Results 161 to 170 of about 3,078 (183)
Effect of Quercetin on ABCC6 Transporter: Implication in HepG2 Migration [PDF]
International Journal of Molecular Sciences, 2021 Quercetin is a member of the flavonoid group of compounds, which is abundantly present in various dietary sources. It has excellent antioxidant properties and anti-inflammatory activity and is very effective as an anti-cancer agent against various types of tumors, both in vivo and in vitro.
Angela Ostuni +2 more
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Analysis of ABCC6 (MRP6) in normal human tissues
Histochemistry and Cell Biology, 2005To determine the tissue distribution of the ABC transporter ABCC6 in normal human tissues, we analyzed tissue arrays for the presence of ABCC6 mRNA by in situ hybridization and ABCC6 protein by immunohistochemistry using the polyclonal antibody HB-6. We detected ABCC6 mRNA and protein in various epithelial cells of exocrine and endocrine tissues, such ...
Charles D Boyd
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Journal of Histochemistry and Cytochemistry, 2003 We have studied the tissue distribution of Abcc6, a member of the ABC transmembrane transporter subfamily C, in normal C57BL/6 mice. RNase protection assays revealed that although almost all tissues studied contained detectable levels of the mRNA ...
Olivier le Saux +2 more
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Mutations in ABCC6 cause pseudoxanthoma elasticum
Nature Genetics, 2000Pseudoxanthoma elasticum (PXE) is a heritable disorder of the connective tissue. PXE patients frequently experience visual field loss and skin lesions, and occasionally cardiovascular complications. Histopathological findings reveal calcification of the elastic fibres and abnormalities of the collagen fibrils.
Bergen, A. A. +11 more
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Efficient Molecular Diagnostic Strategy for ABCC6 in Pseudoxanthoma Elasticum
Genetic Testing, 2004Pseudoxanthoma elasticum (PXE) is a hereditary disorder of connective tissue with skin, cardiovascular, and visual involvement. In familial cases, PXE usually segregates in an autosomal recessive fashion. The aim of this manuscript is to describe an efficient strategy for DNA diagnosis of PXE.
Hu, Xiaofeng +7 more
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Journal of Molecular Histology, 2005
Mutations in the gene coding for the ABC transporter, ABCC6, in humans cause Pseudoxanthoma elasticum, which is characterized by the deposition of aberrant elastic fibers. To investigate whether the presence of ABCC6 in tissues synthesizing elastin is required for elastin deposition and elastic fiber assembly, we have compared the steady-state levels ...
Konstanze, Beck +2 more
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Mutations in the gene coding for the ABC transporter, ABCC6, in humans cause Pseudoxanthoma elasticum, which is characterized by the deposition of aberrant elastic fibers. To investigate whether the presence of ABCC6 in tissues synthesizing elastin is required for elastin deposition and elastic fiber assembly, we have compared the steady-state levels ...
Konstanze, Beck +2 more
openaire +2 more sources
[From gene to disease; pseudoxanthoma elasticum and the ABCC6 gene].
Nederlands tijdschrift voor geneeskunde, 2004Pseudoxanthoma elasticum (PXE) is a hereditary disease of the connective tissue characterized by progressive dystrophic mineralization of elastic fibres. PXE patients have skin lesions, may experience loss of visual acuity and cardiovascular complications. The inheritance pattern of PXE is almost always autosomal recessive.
Bergen, A.A.B +3 more
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Disruption of Abcc6 Transporter in Zebrafish Causes Ocular Calcification and Cardiac Fibrosis
International Journal of Molecular Sciences, 2021Tao Zhong, Jianjian Sun
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