Results 91 to 100 of about 1,880,232 (279)

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Individualised prediction of major bleeding in patients with atrial fibrillation treated with anticoagulation.

PLoS ONE
BackgroundAnticoagulation in atrial fibrillation (AF) increases the risk of major bleeding. No predictive model has hitherto provided estimates of the absolute risk for individual patients.AimTo predict the individual 1-year risk of major bleeding in ...
Anne Pernille Toft-Petersen, Christina J-Y Lee, Matthew Phelps, Brice Ozenne, Thomas Alexander Gerds, Christian Torp-Pedersen   +5 more
doaj   +1 more source

Detection of a Stellar Stream Behind Open Cluster NGC 188: Another Part of the Monoceros Stream

, 2010
We present results from a WIYN/OPTIC photometric and astrometric survey of the field of the open cluster NGC 188 ((l,b) = (122.8\arcdeg, 22.5\arcdeg)). We combine these results with the proper-motion and photometry catalog of Platais et al.
Casetti-Dinescu, Casetti-Dinescu, Casetti-Dinescu, Conn, Dana I. Casetti-Dinescu, Dotter, Gawiser, Ibata, Imants Platais, Ivezić, Jurić, Majewski, Majewski, Meibom, Newberg, Peñarrubia, Platais, Rocha-Pinto, Sarajedini, Taylor, Terrence M. Girard, VandenBerg, Vivas, von Hippel, William F. van Altena, Yanny   +25 more
core   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

The descriptive epidemiology and projection of liver cancer in adolescents and young adults: findings from the global burden of disease study 2021

Frontiers in Medicine
BackgroundThe global burden of liver cancer among adolescents and young adults (AYAs, 15–39 years) is an emerging concern. This study analyzes epidemiological trends from 1990 to 2021 and projects future burden to 2030 to inform prevention strategies ...
Kai Yang, Meicen Liu, Ke Xu
doaj   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Age estimation by pulp to tooth area ratio in canine teeth using cone-beam computed tomography

Egyptian Journal of Forensic Sciences, 2020
Background This study aimed to estimate the chronological age of individuals according to the correlation of age with morphological variables of the maxillary canine teeth using cone-beam computed tomography (CBCT) based on Kvaal’s method.
Fatemeh Salemi, Maryam Farhadian, Bahare Askari Sabzkouhi, Samira Saati, Nika Nafisi   +4 more
doaj   +1 more source

A catch-free stock assessment model with application to goliath grouper (Epinephelus itajara) off southern Florida [PDF]

, 2006
Many modern stock assessment methods provide the machinery for determining the status of a stock in relation to certain reference points and for estimating how quickly a stock can be rebuilt. However, these methods typically require catch data, which are
Eklund, Anne-Marie, Porch, Clay E., Scott, Gerald P.   +2 more
core