Results 261 to 270 of about 162,999 (382)

Neurophysiological Effect of Transcutaneous Electrical Spinal Cord Stimulation in Chronic Complete Spinal Cord Injury

open access: yesArtificial Organs, EarlyView.
TESCS‐ABT induced neurophysiological changes in individuals with chronic complete SCI, however these did not consistently translate into functional improvements. These findings highlight the role of residual supraspinal connectivity and inform future research to optimise this neurotechnology for SCI rehabilitation and identify likely responders ...
E. L. McNicol   +6 more
wiley   +1 more source

Targeting MCL‐1 and MAPK overcomes venetoclax resistance in FLT3‐ITD‐positive AML cells harbouring activating PTPN11 (SHP‐2) mutations

open access: yesBritish Journal of Haematology, EarlyView.
Summary Venetoclax (VEN)‐based therapies have improved the treatment of acute myeloid leukaemia (AML); however, the emergence of resistance remains a major limitation. Mutations in protein tyrosine phosphatase (PTP) non‐receptor type 11 (PTPN11) and FMS like tyrosine kinase 3 with internal tandem duplication (FLT3‐ITD) are common in resistant patients ...
Maximilian Fleischmann   +12 more
wiley   +1 more source

Selective small molecule targeting of KDM4 as a therapeutic strategy to reduce proliferation of acute myeloid leukaemia

open access: yesBritish Journal of Haematology, EarlyView.
Summary Acute myeloid leukaemia (AML) is an aggressive disease with poor survival and high relapse rates. Coupled with the complex mutational burden observed, there is an unmet clinical need for more targeted therapies. Epigenetic therapies have shown promise both as monotherapy and in combination strategies and specifically histone lysine demethylase,
Laura Monaghan   +10 more
wiley   +1 more source

Preclinical models for evaluating psychedelics in the treatment of major depressive disorder

open access: yesBritish Journal of Pharmacology, EarlyView.
Psychedelic drugs have seen a resurgence in interest as a next generation of psychiatric medicines with potential as rapid‐acting antidepressants (RAADs). Despite promising early clinical trials, the mechanisms which underlie the effects of psychedelics are poorly understood.
Laith Alexander   +5 more
wiley   +1 more source

Multi-Response Modeling for Bio-Compound Ultrasound-Assisted Extraction (UAE) from Matico (<i>Piper aduncum</i> L.) and Chacruna (<i>Psychotria viridis</i> Ruiz & Pav.) Leaves Originating in the Peruvian Amazon. [PDF]

open access: yesMolecules
Rafael-Saldaña R   +7 more
europepmc   +1 more source

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