Results 41 to 50 of about 365 (96)

Testing toxicity of ABHD16A inhibiting compounds using mice cortical neurons

, 2023
Alfa-beeta-hydrolyysidomeenin (ABHD) sisältävät proteiinit osallistuvat lipidiaineenvaihduntaan ja sen säätelyyn ihmis- ja eläinsoluissa. Näitä proteiineja on tunnistettu noin 50 ja niiden fysiologisia sekä patofysiologisia toimintoja tutkitaan edelleen.
Viinamäki, Emilia
core  

Positive correlations of miRNA-mRNA (a–b) and miRNA-miRNA (c) pairs in platelet concentrates (PCs) treated with different pathogen reduction systems and the control.

, 2015
Correlations are shown between miR-484 and ABHD16A (a), miR-24 and ABHD16A (b) and between miR-24 and miR-484 (c). On the x-axis, the relative expression of each miRNA is shown, whereas the normalized expression of mRNA is shown on the y-axis: mRNA ...
Abdimajid Osman (495669), Walter E. Hitzler (769732), Patrick Provost (21115), Adam Ameur (275274)   +3 more
core   +1 more source

The effect of SAHA on the expression of genes in wild type and Hdac2 knockout mouse models and its potential use as treatment for schizophrenia [PDF]

, 2017
The symptoms of schizophrenia have been categorized into three subsets including positive, negative, and cognitive symptoms. Although atypical antipsychotic use has shown promising reduction in positive and negative symptoms of schizophrenia, such as ...
Ijaz, Maryum K
core   +1 more source

Discovery of novel inhibitors to investigate diacylglycerol lipases and α/β hydrolase domain 16A [PDF]

, 2016
  This Thesis reports on the discovery and optimization of potent inhibitors for the serine hydrolases sn-1 diacylglycerol lipase α (DAGLα) and α/β hydrolase domain 16A (ABHD16A).
Janssen, F.J.
core  

Synthesis of Chemical Probes for Studying Neuroinflammatory and Chronic Pain Conditions

, 2023
Long-lasting pain is often defined as chronic pain, which does not have any beneficial biological purpose. Chronic pain conditions are widely treated with opioid analgesics, albeit they induce severe adverse effects, such as dependence.
Ahonen, Tiina
core  

The Endocannabinoid Metabolite Prostaglandin E2 (PGE2)-Glycerol Inhibits Human Neutrophil Functions: Involvement of Its Hydrolysis into PGE2 and EP Receptors

, 2017
The endocannabinoids 2-arachidonoyl-glycerol and N-arachidonoyl-ethanolamine mediate an array of pro- and anti-inflammatory effects. These effects are related, in part, to their metabolism by eicosanoid biosynthetic enzymes.
Michel Laviolette, Stéphanie Jean, Cyril Martin, Marie-Renée Blanchet, Caroline Turcotte, David Marsolais, Nicolas Flamand, Simona Zarini, Robert C. Murphy   +8 more
core   +1 more source

Identification and association analysis of several hundred single nucleotide polymorphisms within candidate genes for back fat thickness in Italian Large White pigs using a selective genotyping approach.

, 2012
Combining different approaches (resequencing of portions of 54 obesity candidate genes, literature mining for pig markers associated with fat deposition or related traits in 77 genes, and in silico mining of porcine expressed sequence tags and other ...
RUSSO, VINCENZO, CALO', DANIELA GIOVANNA, SCHIAVO, GIUSEPPINA, FONTANESI, LUCA, CASADIO, RITA, SCOTTI, EMILIO, Buttazzoni L, FRONZA, RAFFAELE, MARTELLI, PIER LUIGI, COLOMBO, MICHELA, GALIMBERTI, GIULIANO   +10 more
core   +1 more source

Human leukocytes differentially express endocannabinoid-glycerol lipases and hydrolyze 2-arachidonoyl-glycerol and its metabolites from the 15-lipoxygenase and cyclooxygenase pathways

, 2019
2-Arachidonoyl-glycerol (2-AG) is an endocannabinoid with anti-inflammatory properties. Blocking 2-AG hydrolysis to enhance CB2 signaling has proven effective in mouse models of inflammation.
Flamand, Nicolas, Martin, Cyril, Archambault, Anne-Sophie, Di Marzo, Vincenzo, Dumais, Élizabeth, Blanchet, Marie-Renée, Boulet, Louis-Philippe, Turcotte, Caroline, Bissonnette, Elyse, Laviolette, Michel   +9 more
core   +1 more source

Microglia extract neuronal proteolytic organelles via skoupocytosis

Neurons face unique challenges in maintaining protein homeostasis due to their tortuous morphology and extended processes. Proteolytic organelles are typically transported retrogradely towards their soma for degradation where lysosomes are enriched, but ...
JoAnn Buchanan, Renee Pepper, Frances Middleton-Davis, Lani Tran, Jacqueline M Griswold, Sarah Syed, Yu Kang T Xu, Shigeki Watanabe, Yuuta Imoto, Dwight E Bergles   +9 more
core   +1 more source

Discovery and Characterization of IFITM S-Palmitoylation. [PDF]

Viruses, 2023
Das T, Hang HC.
europepmc   +1 more source