Results 101 to 110 of about 1,880,232 (279)

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

A deep learning model for brain age prediction using minimally preprocessed T1w images as input

Frontiers in Aging Neuroscience
IntroductionIn the last few years, several models trying to calculate the biological brain age have been proposed based on structural magnetic resonance imaging scans (T1-weighted MRIs, T1w) using multivariate methods and machine learning.
Caroline Dartora, Anna Marseglia, Gustav Mårtensson, Gull Rukh, Junhua Dang, J-Sebastian Muehlboeck, Lars-Olof Wahlund, Rodrigo Moreno, José Barroso, Daniel Ferreira, Daniel Ferreira, Helgi B. Schiöth, Eric Westman, Eric Westman, for the Alzheimer’s Disease Neuroimaging Initiative, the Australian Imaging Biomarkers and Lifestyle Flagship Study of Ageing, the Japanese Alzheimer’s Disease Neuroimaging Initiative, the AddNeuroMed Consortium   +17 more
doaj   +1 more source

The Second Paycheck to Keep Up With the Joneses: Relative Income Concerns and Labor Market Decisions of Married Women [PDF]

This paper investigates whether one’s effort to keep up with the Joneses has any effect on labor supply behavior. We provide a simple model and empirical evidence that labor supply decisions of married women are influenced by relative as well as absolute
Yongjin Park
core  

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

A Comparison of Automatic Bone Age Assessments between the Left and Right Hands: A Tool for Filtering Measurement Errors

Applied Sciences
This study aimed to investigate whether the left and right hands yield the same bone age using the automated bone age assessment (BAA) system and proposed the right-hand BAA as a tool for filtering out measurement errors. The Bland–Altman, Passing–Bablok,
Kyu-Chong Lee, Chang Ho Kang, Kyung-Sik Ahn, Kee-Hyoung Lee, Jae Joon Lee, Kyu Ran Cho, Saelin Oh   +6 more
doaj   +1 more source

Absolute quantification of plasma IgG N-glycopeptides as a biomarker for diagnosis of the early COPD [PDF]

Jichu yixue yu linchuang
Objective To investigate the potential of the absolute quantifaction of plasma IgG N-glycopeptides for the early diagnosis of chronic obstructive pulmonary disease (COPD).
LIU Zhaoyi, YIN Meiling, WANG Lin, ZHOU Jinyu
doaj   +1 more source

The SLoWPoKES Catalog of Low-mass Ultra-wide Binaries: A Cool Stars Resource for Testing Fundamental Properties and for Constraining Binary Formation Theory

, 2012
We present results from the Sloan Low-mass Wide Pairs of Kinematically Equivalent Stars (SLoWPoKES) catalog of ultra-wide (10^3-10^5.5 AU), low-mass (K5-M7) common proper motion binaries. We constructed a Galactic model, based on empirical stellar number
Abazajian, Bate, Bate, Bochanski, Bochanski, Cartwright, Chanamé, Connelley, Dhital, Dhital, Duquennoy, Fischer, Hauschildt, Jiang, Jurić, Kouwenhoven, Kraus, Kraus, Law, Lépine, Lépine, Moeckel, Moeckel, Morgan, Munn, Parker, Reid, Rojas-Ayala, Schmidt, Stassun, Terrien, Tokovinin, Weinberg, West, Woolf   +34 more
core   +1 more source

Hospital Readmission After Traumatic Brain Injury Hospitalization in Community‐Dwelling Older Adults

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the risk of hospital readmission after an index hospitalization for TBI in older adults. Methods Using data from the Atherosclerosis Risk in Communities (ARIC) study, we used propensity score matching of individuals with an index TBI‐related hospitalization to individuals with (1) non‐TBI hospitalizations (primary analysis)
Rachel Thomas, Connor A. Law, Joan A. Casey, Thomas Mosley, Rebecca F. Gottesman, Ramon Diaz‐Arrastia, Holly Elser, Andrea L. C. Schneider   +7 more
wiley   +1 more source

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source