Results 71 to 80 of about 307,093 (281)
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Feminist Philosophy Quarterly, 2019 Analytic metaphysics of gender has taken an ameliorative turn towards ethical and political questions regarding what our concept of gender ought to be, and how gendered society should be structured.
Matthew J Cull
doaj +1 more source
The 10% tax rate: where next? [PDF]
, 2008 In Budget 2007, the Government announced the abolition of the 10% starting rate of income tax alongside a wider set of reforms to personal taxes and tax credits to take effect during the period April 2008 to April 2010. Further changes to tax credits and
Adam, S., Brewer, M., Chote, R.
core +1 more source
FEBS Open Bio, EarlyView.Excess Ca2+ ions activate the Calcium‐Sensing Receptor (CaSR), which subsequently drives the uptake of excess inorganic phosphate (Pi) via the Pi transporter (Pit−1) in chondrocytes. This mechanism causes a toxic increase in intracellular Pi concentration, ultimately leading to chondrocyte apoptosis and pathological mineralization. Excess extracellular
Sachie Nakatani +7 more
wiley +1 more source
Creating Momentum: The Atlantic Philanthropies' Investments to Repeal the Death Penalty in the United States [PDF]
, 2016 The Atlantic Philanthropies invested about $60 million between 2004 and 2016 to support efforts to repeal the death penalty in the United States. To assess the effectiveness of this work and to generate lessons for human rights activists and other ...
Kay E. Sherwood, Michael Quinn Patton
core
FEBS Open Bio, EarlyView.Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley +1 more source
Tempo Social, 1998 As obras de Perdigão Malheiros, Tavares Bastos e Joaquim Nabuco construírem um ideário sobre mudança social, no final do século XIX, significativamente expressivo e revelador de um modo singularizado de conceber o país e suas condições sociais ...
Maria José de Rezende
doaj +1 more source
Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276
FEBS Open Bio, EarlyView.Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig +7 more
wiley +1 more source
What Would Zero Look Like? A Treaty for the Abolition of Nuclear Weapons [PDF]
, 2014 Nuclear disarmament-the comprehensive, universal, and permanent abolition of all nuclear weapons, pursuant to a verifiable, legally binding international agreement-has long been one of the most ambitious, controversial, and urgent items on the agenda for
Koplow, David A
core +1 more source
Religion and Politics in Modern Britain [PDF]
, 2003 The appearance of J. R. Oldfield's study, Popular politics and British anti-slavery, first published by Manchester University Press in 1995, now in paperback and therefore available for a student market, is much to be welcomed.
Hall, C
core +1 more source