Susceptibility in Mice

Advanced Science, EarlyView.
CDGSH iron sulfur domain 1 (CISD1) mitigates oxidative stress by promoting NADH oxidation and Coenzyme Q (CoQ) reduction. Under chronic stress, elevated CISD1 expression in microglia enhances NAD⁺ production, thereby increasing GAPDH activity and glycolytic flux, while reducing ATP synthesis by inhibiting proton transfer from mitochondrial complexes I ...
Wanting Dong, Duo Liu, Songsen Fu, Jiaming Zhang, Xi Chen, Songqiang Huang   +5 more
wiley   +1 more source

Implementation of the quality-by-design concept for an adeno-associated viral vector-based gene therapy

Биопрепараты: Профилактика, диагностика, лечение
INTRODUCTION. Currently, manufacturers of adeno-associated virus (AAV)-based gene therapy products are facing a number of systemic problems stemming from the difficulties in assessing the quality of medicinal products due to insufficient scientific data,
D. S. Kopein, G. N. Poroshin, R. A. Khamitov   +2 more
doaj   +1 more source

Cross-Packaging and Capsid Mosaic Formation in Multiplexed AAV Libraries

Molecular Therapy: Methods & Clinical Development, 2020
Generation and screening of libraries of adeno-associated virus (AAV) variants have emerged as a powerful method for identifying novel capsids for gene therapy applications.
Pauline F. Schmit, Simon Pacouret, Eric Zinn, Elizabeth Telford, Fotini Nicolaou, Frédéric Broucque, Eva Andres-Mateos, Ru Xiao, Magalie Penaud-Budloo, Mohammed Bouzelha, Nicolas Jaulin, Oumeya Adjali, Eduard Ayuso, Luk H. Vandenberghe   +13 more
doaj   +1 more source

Liver-specific knockout of arginase-1 leads to a profound phenotype similar to inducible whole body arginase-1 deficiency [PDF]

, 2016
Arginase-1 (Arg1) converts arginine to urea and ornithine in the distal step of the urea cycle in liver. We previously generated a tamoxifen-inducible Arg1 deficient mouse model (Arg1-Cre) that disrupts Arg1 expression throughout the whole body and leads
Al-Dirbashi, Osama Y., Ballantyne, Laurel L., Funk, Colin D., Hurlbut, David J., Li, Xinzhi, Sin, Yuan Yan   +5 more
core   +1 more source

Single‐Field Evolution Rule Governs the Dynamics of Representational Drift in Mouse Hippocampal Dorsal CA1 Region

Advanced Science, EarlyView.
Long‐term hippocampal place‐code dynamics are investigated using calcium imaging across weeks of maze navigation. Analyses reveal a novelty‐irrelevant Single‐Field Evolution Rule (SFER), where active fields promote persistence and inactive fields decline.
Cong Chen, Shuyang Yao, Sihui Cheng, Jiayi Tian, Ang Li, Yusen Yan, Xiang Zhang, Yuanjing Liu, Yumeng Wang, Qichen Cao, Chenglin Miao   +10 more
wiley   +1 more source

Ablation of Bscl2/seipin in hepatocytes does not cause metabolic dysfunction in congenital generalised lipodystrophy

Disease Models & Mechanisms, 2020
Mutations affecting the BSCL2 gene cause the most severe form of congenital generalised lipodystrophy (CGL). Affected individuals develop severe metabolic complications including diabetes and hepatic steatosis.
George D. Mcilroy, Sharon E. Mitchell, Weiping Han, Mirela Delibegović, Justin J. Rochford   +4 more
doaj   +1 more source