Results 21 to 30 of about 74,030 (255)

The human ABC transporter pseudogene family: Evidence for transcription and gene-pseudogene interference

BMC Genomics, 2008
Background Pseudogenes are an integral component of the human genome. Little attention, however, has so far been paid to the phenomenon that some pseudogenes are transcriptionally active.
Haug Kari, Kaminski Ellen, Wenzel Jürgen J, Hellum Marit, Piehler Armin P, Kierulf Peter, Kaminski Wolfgang E   +6 more
doaj   +1 more source

ABCC6 Knockdown Fuels Cell Proliferation by Regulating PPARα in Hepatocellular Carcinoma

Frontiers in Oncology, 2022
The ATP binding cassette (ABC) transporter family is ubiquitous in eukaryotes, specifically in vertebrates, and plays a crucial role in energy homeostasis, cell signaling, and drug resistance.
Zhicong Zhao, Zhicong Zhao, Zhenjun Zhao, Jianye Wang, Jianye Wang, He Zhang, He Zhang, Zhifeng Xi, Qiang Xia, Qiang Xia, Qiang Xia   +10 more
doaj   +1 more source

Characterization of bacteriocin ABC transporter ATP-binding protein produced by a newly isolated Enterococcus casseliflavus MI001 strain

Beni-Suef University Journal of Basic and Applied Sciences, 2019
Background ATP-binding cassette (ABC) transporters constitute one of the largest transporter protein families and play a role in diverse biological processes.
Indira Mikkili, Venkateswarulu TC, Abraham Peele Karlapudi, Vidya Prabhakar Kodali, Krupanidhi Srirama   +4 more
doaj   +1 more source

Binding mode analysis of ABCA7 for the prediction of novel Alzheimer's disease therapeutics

Computational and Structural Biotechnology Journal, 2021
The adenosine-triphosphate-(ATP)-binding cassette (ABC) transporter ABCA7 is a genetic risk factor for Alzheimer’s disease (AD). Defective ABCA7 promotes AD development and/or progression.
Vigneshwaran Namasivayam, Katja Stefan, Jens Pahnke, Sven Marcel Stefan   +3 more
doaj   +1 more source

Proteomic strategy for the analysis of the polychlorobiphenyl-degrading cyanobacterium Anabaena PD-1 exposed to Aroclor 1254.

PLoS ONE, 2014
The cyanobacterium Anabaena PD-1, which was originally isolated from polychlorobiphenyl (PCB)-contaminated paddy soils, has capabilities for dechlorinatin and for degrading the commercial PCB mixture Aroclor 1254.
Hangjun Zhang, Xiaojun Jiang, Wenfeng Xiao, Liping Lu   +3 more
doaj   +1 more source

ATP-BINDING CASSETTE TRANSPORTERS (ABC). NOMENCLATURE, STRUCTURE, MOLECULAR DIVERSITY, FUNCTION, CONTRIBUTION TO THE FUNCTIONING OF THE XENOBIOTICS TRANSFORMATION SYSTEM (А REWIEW)

Transactions of the Karelian Research Centre of the Russian Academy of Sciences, 2020
ATP-binding cassette (ABC) transporters are membrane proteins responsible for removing various substrates from cells through cell membranes using the energy derived from ATP hydrolysis.
Lev Smirnov
doaj   +1 more source

ATP-Binding Cassette (ABC) Transporters and Antibiotic Resistance: Specialized Systems for Capsular Polysaccharide Export in Gram-Negative Pathogens

Polysaccharides
ABC transporters are a large family of proteins that mediate the export or import of a variety of molecules, including capsular polysaccharides. The capsules are an important virulence factor that protect bacteria from host immune system attacks ...
Loreleï Masselot--Joubert, María Agostina Di Renzo   +1 more
doaj   +1 more source

Nrf2 signaling promotes cancer stemness, migration, and expression of ABC transporter genes in sorafenib-resistant hepatocellular carcinoma cells.

PLoS ONE, 2021
Background and aimAs a multiple tyrosine kinase inhibitor, sorafenib is widely used to treat hepatocellular carcinoma (HCC), but patients frequently face resistance problems.
Luping Gao, Yuji Morine, Shinichiro Yamada, Yu Saito, Tetsuya Ikemoto, Kazunori Tokuda, Chie Takasu, Katsuki Miyazaki, Mitsuo Shimada   +8 more
doaj   +1 more source

Clinically-Relevant ABC Transporter for Anti-Cancer Drug Resistance

Frontiers in Pharmacology, 2021
Multiple drug resistance (MDR), referring to the resistance of cancer cells to a broad spectrum of structurally and mechanistically unrelated drugs across membranes, severely impairs the response to chemotherapy and leads to chemotherapy failure ...
Huan Xiao, Yongcheng Zheng, Lingling Ma, Lili Tian, Qiu Sun   +4 more
doaj   +1 more source

A twist in the ABC: regulation of ABC transporter trafficking and transport by FK506‐binding proteins [PDF]

FEBS Letters, 2020
Post‐transcriptional regulation of ATP‐binding cassette (ABC) proteins has been so far shown to encompass protein phosphorylation, maturation, and ubiquitination. Yet, recent accumulating evidence implicates FK506‐binding proteins (FKBPs), a type of peptidylprolyl cis–trans isomerase (PPIase) proteins, in ABC transporter regulation. In this perspective
Markus Geisler, Tamás Hegedűs
openaire   +4 more sources