Results 101 to 110 of about 6,676 (188)
Genetic Ablation of the ABC Transporter Abcc4 Impairs Lymphoid Leukemogenesis
The FASEB Journal, 2018 ABCC4 is an ABC transporter of the C sub‐family that is ubiquitously expressed and exports key endogenous compounds including cAMP and prostaglandins, and cancer chemotherapeutic drugs. cAMP and prostaglandins are signaling molecules that, among other functions, regulate thymocyte development and function.
Rebecca R. Crawford +5 more
openaire +1 more source
Matching maternal and paternal experiences underpin molecular thermal acclimation
Molecular Ecology, Volume 34, Issue 15, August 2025.Abstract The environment experienced by one generation has the potential to affect the subsequent one through non‐genetic inheritance of parental effects. Since both mothers and fathers can influence their offspring, questions arise regarding how the maternal, paternal and offspring experiences integrate into the resulting phenotype.
L. C. Bonzi +5 more
wiley +1 more source
PLoS ONE, 2016 BackgroundIn Thailand, the combined generic anti-retroviral drug stavudine/lamivudine/nevirapine (d4T/3TC/NVP) has been used to treat human immunodeficiency virus (HIV)-infected individuals since 2001.
Sirirat Likanonsakul +6 more
doaj +1 more source
Predictive clinical model of tumor response after chemoradiation in rectal cancer [PDF]
, 2017 Survival improvement in rectal cancer treated with neoadjuvant chemoradiotherapy (nCRT) is achieved only if pathological response occurs. Mandard tumor regression grade (TRG) proved to be a valid system to measure nCRT response.
Araujo, A. +9 more
core +1 more source
FEBS Open Bio, Volume 15, Issue 7, Page 1159-1175, July 2025.The A3 adenosine receptors (A3ARs) are overexpressed in prostate cancer. AR 292 and AR 357, as A3AR antagonists, are capable of blocking proliferation, modulating the expression of drug transporter genes involved in chemoresistance, ferroptosis, and the hypoxia response, and inducing cell death.
Maria Beatrice Morelli +15 more
wiley +1 more source
Natural Antioxidants as Regulators of Circular RNA Expression and Function
WIREs RNA, Volume 16, Issue 4, July/August 2025.Natural antioxidants found in food can modulate circular RNA activity, offering a novel strategy to counteract oxidative stress and its related diseases, including cardiovascular disorders, diabetes, and cancer. This emerging connection between diet and gene regulation holds promising potential for both therapy and prevention.
Aseela Fathima +6 more
wiley +1 more source
MTHFR polymorphisms in childhood acute lymphoblastic leukemia: influence on methotrexate therapy [PDF]
, 2017 Methotrexate (MTX) is an important component in the therapy used to treat childhood acute lymphoblastic leukemia ( ALL). Methylenetetrahydrofolate reductase ( MTHFR) is a key enzyme for MTX pharmacokinetics.
García-Orad Carles, África +4 more
core +4 more sources
DETERMINANTS OF ANTI-RETROVIRAL THERAPY DRUG-RELATED TOXICITIES IN HIV POSITIVE PATIENTS [PDF]
Antiretroviral therapy (ART) drugs have increasingly been shown to contribute significantly to the morbidity of HIV positive patients exposed to them. This is more so with increasing survival of HIV patients since the introduction of ART.
Danjuma, MI, Danjuma, MI
core +1 more source
Nose-to-brain delivery of antiviral drugs: A way to overcome their active efflux? [PDF]
, 2018 Although several viruses can easily infect the central nervous system (CNS), antiviral drugs often show dramatic difficulties in penetrating the brain from the bloodstream since they are substrates of active efflux transporters (AETs). These transporters,
Dalpiaz, Alessandro, Pavan, Barbara
core +2 more sources
The ABCC6 transporter : what lessons can be learnt from other ATP-binding cassette transporters? [PDF]
, 2013 ABC transporters represent a large family of ATP-driven transmembrane transporters involved in uni- or bidirectional transfer of a large variety of substrates.
De Paepe, Anne +2 more
core +2 more sources