Results 71 to 80 of about 1,880,232 (279)

High-scale validity of a two Higgs doublet scenario: metastability included [PDF]

, 2016
We make an attempt to identify regions in a Type II Two-Higgs Doublet Model, which correspond to a metastable electroweak vacuum with lifetime larger than the age of the universe.
Chakrabarty, Nabarun, Mukhopadhyaya, Biswarup   +1 more
core   +2 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Structure and Mass of a Young Globular Cluster in NGC 6946 [PDF]

, 2001
Using the Wide Field Planetary Camera 2 on board the Hubble Space Telescope, we have imaged a luminous young star cluster in the nearby spiral galaxy NGC 6946.
Brodie, J. P., Efremov, Y. N., Elmegreen, B. G., Hodge, P. W., Larsen, S. S., Richtler, T.   +5 more
core   +2 more sources

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

The triple A model-AAA (age, absolute neutrophil count, absolute lymphocyte count) predicts survival and thrombosis in polycythemia vera

HemaSphere
Background: In 2023, the triple A prognostic model-AAA (Age, Absolute neutrophil count-ANC and absolute lymphocyte count-ALC) developed by the Mayo Clinic has been shown to excellently predict overall survival (OS) in patients with essential thrombocythemia.
Krečak, Ivan, Lucijanić, Marko, Holik, Hrvoje   +2 more
openaire   +1 more source

Remaining lifetime and absolute 10-year probabilities of osteoporotic fracture in Swiss men and women [PDF]

, 2018
Summary: Remaining lifetime and absolute 10-year probabilities for osteoporotic fractures were determined by gender, age, and BMD values. Remaining lifetime probability at age 50years was 20.2% in men and 51.3% in women and increased with advancing age ...
Johansson, H., Kanis, J., Lippuner, K., Rizzoli, R.   +3 more
core  

The Age, Stellar Content and Star Formation Timescale of the B59 Dense Core

, 2010
We have used moderate resolution, near-infrared spectra from the SpeX spectrograph on the NASA Infrared Telescope facility to characterize the stellar content of Barnard 59 (B59), the most active star-forming core in the Pipe Nebula. Measuring luminosity
A. A. Muench, Allers, Allers, Aspin, Ballesteros-Paredes, Baraffe, Barnard, Brooke, C. J. Lada, C. Román-Zúñiga, Carpenter, Cieza, Covey, Covey, Crutcher, Cushing, Doppmann, Elmegreen, Forbrich, Forbrich, Geballe, Gorlova, Hartmann, Herbig, Hillenbrand, Indebetouw, Ivanov, J. Ascenso, J. Forbrich, K. R. Covey, Kenyon, Klessen, Krumholz, Lada, Lada, Luhman, Luhman, Luhman, Luhman, Luhman, Luhman, Matzner, McLean, Mentuch, Meyer, Morales-Calderón, Mouschovias, Muench, Muench, Nakamura, Nakano, Offner, Offner, Onishi, Rathborne, Rathborne, Rayner, Reid, Reipurth, Riaz, Román-Zúñiga, Román-Zúñiga, Slesnick, Swift, Swift, Takagi, Tan, The, Troland, Vázquez-Semadeni, Vázquez-Semadeni, Wallace, Wilking, Wilking, Williams   +74 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Modelling early-type stars in eclipsing binaries of open clusters: a new method for age determination from ratio of radii

, 2011
Binary systems, in particular eclipsing binaries, are essential sources of our knowledge of the fundamental properties of stars. The ages of binaries, members of open clusters, are constrained by their own fundamental properties and by those of the ...
Yildiz, Mutlu
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source