Results 61 to 70 of about 464,371 (256)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Possible Charge-Exchange X-Ray Emission in the Cygnus Loop Detected with Suzaku [PDF]

, 2011
X-ray spectroscopic measurements of the Cygnus Loop supernova remnant indicate that metal abundances throughout most of the remnant's rim are depleted to about 0.2 times the solar value.
Hewitt, John W., Katsuda, Satoru, Kimura, Masashi, Kosugi, Hiroko, Mori, Koji, Nakajima, Hiroshi, Petre, Robert, Takakura, Satoru, Tsunemi, Hiroshi, Uchida, Hiroyuki, Yamaguchi, Hiroya   +10 more
core   +3 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Planetary nebulae in the inner Milky Way: new abundances [PDF]

, 2009
The study of planetary nebulae in the inner-disk and bulge gives important information on the chemical abundances of elements such as He, N, O, Ar, Ne, and on the evolution of these abundances, which is associated with the evolution of intermediate-mass ...
Cavichia, O., Costa, R. D. D., Maciel, W. J.   +2 more
core   +2 more sources

Galactic Abundances: Report of Working Group 3 [PDF]

, 2001
We summarize the various methods and their limitations and strengths to derive galactic abundances from in-situ and remote-sensing measurements, both from ground-based observations and from instruments in space. Because galactic abundances evolve in time
Bothmer, V., Buclin, F., Christian, E. R., Cummings, A. C., Flückiger, E. O., George, J. S., Hofer, M. Y., Jones, F. C., Keller, J. W., Kirilova, D., Klecker, B., Kunow, H., Laming, M., Salerno, E., Sofia, U. J., Stone, E. C., Thielemann, F.-K., Tranquille, C., Wenzel, K.-P., Wiedenbeck, M. E.   +19 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Chemical evolution and kilonova implications of post-merger accretion disk winds

Astronomy & Astrophysics
Context. Several gamma-ray bursts (GRBs) have recently been associated with kilonova emission. We study the mechanisms that account for this effect by means of the radioactive decay of elements synthesized in accretion disk winds. Aims.
Janiuk Agnieszka, Saji Joseph, Urrutia Gerardo   +2 more
doaj   +1 more source

Chemical composition of A and F dwarfs members of the Pleiades open cluster

, 2008
Abundances of 18 chemical elements have been derived for 16 A (normal and chemically peculiar CP) and 5 F dwarfs members of the Pleiades open cluster in order to set constraints on evolutionary models.
Abt, Baranne, Boesgaard, Boesgaard, Bounatiro, Breger, Burkhart, Castelli, Conti, Couteau, Dommanget, Erspamer, Ford, Friel, Gebran, Gray, Grevesse, Hauck, Hill, Hubeny, Hui-Bon-Hoa, Kurucz, Lemke, M. Gebran, Meynet, Monier, Moon, Napiwotzki, Percival, Pilachowski, R. Monier, Renson, Richer, Smalley, Takeda, Turcotte, Varenne, Zahn   +37 more
core   +2 more sources

Chemical Abundances in AGN Environment: X-Ray/UV Campaign on the MRK 279 Outflow [PDF]

, 2006
We present the first reliable determination of chemical abundances in an AGN outflow. The abundances are extracted from the deep and simultaneous FUSE and HST/STIS observations of Mrk 279.
Ari Laor, C. Martin Gaskell, C. Nalaka Kodituwakku, Daniel Proga, Dietrich M., Ehud Behar, Elisa Costantini, Gerard A. Kriss, Jack R. Gabel, Jelle S. Kaastra, Jennifer E. Scott, Kaastra J. S., Katrien C. Steenbrugge, Kirk T. Korista, Masao Sako, Nahum Arav   +15 more
core   +3 more sources

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source