Results 51 to 60 of about 1,880,232 (279)

Global, regional, and national burden of spinal cord lesion at neck level a systematic analysis of incidence, prevalence, YLDs with projections to 2046

Frontiers in Public Health
BackgroundSpinal cord lesion at neck level imposes significant global morbidity, yet cervical-specific burden analysis remains limited.MethodsUsing Global Burden of Disease (GBD) 2021 data (1990–2021), we analyzed incidence, prevalence, and years lived ...
Yi Zhang, Weilun Zhao, Xiaoming Peng, Xiaoming Peng, Fayun Yang, Shaohui Zong, Shaohui Zong   +6 more
doaj   +1 more source

iCARE: An R package to build, validate and apply absolute risk models. [PDF]

PLoS ONE, 2020
This report describes an R package, called the Individualized Coherent Absolute Risk Estimator (iCARE) tool, that allows researchers to build and evaluate models for absolute risk and apply them to estimate an individual's risk of developing disease ...
Parichoy Pal Choudhury, Paige Maas, Amber Wilcox, William Wheeler, Mark Brook, David Check, Montserrat Garcia-Closas, Nilanjan Chatterjee   +7 more
doaj   +1 more source

The 0.4-Mo Eclipsing Binary CU Cancri: Absolute Dimensions, Comparison with Evolutionary Models and Possible Evidence for a Circumstellar Dust Disk [PDF]

, 2002
Photometric observations in the R and I bands of the detached M-type double-lined eclipsing binary CU Cnc have been acquired and analysed. The photometric elements obtained from the analysis of the light curves have been combined with an existing ...
Allard, Allard, Andersen, Anosova, Baraffe, Barrado y Navascués, Barrado y Navascués, Barrado y Navascués, Bergbusch, Bessell, Bessell, Bessell, Bodenheimer, Carpenter, Cayrel de Strobel, Charbonnel, Claret, Claret, Cousins, D'Antona, D'Antona, Delfosse, Delfosse, Duncan, Edvardsson, Elias, Elias, Fitzpatrick, Forveille, Gagne, Girardi, Granzer, Greaves, Güdel, Hatzes, Hauschildt, Holland, I. Ribas, Jeffries, Klinglesmith, Leggett, Leggett, Lejeune, Maceroni, Martin, Mazeh, Metcalfe, Milone, Palla, Pavlenko, Ribas, Schmitt, Siess, Soderblom, Soderblom, Stauffer, Swenson, Ségransan, Torres, Voges, Weis, Wilson, Yi, Young   +63 more
core   +2 more sources

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Development and validation of a risk prediction model for premenopausal breast cancer in 19 cohorts

Breast Cancer Research
Background Incidence of premenopausal breast cancer (BC) has risen in recent years, though most existing BC prediction models are not generalizable to young women due to underrepresentation of this age group in model development.
Kristen D. Brantley, Michael E. Jones, Rulla M. Tamimi, Bernard A. Rosner, Peter Kraft, Hazel B. Nichols, Katie M. O’Brien, Hans-Olov Adami, Amaia Aizpurua, Amy Berrington de González, William J. Blot, Tonje Braaten, Yu Chen, Jessica Clague DeHart, Laure Dossus, Sjoerd Elias, Renée T. Fortner, Montserrat Garcia-Closas, Inger T. Gram, Niclas Håkansson, Susan E. Hankinson, Cari M. Kitahara, Woon-Puay Koh, Martha S. Linet, Robert J. MacInnis, Giovanna Masala, Lene Mellemkjær, Roger L. Milne, David C. Muller, Hannah Lui Park, Kathryn J. Ruddy, Sven Sandin, Xiao-Ou Shu, Sandar Tin Tin, Thérèse Truong, Celine M. Vachon, Lars J. Vatten, Kala Visvanathan, Elisabete Weiderpass, Walter Willett, Alicja Wolk, Jian-Min Yuan, Wei Zheng, Dale P. Sandler, Minouk J. Schoemaker, Anthony J. Swerdlow, A. Heather Eliassen   +46 more
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Age-Related Changes in Resting-State EEG Activity in Attention Deficit/Hyperactivity Disorder: A Cross-Sectional Study

Frontiers in Human Neuroscience, 2017
Numerous studies indicate that attention deficit/hyperactivity disorder (ADHD) is related to some developmental trends, as its symptoms change widely over time. Nevertheless, the etiology of this phenomenon remains ambiguous.
Katarzyna Giertuga, Marta Z. Zakrzewska, Maksymilian Bielecki, Ewa Racicka-Pawlukiewicz, Malgorzata Kossut, Malgorzata Kossut, Anita Cybulska-Klosowicz   +6 more
doaj   +1 more source

Survival prediction in mesothelioma using a scalable lasso regression model: instructions for use and initial performance using clinical predictors [PDF]

, 2018
Introduction: Accurate prognostication is difficult in malignant pleural mesothelioma (MPM). We developed a set of robust computational models to quantify the prognostic value of routinely available clinical data, which form the basis of published MPM ...
Blyth, Kevin G., Bylesjo, Max, Halligan, Daniel L., Kidd, Andrew C., McGettrick, Michael, Tsim, Selina   +5 more
core   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source