Results 31 to 40 of about 365 (96)

Interferon inducible transmembrane protein 3 (IFITM3) inhibits influenza virus replication and inflammation by interacting with ABHD16A [PDF]

, 2020
IFITM family proteins have broad-spectrum antiviral capabilities. Preliminary studies in our laboratory have preliminarily proved that IFITMs have the effect of inhibiting influenza viruses. In order to further study its mechanism and role in the occurrence and development of influenza, relevant studies have been carried out.
Chen Liang, Zhu Limei, Chen Jun
openaire   +1 more source

The loss of enzymatic activity of the PHARC‐associated lipase ABHD12 results in increased phagocytosis that causes neuroinflammation

European Journal of Neuroscience, Volume 54, Issue 10, Page 7442-7457, November 2021., 2021
In mammals, the lipase ABHD12, mutations of which cause the human neurological disorder PHARC, metabolizes immunomodulatory lyso‐PS and pro‐apoptotic oxidized PS lipids. Here, with the use of the murine model of PHARC and cellular systems, we show, that upon an inflammatory stimulus, loss of ABHD12 activity results in heightened microglial phagocytosis
Shubham Singh, Siddhesh S. Kamat
wiley   +1 more source

Clinical utility of a genetic diagnosis in individuals with cerebral palsy and related motor disorders. [PDF]

Ann Clin Transl Neurol
Abstract Objective Evaluation of the clinical utility of a genetic diagnosis in CP remains limited. We aimed to characterize the clinical utility of a genetic diagnosis by exome sequencing (ES) in patients with CP and related motor disorders. Methods We enrolled participants with CP and “CP masquerading” conditions in an institutional ES initiative. In
Santana Almansa A, Gable DL, Frazier Z, Sveden A, Quinlan A, Chopra M, Lewis SA, Kruer M, Poduri A, Srivastava S.   +9 more
europepmc   +2 more sources

Ligand‐Controlled Palladium‐Catalyzed Carbonylation of Alkynols: Highly Selective Synthesis of α‐Methylene‐β‐Lactones

Angewandte Chemie, Volume 132, Issue 48, Page 21769-21774, November 23, 2020., 2020
The advanced Pd/L11 system enables highly regioselective carbonylation of alkynols for synthesis of a wide range of 4‐membered α‐methylene‐β‐lactones. Abstract The first general and regioselective Pd‐catalyzed cyclocarbonylation to give α‐methylene‐β‐lactones is reported. Key to the success for this process is the use of a specific sterically demanding
Yao Ge, Fei Ye, Jiawang Liu, Ji Yang, Anke Spannenberg, Haijun Jiao, Ralf Jackstell, Matthias Beller   +7 more
wiley   +2 more sources

Interferon Inducible Transmembrane Protein 3 Inhibits Influenza Virus Replication and Inflammation by Interacting With ABHD16A

, 2020
Abstract Background: Studies have shown that human interferon inducible transmembrane proteins (IFITM) family proteins have broad-spectrum antiviral capabilities. Preliminary studies in our laboratory have preliminarily proved that IFITMs have the effect of inhibiting influenza viruses.
Chen Liang, Limei Zhu, Jun Chen
openaire   +1 more source

Interferon‐induced transmembrane (IFITM) proteins at the tumour–immune interface: A four‐axis framework for their context‐dependent roles

Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.
Interferon‐induced transmembrane (IFITM) function in cancer is set by four contextual coordinates, not by family membership. Acute interferon input drives major histocompatibility complex class I (MHC‐I)‐linked immunogenicity; chronic input drives programmed death‐ligand 1 (PD‐L1)‐coupled resistance.
Zhe Liu, Jie Meng, Zengyan Lai, Fuqiu Li, Sha Lv   +4 more
wiley   +1 more source

Beyond PD‐1/PD‐L1: New Immune Checkpoints and Therapeutic Combinations in Cancer Immunotherapy

Medicine Bulletin, Volume 2, Issue 1, Page 61-93, January 2026.
ABSTRACT Recently, immune checkpoint inhibitors (ICIs), particularly PD‐1/PD‐L1 and CTLA‐4 inhibitors, have revolutionized cancer treatment, significantly improving survival rates for various malignancies. However, ICI therapies targeting single checkpoints on T cells still face numerous challenges, such as low response rates and post‐treatment ...
Yangyang Li, Zizhen Kang, Yanyun Du
wiley   +1 more source

Bridging viral hepatitis and liver cancer: Emerging concepts in pathogenesis and therapeutic innovation

Clinical and Translational Discovery, Volume 5, Issue 3, June 2025.
This review elucidates distinct (hepatitis B virus [HBV] DNA integration, oncoproteins; hepatitis C virus [HCV] metabolic dysregulation, fibrosis) and shared (chronic inflammation, epigenetic alterations, genomic instability) molecular mechanisms driving viral hepatitis (HBV/HCV)‐induced hepatocellular carcinoma.
Keyin Zheng, Aimin Jiang, Zhengrui Li, Li Chen, Kailai Li, Junyi Shen, Hank Z. H. Wong, Quan Cheng, Jian Zhang, Anqi Lin, Peng Luo   +10 more
wiley   +1 more source

A Novel Compound Heterozygous Variant in the ABHD12 Gene Cause PHARC Syndrome in a Chinese Family: The Proband Presenting New Genotype and Phenotype

Molecular Genetics &Genomic Medicine, Volume 13, Issue 2, February 2025.
The principal symptoms of the proband comprised profound sensorineural hearing loss since childhood, severe visual impairment, congenital cataracts, cone‐rod dystrophy, and ataxia. Whole Exome Sequencing (WES) revealed that the proband carried a compound heterozygous variant in the ABHD12 gene: M1, a known nonsense variation c.477G>A (p.Trp159Ter); and
Meijiao Ma, Jinhai Ma, Yuanyuan Lian, Xueli Wu, Wenming Wang, Weining Rong, Xunlun Sheng   +6 more
wiley   +1 more source

S‐acylation: an orchestrator of the life cycle and function of membrane proteins

The FEBS Journal, Volume 291, Issue 1, Page 45-56, January 2024.
In this viewpoint, we propose that S‐acylation, that is, the reversible post‐translational modification of proteins with fatty acids, impacts two critical cellular processes: the biogenesis of membrane proteins, where S‐acylation of cytosolic domains may protect from premature ER‐associated degradation, facilitating folding and traffic; and the ...
Francisco S. Mesquita, Laurence Abrami, Arthur Samurkas, F. Gisou van der Goot   +3 more
wiley   +1 more source