Results 21 to 30 of about 138,806 (299)

The ABCs of sterol transport

Journal of Lipid Research, 2009
Mammalian cells have developed various responses to minimize accumulation of unesterified cholesterol, as the latter can result in cell toxicity and death [reviewed in this edition by Björkhem (Björkhem, I. 2009. Are side-chain oxidized oxysterols regulators also in vivo? J. Lipid Res. In press)].
Angel, Baldán, Dragana D, Bojanic, Peter A, Edwards   +2 more
openaire   +2 more sources

Export of recombinant proteins in Escherichia coli using ABC transporter with an attached lipase ABC transporter recognition domain (LARD)

Microbial Cell Factories, 2009
Background ATP binding cassette (ABC) transporter secretes the protein through inner and outer membranes simultaneously in gram negative bacteria. Thermostable lipase (TliA) of Pseudomonas fluorescens SIK W1 is secreted through the ABC transporter.
Moon Yuseok, Kim Kyeongyeon, You Jinsun, Chung Chan, Kim Hoeon, Ahn Jung   +5 more
doaj   +1 more source

Cytochrome P450/ABC transporter inhibition simultaneously enhances ivermectin pharmacokinetics in the mammal host and pharmacodynamics in Anopheles gambiae [PDF]

, 2017
Mass administration of endectocides, drugs that kill blood-feeding arthropods, has been proposed as a complementary strategy to reduce malaria transmission.
Abizanda, Gloria, Aldaz, Azucena, Alustiza, Marta, Bilbao, José Ignacio, Castejon, Sandra, Chaccour, Carlos, Hammann, Felix, Irigoyen Barrio, Ángel, Maia, Marta F., Martí Soler, Helena, Moncada, Rafael, Pozo, José Luis Del, Tarimo, Brian B.   +12 more
core   +1 more source

Phosphorylation is required for the pathogen defense function of the Arabidopsis PEN3 ABC transporter. [PDF]

, 2017
The Arabidopsis PEN3 ABC transporter accumulates at sites of pathogen detection, where it is involved in defense against a number of pathogens. Perception of PAMPs by pattern recognition receptors initiates recruitment of PEN3 and also leads to PEN3 ...
Somerville, Shauna, Underwood, William
core   +1 more source

Karanjin interferes with ABCB1, ABCC1, and ABCG2

Journal of Pharmacy & Pharmaceutical Sciences, 2014
PURPOSE: The prominent ATP-binding cassette (ABC) transporters ABCB1, ABCC1, and ABCG2 are involved in substance transport across physiological barriers and therefore in drug absorption, distribution, and elimination.
Martin Michaelis, Florian Rothweiler, Thomas Nerreter, Mohsen Sharifi, Taravat Ghafourian, Jindrich Cinatl   +5 more
doaj   +1 more source

Genome-wide identification of ATP binding cassette (ABC) transporter and heavy metal associated (HMA) gene families in flax (Linum usitatissimum L.)

BMC Genomics, 2020
Background The recent release of the reference genome sequence assembly of flax, a self-pollinated crop with 15 chromosome pairs, into chromosome-scale pseudomolecules enables the characterization of gene families.
Nadeem Khan, Frank M. You, Raju Datla, Sridhar Ravichandran, Bosen Jia, Sylvie Cloutier   +5 more
doaj   +1 more source

Crystallization of the oligopeptide-binding protein AppA from Bacillus subtilis [PDF]

, 2004
AppA is the membrane-anchored extracellular receptor component of an ABC transporter responsible for the uptake of oligopeptides into Bacillus subtilis.
Blagova, E, Brannigan, J A, Chambers, J, Levdikov, V M, Pattenden, R J, Wilkinson, A J, Wright, L   +6 more
core   +1 more source

Relationship between conformation shift and disease related variation sites in ATP-binding cassette transporter proteins

Biophysics and Physicobiology, 2019
Transport of small molecules across the cell membrane is a crucial biological mechanism for the maintenance of the cell activity. ABC transporter family is a huge group in the transporter membrane proteins and actively transports the substrates using the
Mika Sakamoto, Hirofumi Suzuki, Kei Yura
doaj   +1 more source

ABCC6 Knockdown Fuels Cell Proliferation by Regulating PPARα in Hepatocellular Carcinoma

Frontiers in Oncology, 2022
The ATP binding cassette (ABC) transporter family is ubiquitous in eukaryotes, specifically in vertebrates, and plays a crucial role in energy homeostasis, cell signaling, and drug resistance.
Zhicong Zhao, Zhicong Zhao, Zhenjun Zhao, Jianye Wang, Jianye Wang, He Zhang, He Zhang, Zhifeng Xi, Qiang Xia, Qiang Xia, Qiang Xia   +10 more
doaj   +1 more source

The human ABC transporter pseudogene family: Evidence for transcription and gene-pseudogene interference

BMC Genomics, 2008
Background Pseudogenes are an integral component of the human genome. Little attention, however, has so far been paid to the phenomenon that some pseudogenes are transcriptionally active.
Haug Kari, Kaminski Ellen, Wenzel Jürgen J, Hellum Marit, Piehler Armin P, Kierulf Peter, Kaminski Wolfgang E   +6 more
doaj   +1 more source