Results 21 to 30 of about 365 (96)

Splicing to keep splicing: A feedback system for cellular homeostasis and state transition. [PDF]

Clin Transl Med
ABSTRACT Background Alternative splicing (AS) plays a crucial role in regulating gene expression and governing proteomic diversity by generating multiple protein isoforms from a single gene. Increasing evidence has highlighted the regulation for pre‐mRNA splicing of the splicing factors (SFs).
Guo Z, Zhang X, Li Y, Chen Y, Xu Y.
europepmc   +2 more sources

Nerves Stimulate Cross-talk Between Gastric Cancer and Group 3 Innate Lymphoid Cells to Enhance Immunosuppression [PDF]

Cancer Research
Weixian Chen, Manran Liu, Siyang Wen
exaly   +2 more sources

Lipid‐correlated alterations in the transcriptome are enriched in several specific pathways in the postmortem prefrontal cortex of Japanese patients with schizophrenia

Neuropsychopharmacology Reports, Volume 43, Issue 3, Page 403-413, September 2023., 2023
This study investigated the link between gene expression and lipid abnormalities in schizophrenia. By analyzing postmortem prefrontal cortex samples, the researchers found alterations in gene expression associated with phosphoinositide 3‐kinase (PI3K)‐Akt signaling, the complement system, and ether lipid metabolism pathway.
Wataru Arihisa, Takeshi Kondo, Katsushi Yamaguchi, Junya Matsumoto, Hiroki Nakanishi, Yasuto Kunii, Hiroyasu Akatsu, Mizuki Hino, Yoshio Hashizume, Shumpei Sato, Shinji Sato, Shin‐Ichi Niwa, Hirooki Yabe, Takehiko Sasaki, Shuji Shigenobu, Mitsutoshi Setou   +15 more
wiley   +1 more source

Understanding and Targeting the Endocannabinoid System with Activity‐Based Protein Profiling

Israel Journal of Chemistry, Volume 63, Issue 3-4, March 2023., 2023
Abstract The endocannabinoid system (ECS) is a widespread modulatory system composed of cannabinoid receptors, endogenous signaling lipids termed endocannabinoids and the enzymes for the biosynthesis and degradation of these endocannabinoids. It plays a crucial role in diverse (patho)physiological functions, such as neurotransmission, neural ...
Na Zhu, Antonius P. A. Janssen, Mario van der Stelt   +2 more
wiley   +1 more source

Chemoproteomik‐basierte Identifikation von 4‐Oxo‐β‐lactamen als Inhibitoren der Dipeptidylpeptidasen 8 und 9

Angewandte Chemie, Volume 134, Issue 47, November 21, 2022., 2022
Die Entwicklung von Dipeptidylpeptidase 8‐ und 9‐ (DPP8/9)‐Inhibitoren mit hoher Selektivität ist eine große Herausforderung der Chemischen Biologie. Mithilfe von Aktivitäts‐basiertem Protein‐Profiling und Röntgenkristallstrukturanalyse konnten wir 4‐Oxo‐β‐lactame als potente, nicht‐Substrat‐artige nanomolare DPP8/9‐Inhibitoren mit unterschiedlichen ...
Luís A. R. Carvalho, Breyan Ross, Lorenz Fehr, Oguz Bolgi, Svenja Wöhrle, Kenneth M. Lum, David Podlesainski, Andreia C. Vieira, Reiner Kiefersauer, Rita Félix, Tiago Rodrigues, Susana D. Lucas, Olaf Groß, Ruth Geiss‐Friedlander, Benjamin F. Cravatt, Robert Huber, Markus Kaiser, Rui Moreira   +17 more
wiley   +1 more source

Chemoproteomics‐Enabled Identification of 4‐Oxo‐β‐Lactams as Inhibitors of Dipeptidyl Peptidases 8 and 9

Angewandte Chemie International Edition, Volume 61, Issue 47, November 21, 2022., 2022
Achieving Dipeptidyl Peptidase 8 and 9 (DPP8/9) selectivity is a current challenge in chemical biology. Supported by activity‐based protein profiling and X‐ray crystallography, we disclose 4‐oxo‐β‐lactams as potent, non‐substrate‐like nanomolar DPP8/9 inhibitors with different binding modes for DPP8/9, including an unprecedented targeting of an ...
Luís A. R. Carvalho, Breyan Ross, Lorenz Fehr, Oguz Bolgi, Svenja Wöhrle, Kenneth M. Lum, David Podlesainski, Andreia C. Vieira, Reiner Kiefersauer, Rita Félix, Tiago Rodrigues, Susana D. Lucas, Olaf Groß, Ruth Geiss‐Friedlander, Benjamin F. Cravatt, Robert Huber, Markus Kaiser, Rui Moreira   +17 more
wiley   +1 more source

Genomics4RD: An integrated platform to share Canadian deep‐phenotype and multiomic data for international rare disease gene discovery

Human Mutation, Volume 43, Issue 6, Page 800-811, June 2022., 2022
Here we present Genomics4RD, an integrated and internationally accessible web platform, to share, store, and visualize phenotypic and multiomic data from rare disease patients across Canada. Genomics4RD is connected to several other rare disease databases for the purposes of matchmaking and disease‐gene discovery.
Hannah G. Driver, Taila Hartley, E. Magda Price, Andrei L. Turinsky, Orion J. Buske, Matthew Osmond, Arun K. Ramani, Emily Kirby, Kristin D. Kernohan, Madeline Couse, Hillary Elrick, Kevin Lu, Pouria Mashouri, Aarthi Mohan, Delvin So, Conor Klamann, Hannah G. B. H. Le, Andrea Herscovich, Christian R. Marshall, Andrew Statia, Care4Rare Canada Consortium, Bartha M. Knoppers, Michael Brudno, Kym M. Boycott   +23 more
wiley   +1 more source

Identification of a novel homozygous synthesis of cytochrome c oxidase 2 variant in siblings with early‐onset axonal Charcot‐Marie‐Tooth disease

Human Mutation, Volume 43, Issue 4, Page 477-486, April 2022., 2022
Abstract The synthesis of cytochrome c oxidase 2 (SCO2) gene encodes for a mitochondrial located metallochaperone essential for the synthesis of the cytochrome c oxidase (COX) subunit 2. Recessive mutations in SCO2 have been reported in several cases with fatal infantile cardioencephalomyopathy with COX deficiency and in only four cases with axonal ...
Andrea Gangfuß, Andreas Hentschel, Nina Rademacher, Albert Sickmann, Burkhard Stüve, Rita Horvath, Claudia Gross, Nicolai Kohlschmidt, Fabian Förster, Angela Abicht, Anne Schänzer, Ulrike Schara‐Schmidt, Andreas Roos, Adela Della Marina   +13 more
wiley   +1 more source

Potential Impact of Cancer Susceptibility Genes on Lung Cancer Metastasis

Journal of Oncology, Volume 2022, Issue 1, 2022., 2022
Background. Studies of prognosis‐related molecular markers are an important tool to uncover the mechanism of tumour metastasis. Cancer susceptibility gene testing is an important tool for genetic counselling of cancer risk. However, the impact of lung cancer susceptibility genes (LCSGs) on lung cancer metastasis and prognosis has not been well studied.
Jiaqing Wang, Bin Peng, Xuefeng Sun, Peikun Ding, Shixuan Li, Guofeng Li, Xiaoshun Shi, Guangsuo Wang, Qin Yuan   +8 more
wiley   +1 more source

Data_Sheet_1_Pathogenic Variants in ABHD16A Cause a Novel Psychomotor Developmental Disorder With Spastic Paraplegia.docx

, 2021
Introduction: Hereditary spastic paraplegia is a clinically and genetically heterogeneous neurological entity that includes more than 80 disorders which share lower limb spasticity as a common feature.
Liena E. O. Elsayed (11305473), Muntaser E. Ibrahim (7936460), Mustafa A. Salih (8791694), Rawaa Adil (10166865), Arwa Babai (11305506), Fatima Abozar (11305494), Sara Emad (10166862), Isra Z. M. Eltazi (11305503), Ammar E. Ahmed (10166859), Mathilde Mairey (11305515), Giovanni Stevanin (115032), Foudil Lamari (837918), Elhami A. A. Ahmed (11305509), Alexis Brice (41775), Remi Valter (11305476), Inaam N. Mohammed (11305482), Mhammed Alhassan Musallam (11305497), Ahlam A. A. Hamed (11305479), Typhaine Esteves (11305488), Nicolas Auger (11305491), Rayan Abubaker (10166868), Ashraf Yahia (10166856), Maha A. Elseed (11305485), Mustafa I. Elbashir (11305521), Mahmoud Koko (4766814), Ahmed K. M. A. Ahmed (11305518), Hiba Malik (8478723), Razaz Idris (11305500), Amal S. I. Abd Allah (11305512)   +28 more
core   +1 more source