An ER phospholipid hydrolase drives ER-associated mitochondrial constriction for fission and fusion [PDF]
eLife, 2022 Mitochondria are dynamic organelles that undergo cycles of fission and fusion at a unified platform defined by endoplasmic reticulum (ER)-mitochondria membrane contact sites (MCSs). These MCSs or nodes co-localize fission and fusion machinery. We set out
Tricia T Nguyen, Gia K Voeltz
doaj +3 more sources
Immunomodulatory lysophosphatidylserines are regulated by ABHD16A and ABHD12 interplay [PDF]
Nature Chemical Biology, 2015 Lysophosphatidylserines (lyso-PSs) are a class of signaling lipids that regulate immunological and neurological processes. The metabolism of lyso-PSs remains poorly understood in vivo. Recently, we determined that ABHD12 is a major brain lyso-PS lipase, implicating lyso-PSs in the neurological disease polyneuropathy, hearing loss, ataxia, retinitis ...
Benjamin Cravatt +2 more
exaly +4 more sources
Mirtronic miR-4646-5p promotes gastric cancer metastasis by regulating ABHD16A and metabolite lysophosphatidylserines [PDF]
Cell Death and Differentiation, 2021 AbstractThe aberrant classical miRNAs are considered to play significant roles in tumor progression. However, it remains unclear for nonclassical miRNAs, a set of Drosha-independent miRNAs in the process of various biology. Here, we reveal that a nonclassical miR-4646-5p plays a pivotal role in gastric cancer (GC) metastasis. MiR-4646-5p, one of Drosha-
Manran Liu, Yixuan Hou, Fanlin Zhou
exaly +5 more sources
Retracted: Human Interferon Inducible Transmembrane Protein 3 (IFITM3) Inhibits Influenza Virus A Replication and Inflammation by Interacting with ABHD16A. [PDF]
Biomed Res Int, 2022 BioMed Research International, Volume 2022, Issue 1, 2022.
International BR.
europepmc +3 more sources
Investigation of susceptibility genes for chickenpox disease across multiple continents [PDF]
Biochemistry and Biophysics Reports, 2023 Chickenpox (varicella) is caused by infection with the varicella-zoster virus (VZV), a neurotropic alpha herpes virus with a double-stranded DNA genome.
Lalu Muhammad Irham +10 more
doaj +2 more sources
[Retracted] Human Interferon Inducible Transmembrane Protein 3 (IFITM3) Inhibits Influenza Virus A Replication and Inflammation by Interacting with ABHD16A [PDF]
BioMed Research International, 2020 Studies have shown that human interferon inducible transmembrane protein (hIFITMs) family proteins have broad‐spectrum antiviral capabilities. Preliminary studies in our laboratory have tentatively proved that hIFITMs have the effect of inhibiting influenza viruses. In order to further study its mechanism and role in the occurrence
Liang Chen, Limei Zhu, Jun Chen
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Biochemistry, 2020 Lysophosphatidylserine (lyso-PS), a lysophospholipid derived from phosphatidylserine (PS), has emerged as a potent signaling lipid in mammalian physiology. In vivo, the metabolic serine hydrolases ABHD16A and ABHD12 are major lipases that biosynthesize and degrade lyso-PS, respectively.
Siddhesh Kamat +2 more
exaly +4 more sources
Single nucleotide polymorphism rs110861313 in the intergenic region of chromosome 23 is associated with the development of leukosis in the Russian Black Pied cattle [PDF]
Вавиловский журнал генетики и селекции, 2020 In recent years, using a genome-wide association study (GWAS), a number of single nucleotide polymorphisms (SNPs) have been suggested to be associated with susceptibility to leukemia in cattle.
R. B. Aitnazarov +6 more
doaj +2 more sources
Environmental Sciences EuropeAristolochic acid I (AA-I), a naturally occurring compound derived from plants of the genus Aristolochia, is a well-documented nephrotoxin and carcinogen linked to bladder (BLCA), kidney (KIRC), and liver (LIHC) cancers.
Bitian Zhang +3 more
doaj +2 more sources
Unraveling the Mechanism of ER-Associated Mitochondrial Fission and Fusion [PDF]
, 2022 Mitochondria are dynamic organelles that undergo cycles of fission and fusion at a unified platform defined by endoplasmic reticulum (ER)-mitochondria membrane contact sites (MCSs). These MCSs or nodes co-localize fission and fusion machinery.
Nguyen, Tricia Thuy-Trang
core +7 more sources