Results 61 to 70 of about 507,524 (341)

Cytochrome P450/ABC transporter inhibition simultaneously enhances ivermectin pharmacokinetics in the mammal host and pharmacodynamics in Anopheles gambiae [PDF]

, 2017
Mass administration of endectocides, drugs that kill blood-feeding arthropods, has been proposed as a complementary strategy to reduce malaria transmission.
Abizanda, Gloria, Aldaz, Azucena, Alustiza, Marta, Bilbao, José Ignacio, Castejon, Sandra, Chaccour, Carlos, Hammann, Felix, Irigoyen Barrio, Ángel, Maia, Marta F., Martí Soler, Helena, Moncada, Rafael, Pozo, José Luis Del, Tarimo, Brian B.   +12 more
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Predictive role of ABC transporters in the efficacy of enfortumab vedotin for urothelial carcinoma

BJUI Compass
Objective To evaluate the correlation between ATP‐binding cassette (ABC) transporter expression and therapeutic efficacy of enfortumab vedotin (EV), an antibody‐drug conjugate targeting Nectin‐4, in urothelial cancer, as only a few studies have been ...
Toshiki Kijima, Atsuko Takada‐Owada, Hiroki Shimoda, Hidetoshi Kokubun, Toshitaka Uematsu, Kohei Takei, Hironori Betsunoh, Masahiro Yashi, Kazuyuki Ishida, Takao Kamai   +9 more
doaj   +1 more source

Genome-wide identification and evolution of ATP-binding cassette transporters in the ciliate Tetrahymena thermophila: A case of functional divergence in a multigene family

BMC Evolutionary Biology, 2010
Background In eukaryotes, ABC transporters that utilize the energy of ATP hydrolysis to expel cellular substrates into the environment are responsible for most of the efflux from cells. Many members of the superfamily of ABC transporters have been linked
Yuan Dongxia, Feng Lifang, Xiong Jie, Fu Chengjie, Miao Wei   +4 more
doaj   +1 more source

Potential application of network descriptions for understanding conformational changes and protonation states of ABC transporters. [PDF]

, 2015
The ABC (ATP Binding Cassette) transporter protein superfamily comprises a large number of ubiquitous and functionally versatile proteins conserved from archaea to humans.
Csermely, Péter, Gangal R,, Gyimesi, Gergely, Gáspár, Merse Előd, Hegedűs, Tamás, Szalay, Kristóf Zsolt   +5 more
core  

Genomic variations associated with attenuation in Mycobacterium avium subsp paratuberculosis vaccine strains [PDF]

, 2013
BACKGROUND: Mycobacterium avium subspecies paratuberculosis (MAP) whole cell vaccines have been widely used tools in the control of Johne's disease in animals despite being unable to provide complete protection. Current vaccine strains derive from stocks
Bull, TJ, Greene, M, Linedale, R, McKendrick, IJ, Sales, J, Schock, A, Sharp, JM, Stevenson, K   +7 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

An ATP-binding cassette-type cysteine transporter in Campylobacter jejuni inferred from the structure of an extracytoplasmic solute receptor protein [PDF]

, 2005
Campylobacter jejuni is a Gram-negative food-borne pathogen associated with gastroenteritis in humans as well as cases of the autoimmune disease Guillain Barre syndrome. C.
Altekruse, Anthony J. Wilkinson, Axel Müller, Brown, Bryant, Burguiere, Deka, Delaney, During-Olsen, Elena Blagova, Emsley, Fukami-Kobayashi, Gavin H. Thomas, Gouet, Harris, Holland, Hosie, Hosie, James A. Brannigan, Jones, Kaldor, Kazwala, Keith S. Wilson, Kelly, Kertesz, Kraulis, Levdikov, Magnusson, Mark J. Fogg, Martin, Merrell, Merritt, Miller, Murshudov, Newberry, Newcomer, Oh, Oh, Olsen, Palmer, Parkhill, Pawelec, Pawelec, Pei, Pei, Perrakis, Pittman, Richard Horler, Rosef, Schonheyder, Sun, Svedhem, Takahashi, Terwilliger, Vagin, Vargas, Velayudhan, Vladimir M. Levdikov, Walter, Wilkinson, Wyszynska, Yao   +61 more
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Architecture of a channel-forming O-antigen polysaccharide ABC transporter

Nature, 2017
O-antigens are cell surface polysaccharides of many Gram-negative pathogens that aid in escaping innate immune responses. A widespread O-antigen biosynthesis mechanism involves the synthesis of the lipid-anchored polymer on the cytosolic face of the ...
Y. Bi, Evan Mann, C. Whitfield, J. Zimmer   +3 more
semanticscholar   +1 more source