Results 71 to 80 of about 507,524 (341)

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Lysimachia foenum-graecum Herba Extract, a Novel Biopesticide, Inhibits ABC Transporter Genes and Mycelial Growth of Magnaporthe oryzae

The Plant Pathology Journal, 2016
To identify a novel biopesticide controlling rice blast disease caused by Magnaporthe oryzae, 700 plant extracts were evaluated for their inhibitory effects on mycelial growth of M. oryzae. The L. foenum-graecum Herba extract showed the lowest inhibition
Youngjin Lee
doaj   +1 more source

Structure of MlaFB uncovers novel mechanisms of ABC transporter regulation

eLife, 2020
ABC transporters facilitate the movement of diverse molecules across cellular membranes, but how their activity is regulated post-translationally is not well understood. Here we report the crystal structure of MlaFB from E.
Ljuvica R Kolich, Ya-Ting Chang, Nicolas Coudray, Sabrina I Giacometti, Mark R MacRae, Georgia L Isom, Evelyn M Teran, Gira Bhabha, Damian C Ekiert   +8 more
doaj   +1 more source

Natural medicinal compounds target signal transduction pathways to overcome ABC drug efflux transporter-mediated multidrug resistance in cancer.

Drug resistance updates, 2023
ATP-binding cassette (ABC) transporters such as ABCB1, ABCG2, and ABCC1 are the major players in drug efflux-mediated multidrug resistance (MDR), which severely affects the efficacy of chemotherapy. Several synthetic compounds block the drug transport by
Pradhapsingh Bharathiraja, Priya Yadav, Andaleeb Sajid, S. Ambudkar, N. Prasad   +4 more
semanticscholar   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Genome-wide identification analysis of the ATP-binding cassette transporter family and expression analysis under methyl jasmonate treatment in Panax ginseng

BMC Plant Biology
The ATP-binding cassette (ABC) transporter family is one of the largest and oldest protein families and encodes a class of transmembrane transporter proteins that transport substances in living organisms.
Mengna Liu, Jianfeng He, Gaohui He, Yu Zhang, Meiping Zhang, Yi Wang, Kangyu Wang, Mingzhu Zhao   +7 more
doaj   +1 more source

ABC Transporters in Prorocentrum lima and Their Expression Under Different Environmental Conditions Including Okadaic Acid Production

Marine Drugs, 2019
Prorocentrum lima is a typical benthic toxic dinoflagellate, which can produce phycotoxins such as okadaic acid (OA). In this study, we identified three ABC transporter genes (ABCB1, ABCC1 and ABCG2) and characterized their expression patterns, as well ...
Song Gu, Shao-Wen Xiao, Jian-Wei Zheng, Hong-Ye Li, Jie-Sheng Liu, Wei-Dong Yang   +5 more
doaj   +1 more source

Membrane Topology of the Lactococcal Bacteriocin ATP-binding Cassette Transporter Protein LcnC. Involvement of LcnC in Lactococcin A Maturation [PDF]

, 1999
Many non-lantibiotic bacteriocins of lactic acid bacteria are produced as precursors with N-terminal leader peptides different from those present in preproteins exported by the general sec-dependent (type II) secretion pathway. These bacteriocins utilize
Axelsson, Bardwell, Birnboim, Boyd, Calamia, Casadaban, Chopin, Christian M. Franke, Danielsen, Dassa, Diep, Dinh, Dower, Ehrmann, Eisenberg, Fath, Franke, Gasson, Gerard Venema, Gilmore, Higgins, Holo, Hwang, Håvarstein, Jan Kok, Jan Tiemersma, Kast, Klein, Kok, Kuipers, Kyhse-Anderson, Kyte, Laemmli, Loo, Manoil, Millan, Miller, Newton, Pearce, Prinz, Quadri, Rao, Rince, Rottlander, Sambrook, Schägger, Simon, Sipos, Stoddard, Tagg, Terzaghi, Van Belkum, Van de Guchte, Venema, Venema, Venema, Vieira, Von Heijne, Wu, Yanisch-Perron, Zhang   +60 more
core   +1 more source

ATP-Binding Cassette (ABC) Transporter Genes Involved in Pyrethroid Resistance in the Malaria Vector Anopheles sinensis: Genome-Wide Identification, Characteristics, Phylogenetics, and Expression Profile

International Journal of Molecular Sciences, 2019
background: The ATP-binding cassette (ABC) transporters family is one of the largest families of membrane proteins existing in all living organisms. Pyrethroid resistance has become the largest unique obstacle for mosquito control worldwide.
Qiyi He, Zhentian Yan, Feng-Ling Si, Yong Zhou, Wenbo Fu, Bin Chen   +5 more
semanticscholar   +1 more source

Pore Size Effects of Mesoporous N‐Doped Carbon Nanospheres as Advanced Support Material on the Activity of Molybdenum Sulfide Catalysts for the Hydrogen Evolution Reaction

Advanced Functional Materials, EarlyView.
By tuning the pore size of mesoporous N‐doped carbon (MPNC) nanospheres as support material for molybdenum sulfide, the electrochemical activity of the composite material for the hydrogen evolution reaction can be optimized. An ideal MPNC pore size of 60 nm allows a high number of molybdenum sulfide active sites while maintaining efficient proton and ...
Niklas Ortlieb, Christian Völker, Lars Guggolz, Anna Fischer   +3 more
wiley   +1 more source