Results 81 to 90 of about 6,676 (188)

ABCC Multidrug Transporters in Childhood Neuroblastoma: Clinical and Biological Effects Independent of Cytotoxic Drug Efflux [PDF]

, 2017
Background Although the prognostic value of the ATP-binding cassette, subfamily C (ABCC) transporters in childhood neuroblastoma is usually attributed to their role in cytotoxic drug efflux, certain observations have suggested that these multidrug ...
Ashton, Lesley J., Buxton, Allen B., Cohn, Susan L., Flemming, Claudia L., Fletcher, Jamie I., Gherardi, Samuele, Haber, Michelle, Henderson, Michelle J., Iraci, Nunzio, Kwek, Chin-Kiat, London, Wendy B., Marshall, Glenn M., Munoz, Marcia A., Murray, Jayne, Norris, Murray D., Perini, Giovanni, Porro, Antonio, Russell, Amanda J., Sartorelli, Alan C., Schwab, Manfred, Smith, Janice, Valli, Emanuele, Xue, Chengyuan   +22 more
core  

The Role of DNA Methyltransferases in Urinary System Diseases

Cancer Innovation, Volume 4, Issue 6, December 2025.
Multiple signaling pathways mediated by DNMTs in the formation of renal fibrosis: (a) DNMTs suppress the expression of transcription factor KLF4 by mediating promoter hypermethylation, thereby promoting epithelial–mesenchymal transition and contributing to the development of renal fibrosis; (b) oxidative stress can upregulate the levels of DNMTs, which
Wei Dong, Shengbin Pei, Dacheng Zhu, Cheng Zeng, Yue Qiu, Yuxin Wu, Xinlu Jia, Siqi Zhang, Chao Li, Wenjuan Zhang, Wenbing Zhang, Zhihua Chen   +11 more
wiley   +1 more source

Functional and Transcriptional Disruption of Hepatic ABC Transporters by Environmentally Relevant Short‐Chain Per‐ and Polyfluoroalkyl Substances (PFAS)

Journal of Biochemical and Molecular Toxicology, Volume 39, Issue 12, December 2025.
Low‐dose short‐chain PFAS exposures enhance hepatic ABC transporter activity and expression, revealing that environmentally relevant concentrations can reprogram xenobiotic transport pathways and potentially influence drug metabolism, bile acid handling, and lipid homeostasis, highlighting a molecular link between chronic PFAS exposure and altered ...
Gracen E. Collier, Ramon Lavado
wiley   +1 more source

A polymorphism in ABCC4 is related to efficacy of 5-FU/capecitabine-based chemotherapy in colorectal cancer patients

Scientific Reports, 2017
To investigate the association of microRNA (miRNA) binding-site polymorphisms in the drug transporter genes with the efficacy of 5-Fluorouracil (5-FU)/capecitabine-based chemotherapy in colorectal cancer (CRC), 6 polymorphisms were determined in 432 CRC ...
Qi Chen, Fanyi Meng, Lei Wang, Yong Mao, Huan Zhou, Dong Hua, Hongjian Zhang, Weipeng Wang   +7 more
doaj   +1 more source

Prmt5 is a regulator of muscle stem cell expansion in adult mice. [PDF]

, 2015
Skeletal muscle stem cells (MuSC), also called satellite cells, are indispensable for maintenance and regeneration of adult skeletal muscles. Yet, a comprehensive picture of the regulatory events controlling the fate of MuSC is missing.
Braun, Thomas, Günther, Stefan, Kim, Johnny, Krüger, Marcus, Künne, Carsten, Looso, Mario, Zhang, Ting, Zhou, Yonggang   +7 more
core  

The Concise Guide to PHARMACOLOGY 2025/26: Transporters

British Journal of Pharmacology, Volume 182, Issue S1, Page S404-S496, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Laura Amarosi, Catriona M. H. Anderson, Philip M. Beart, Stefan Broer, Paul A. Dawson, Gergely Gyimesi, Bruno Hagenbuch, James R. Hammond, Jules C. Hancox, Michal Hershfinkel, Ken‐ichi Inui, Yoshikatsu Kanai, Stephan Kemp, Edmund R. S. Kunji, Gavin Stewart, Sotiria Tavoulari, David T. Thwaites, Tiziano Verri   +28 more
wiley   +1 more source

Exercise serum regulates uric acid transporters in normal rat kidney cells

Scientific Reports, 2022
Hyperuricemia (HUA) refers to a physiological condition of high serum uric acid (SUA) level in the body, which may cause an increased risk of several chronic diseases. The kidney’s impaired uric acid (UA) metabolism is an important reason for HUA.
Zhongye Jiang, Jianmin Cao, Hao Su, Hui Cao, Zeyuan Sun, Haoze Jiang, Yanjun Fan   +6 more
doaj   +1 more source

Association of Pharmacogenetic Markers with Premature Discontinuation of First-line Anti-HIV Therapy: An Observational Cohort Study [PDF]

, 2017
Background. Poor tolerance and adverse drug reactions are main reasons for discontinuation of antiretroviral therapy (ART). Identifying predictors of ART discontinuation is a priority in HIV care. Methods.
Bernasconi, Enos, Cavassini, Matthias, Colombo, Sara, di Iulio, Julia, Elzi, Luigia, Furrer, Hansjakob, Günthard, Huldrych F., Hirschel, Bernard, Ledergerber, Bruno, Lubomirov, Rubin, Martinez, Raquel, Telenti, Amalio, Vernazza, Pietro   +12 more
core  

Measurement and clinical significance of biomarkers of oxidative stress in humans [PDF]

, 2017
Oxidative stress is the result of the imbalance between reactive oxygen species (ROS) formation and enzymatic and nonenzymatic antioxidants. Biomarkers of oxidative stress are relevant in the evaluation of the disease status and of the health-enhancing ...
Altieri, Fabio, Marrocco, Ilaria, Peluso, Ilaria   +2 more
core   +3 more sources

The FoxM1-ABCC4 axis mediates carboplatin resistance in human retinoblastoma Y-79 cells [PDF]

Acta Biochimica et Biophysica Sinica, 2018
Carboplatin is the most commonly used drug in the first-line treatment of human retinoblastoma (RB), but its clinical application is greatly limited due to acquired drug resistance upon the long-term treatment. Forkhead box protein M1 (FoxM1) is the transcription factor aberrantly expressed in various types of human cancers, which plays an essential ...
Xue, Zhu, Lidan, Xue, Yong, Yao, Ke, Wang, Chengye, Tan, Miao, Zhuang, Fanfan, Zhou, Ling, Zhu   +7 more
openaire   +2 more sources