Results 11 to 20 of about 4,476 (134)

Novel <i>ABCG5</i> and <i>ABCG8</i> Variants in Sitosterolemia: Insights Into Haemolysis, Calcium Dysregulation and Therapeutic Challenges. [PDF]

Hum Mutat
Sitosterolemia is a rare autosomal recessive lipid metabolic disorder caused by mutations in ABCG5 or ABCG8, leading to pathological accumulation of dietary plant sterols. The condition is clinically heterogeneous, presenting with xanthomas, premature atherosclerosis and haematological abnormalities such as stomatocytosis, haemolytic anaemia and ...
Warang P, Dongerdiye R, Dehadrai P, Kamble P, Samanpalliwar N, Madkaikar M, Shanmukhaiah C, Kedar PS.   +7 more
europepmc   +2 more sources

Maternal Chrono-Nutrition and Placental DNA Methylation: The BiSC Study. [PDF]

Mol Nutr Food Res
This is the first study to examine how the timing of a mother's meals during pregnancy relates to changes in placental DNA methylation, an epigenetic mark. We found that the timing of the last daily meal was most important. Some epigenetic changes were linked to genes involved in placental function and development, and the long‐term health consequences
Llauradó-Pont J, Aguilar-Lacasaña S, Cosin-Tomas M, Julvez J, Contreras-Rodríguez O, Kogevinas M, Papantoniou K, Gallo E, Harding BN, Vrijheid M, Dadvand P, Bustamante M, Lassale C.   +12 more
europepmc   +2 more sources

Beneficial effect of ezetimibe-atorvastatin combination therapy in patients with a mutation in ABCG5 or ABCG8 gene

Lipids in Health and Disease, 2020
Background Use of ezetimibe on top of statin therapy has been shown to be effective to reduce LDL cholesterol level in hypercholesterolemic patients. However, little is known regarding the individual variety of the effectiveness of ezetimibe.
Hayato Tada, Hirofumi Okada, Akihiro Nomura, Masayuki Takamura, Masa-aki Kawashiri   +4 more
doaj   +1 more source

The effects of ABCG5/G8 polymorphisms on plasma HDL cholesterol concentrations depend on smoking habit in the Boston Puerto Rican Health Study*[S]

Journal of Lipid Research, 2009
Low HDL-cholesterol (HDL-C) is associated with an increased risk for atherosclerosis, and concentrations are modulated by genetic factors and environmental factors such as smoking.
Mireia Junyent, Katherine L. Tucker, Caren E. Smith, Antonio Garcia-Rios, Josiemer Mattei, Chao-Qiang Lai, Laurence D. Parnell, Jose M. Ordovas   +7 more
doaj   +1 more source

An ATP-Binding Cassette Pleiotropic Drug Transporter Protein Is Required for Xenobiotic Tolerance and Antagonism in the Fungal Biocontrol Agent Clonostachys rosea

Molecular Plant-Microbe Interactions, 2014
ATP-binding cassette (ABC) transporters mediate active efflux of natural and synthetic toxicants and are considered to be important for drug tolerance in microorganisms.
Mukesh K. Dubey, Dan Funck Jensen, Magnus Karlsson   +2 more
doaj   +1 more source

The missense mutation in Abcg5 gene in spontaneously hypertensive rats (SHR) segregates with phytosterolemia but not hypertension

BMC Genetics, 2005
Background Sitosterolemia is a recessively inherited disorder in humans that is associated with premature atherosclerotic disease. Mutations in ABCG5 or ABCG8, comprising the sitosterolemia locus, STSL, are now known to cause this disease.
Tso Patrick, Yu Hongwei, Ullian Michael E, Fitzgibbon Wayne R, Zheng Shuqin, Batta Ashok, Chen Jianliang, Salen Gerald, Patel Shailendra B   +8 more
doaj   +1 more source

Plant sterol hyperabsorption caused by uncontrolled diabetes in a patient with a heterozygous ABCG5 variant

Journal of Diabetes Investigation, 2022
Plant sterol intake is widely recommended for patients with cardiovascular risk factors based on the inhibitory effect on intestinal cholesterol absorption.
Masashi Hasebe, Yorihiro Iwasaki, Yamato Keidai, Kanako Iwasaki, Sachiko Honjo, Akihiro Hamasaki   +5 more
doaj   +1 more source

The rat STSL locus: characterization, chromosomal assignment, and genetic variations in sitosterolemic hypertensive rats

BMC Cardiovascular Disorders, 2003
Background Elevated plant sterol accumulation has been reported in the spontaneously hypertensive rat (SHR), the stroke-prone spontaneously hypertensive rat (SHRSP) and the Wistar-Kyoto (WKY) rat.
Klein Richard, Sato Masao, Egashira Nami, Ikeda Ikuo, Helou Khalil, Lu Kangmo, Lee Mi-Hye, Klett Eric, Pandit Bhaswati, Yu Hongwei, Batta Ashok, Salen Gerald, Patel Shailendra B   +12 more
doaj   +1 more source

Effects of High-Intensity Resistance Training and Aerobic Exercise on Expression of ABCG4, ABCG5 and ABCG8 Genes in Female Athletes

Medical Laboratory Journal, 2020
Background and objectives: Atherosclerotic cardiovascular disease is the leading cause of death in industrialized countries. High level of plasma lipids including cholesterol and triglycerides is one of the most important risk factors of atherosclerosis.
Reza Bagheri, Samane Darroudi, S Mojtaba Hosseini, Hossein Nikkar, fatemeh khodadadi, somayye kasraee, Mahbube sazegar, Amir Rashidlamir   +7 more
doaj  

اثر هشت هفته تمرین هوازی بر بیان ژن ABCG5 مونوسیت‌ها در مردان میان‌سال پس از عمل بای‌پس قلبی [PDF]

مجله دانشگاه علوم پزشکی سبزوار, 2017
اهدافبازتوانی قلبی از مهم‌ترین اقدامات جهت اثربخشی عمل جراحی قلب و کاهش عوارض آن در بیماران قلبی- عروقی است. تمرینات ورزشی به سبب کم‌هزینه و جذاب بودن مشوقی برای شرکت بیماران در این برنامه‌هاست. فعالیت ورزشی روی ترکیبات سلول خونی، به‌ویژه تعداد گلبول‌های
رامبد خواجه ای, امیر حسین حقیقی, محمدرضا حامدی نیا, امیر رشیدلمیر   +3 more
doaj