Results 121 to 130 of about 514,785 (377)

Microlenses immersed in nematic liquid crystal with electrically controllable focal length [PDF]

open access: yes, 1995
A microlens immersed in a nematic liquid crystal cell has been constructed with avariable focal length which can be controlled by applying an analogue voltage to thenematic liquid crystal. The focal length is -910 ± 30 ?
Chia, CH   +3 more
core  

Coronagraphic Low Order Wave Front Sensor : post-processing sensitivity enhancer for high performance coronagraphs

open access: yes, 2011
Detection and characterization of exoplanets by direct imaging requires a coronagraph designed to deliver high contrast at small angular separation. To achieve this, an accurate control of low order aberrations, such as pointing and focus errors, is ...
Beuzit J.   +8 more
core   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

Chronic migraine and optical higher-order aberrations: Is there a relationship between them?

open access: yesDelta Journal of Ophthalmology, 2019
Introduction Migraine is a neurological disorder with a wide spectrum of manifestations, including ocular manifestations. The present study aimed to investigate the relationship between chronic migraine and optical higher-order aberrations.
Ahmed A Alhagaa
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

Clinical Outcomes of a Monofocal, Optimized, Aspheric, Hydrophobic Acrylic Intraocular Lens Implant

open access: yesClinical Ophthalmology, 2023
Berta García-Tomás, José María Marín-Sánchez, Christian García-Elskamp, Encarnación Alcon-Ruiz, Laura Montesinos-López, Beatriz García Martínez-Lozano Cataract and Refractive Surgery Department, Murcia, 30009, SpainCorrespondence: Berta García-Tomás ...
García-Tomás B   +5 more
doaj  

Correction of Optical Aberrations in Elliptic Neutron Guides

open access: yes, 2012
Modern, nonlinear ballistic neutron guides are an attractive concept in neutron beam delivery and instrumentation, because they offer increased performance over straight or linearly tapered guides.
Andersen, Ken H.   +4 more
core   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

open access: yesMolecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts   +8 more
wiley   +1 more source

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