Results 1 to 10 of about 507,405 (225)

Clinically-Relevant ABC Transporter for Anti-Cancer Drug Resistance

Frontiers in Pharmacology, 2021
Multiple drug resistance (MDR), referring to the resistance of cancer cells to a broad spectrum of structurally and mechanistically unrelated drugs across membranes, severely impairs the response to chemotherapy and leads to chemotherapy failure ...
Huan Xiao, Yongcheng Zheng, Lingling Ma, Lili Tian, Qiu Sun   +4 more
doaj   +2 more sources

Genome-wide identification of ATP binding cassette (ABC) transporter and heavy metal associated (HMA) gene families in flax (Linum usitatissimum L.)

BMC Genomics, 2020
Background The recent release of the reference genome sequence assembly of flax, a self-pollinated crop with 15 chromosome pairs, into chromosome-scale pseudomolecules enables the characterization of gene families.
Nadeem Khan, Frank M. You, Raju Datla, Sridhar Ravichandran, Bosen Jia, Sylvie Cloutier   +5 more
doaj   +2 more sources

The human ATP-binding cassette (ABC) transporter superfamily

Journal of Lipid Research, 2001
The transport of specific molecules across lipid membranes is an essential function of all living organisms and a large number of specific transporters have evolved to carry out this function.
Michael Dean, Yannick Hamon, Giovanna Chimini   +2 more
doaj   +2 more sources

Genomic functional annotation and comparative analysis of ABC transporter protein family genes in nine types of Chironomidae insects [PDF]

BMC Genomics
Background The ABC (ATP-binding cassette) transporter family constitutes one of the most extensive transmembrane transporter gene families found across all realms of life. In insects, ABC transporters are crucial for processes such as nutrient metabolism,
Wenbin Liu, Anmo Zhou, Ziming Shao, Jiaxin Nie, Xinyu Ge, Chuncai Yan, Shaobo Gao, Yiwen Wang   +7 more
doaj   +2 more sources

Frequent down-regulation of ABC transporter genes in prostate cancer [PDF]

BMC Cancer, 2015
Background: ATP-binding cassette (ABC) transporters are transmembrane proteins responsible for the efflux of a wide variety of substrates, including steroid metabolites, through the cellular membranes.
Deividas Razanauskas, Feliksas Jankevicius, Juozas Rimantas Lazutka, Kristina Daniunaite, Rita Demidenko, Sonata Jarmalaite   +5 more
core   +2 more sources

Genome-wide identification and gene expression pattern of ABC transporter gene family in Capsicum spp.

PLoS ONE, 2019
ATP-binding cassette (ABC) transporter genes act as transporters for different molecules across biological membranes and are involved in a diverse range of biological processes.
Carlos Lopez-Ortiz, Sudip Kumar Dutta, Purushothaman Natarajan, Yadira Peña-Garcia, Venkata Abburi, Thangasamy Saminathan, Padma Nimmakayala, Umesh K Reddy   +7 more
doaj   +2 more sources

ABC Transporters [PDF]

FEBS Letters, 2006
ABC transporters are proteins that are involved in the uptake of nutrients and excretion of harmful substances in biological cells. Defects in human ABC transporters can result in severe diseases. Too high ABC transporter activity can lead to non-responsiveness of cancercells to chemotherapy, and resistance of bacteria to antibiotics.
Flügge, U.I., van Meer, G.
  +8 more sources

The role of ABC transporter DrrABC in the export of PDIM in Mycobacterium tuberculosis [PDF]

The Cell Surface
The Mycobacterium tuberculosis virulence lipid phthiocerol dimycocerosate (PDIM) is exported by a complex mechanism that involves multiple proteins including the Resistance-Nodulation-Division (RND) transporter MmpL7 and the lipoprotein LppX.
Nabiela Moolla, Helen Weaver, Rebeca Bailo, Albel Singh, Vassiliy N. Bavro, Apoorva Bhatt   +5 more
doaj   +2 more sources

Heliorhodopsin-mediated light-modulation of ABC transporter [PDF]

Nature Communications
Heliorhodopsins (HeRs) have been hypothesized to have widespread functions. Recently, the functions for few HeRs have been revealed; however, the hypothetical functions remain largely unknown.
Shin-Gyu Cho, Ji-Hyun Kim, Ji-eun Lee, In-Jung Choi, Myungchul Song, Kimleng Chuon, Jin-gon Shim, Kun-Wook Kang, Kwang-Hwan Jung   +8 more
doaj   +2 more sources

The human ATP‐binding cassette (ABC) transporter superfamily

Human Mutation, 2022
The ATP‐binding cassette (ABC) transporter superfamily comprises membrane proteins that efflux various substrates across extra‐ and intracellular membranes.
M. Dean, Karobi Moitra, R. Allikmets
semanticscholar   +1 more source