Results 51 to 60 of about 4,476 (134)

Endotoxin down-regulates ABCG5 and ABCG8 in mouse liver and ABCA1 and ABCG1 in J774 murine macrophages

Journal of Lipid Research, 2003
Several of the ATP binding cassette (ABC) transporters have recently been shown to play important roles in reverse cholesterol transport (RCT) and prevention of atherosclerosis.
Weerapan Khovidhunkit, Arthur H. Moser, Judy K. Shigenaga, Carl Grunfeld, Kenneth R. Feingold   +4 more
doaj   +1 more source

Cordyceps sinensis (CS) Alleviates Chronic Obstructive Pulmonary Disease Symptoms (COPD) by Targeting Inflammation, Apoptosis, and Oxidative Stress Through Ingredient–Gene–Disease Interaction

Immunity, Inflammation and Disease, Volume 13, Issue 12, December 2025.
Our findings indicate that Cordyceps Sinensis (CS) alleviates COPD symptoms by inhibiting inflammation and oxidative stress, with key biomarkers such as interleukins (ILs), tumor necrosis factor (TNF), and reactive oxygen species (ROS) identified. Activating autophagy serves as a protective mechanism against COPD development induced by oxidative stress.
Zirui Zang, Yuhan Kong, Qi Kong
wiley   +1 more source

Dietary xenosterols lead to infertility and loss of abdominal adipose tissue in sterolin-deficient mice[S]

Journal of Lipid Research, 2013
The investigation of the human disease sitosterolemia (MIM 210250) has shed light not only on the pathways by which dietary sterols may traffic but also on how the mammalian body rids itself of cholesterol and defends against xenosterols.
Curzio Solca, G. Stephen Tint, Shailendra B. Patel   +2 more
doaj   +1 more source

A mouse model of sitosterolemia: absence of Abcg8/sterolin-2 results in failure to secrete biliary cholesterol

BMC Medicine, 2004
Background Mutations in either of two genes comprising the STSL locus, ATP-binding cassette (ABC)-transporters ABCG5 (encoding sterolin-1) and ABCG8 (encoding sterolin-2), result in sitosterolemia, a rare autosomal recessive disorder of sterol ...
Oude-Elferink Ronald, Looije Norbert, Klein Richard, Chen Jianliang, Yu Hongwei, Batta Ashok K, Shefer Sarah, Altenburg Michael, Lee Mi-Hye, Vink Edwin, Kosters Astrid, Lu Kangmo, Klett Eric L, Groen Albert K, Maeda Nobuyo, Salen Gerald, Patel Shailendra B   +16 more
doaj   +1 more source

Effect of physical activity on prevention and treatment of atherosclerosis: focus on activity of ABCG5 and ABCG8 genes

مجله دانشگاه علوم پزشکی گرگان, 2019
Atherosclerosis which is the result of cholesterol deposit in coronary arteries is the main cause of morbidity and mortality, worldwide. Reverse cholesterol transport (RCT) is a process that causes efflux of excess cholesterol in vessels layers and ...
Mohsen Jafari
doaj  

ABCG5/G8 polymorphisms and markers of cholesterol metabolism: systematic review and meta-analysis[S]

Journal of Lipid Research, 2010
Genetic variation at the ABCG5/G8 locus has been associated with markers of cholesterol homeostasis. As data originate from small-scale studies, we performed a meta-analysis to study these associations in a large dataset.
Lily Jakulj, Maud N. Vissers, Michael W.T. Tanck, Barbara A. Hutten, Frans Stellaard, John J.P. Kastelein, Geesje M. Dallinga-Thie   +6 more
doaj   +1 more source

FXR activation promotes intestinal cholesterol excretion and attenuates hyperlipidemia in SR‐B1‐deficient mice fed a high‐fat and high‐cholesterol diet

Physiological Reports, 2020
Obeticholic acid (OCA) activates the farnesoid X receptor (FXR) to lower circulating total cholesterol (TC) and high density lipoprotein‐cholesterol (HDL‐C) concentrations and to stimulate fecal cholesterol excretion in mice by increasing hepatic SR‐B1 ...
Amar B. Singh, Bin Dong, Fredric B. Kraemer, Jingwen Liu   +3 more
doaj   +1 more source

Polymorphisms in the ABCG5 and ABCG8 genes associate with cholesterol absorption and insulin sensitivity

Journal of Lipid Research, 2004
The roles of polymorphisms of the sitosterolemia genes ABCG5 and ABCG8 in the regulation of cholesterol metabolism and insulin sensitivity were studied in mildly hypercholesterolemic noncoronary subjects (n = 263, 144 men and 119 women) divided into ...
Helena Gylling, Maarit Hallikainen, Jussi Pihlajamäki, Jyrki Ågren, Markku Laakso, Radhakrishnan A. Rajaratnam, Rainer Rauramaa, Tatu A. Miettinen   +7 more
doaj   +1 more source

Gene variants and clinical characteristics of children with sitosterolemia

Lipids in Health and Disease
Objective To enhance the detection, management and monitoring of Chinese children afflicted with sitosterolemia by examining the physical characteristics and genetic makeup of pediatric patients.
Rui Gu, Hui Wang, Chun-Lin Wang, Mei Lu, Miao Miao, Meng-Na Huang, Yi Chen, Yang-Li Dai, Ming-Qiang Zhu, Qiong Zhou, Chao-Chun Zou   +10 more
doaj   +1 more source

Selective sterol accumulation in ABCG5/ABCG8-deficient mice

Journal of Lipid Research, 2004
The ATP binding cassette (ABC) transporters ABCG5 and ABCG8 limit intestinal absorption and promote biliary secretion of neutral sterols. Mutations in either gene cause sitosterolemia, a rare recessive disease in which plasma and tissue levels of several
Liqing Yu, Klaus von Bergmann, Dieter Lutjohann, Helen H. Hobbs, Jonathan C. Cohen   +4 more
doaj   +1 more source