Results 71 to 80 of about 278,007 (307)

Practitioner Track Proceedings of the 6th International Learning Analytics & Knowledge Conference (LAK16) [PDF]

open access: yes, 2016
Practitioners spearhead a significant portion of learning analytics, relying on implementation and experimentation rather than on traditional academic research. Both approaches help to improve the state of the art.

core  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Creating business value from big data and business analytics : organizational, managerial and human resource implications [PDF]

open access: yes, 2014
This paper reports on a research project, funded by the EPSRC’s NEMODE (New Economic Models in the Digital Economy, Network+) programme, explores how organizations create value from their increasingly Big Data and the challenges they face in doing so ...
Vidgen, Richard T
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Sparking institutional change: The experience of implementing a Learning Analytics project in an online university

open access: yesUbiquity Proceedings
Learning analytics have gained relevance in online higher education over the last decade, focusing on supporting teaching and learning processes while enhancing students’ academic performance.
José Israel Reyes   +3 more
doaj   +1 more source

Analytics and complexity: learning and leading for the future [PDF]

open access: yes, 2012
There is growing interest in the application of learning analytics to manage, inform and improve learning and teaching within higher education. In particular, learning analytics is seen as enabling data-driven decision making as universities are seeking ...
Beer, Colin, Clark, Damien, Jones, David
core   +1 more source

Understanding research dynamics [PDF]

open access: yes, 2014
Rexplore leverages novel solutions in data mining, semantic technologies and visual analytics, and provides an innovative environment for exploring and making sense of scholarly data. Rexplore allows users: 1) to detect and make sense of important trends
Motta, Enrico, Osborne, Francesco
core   +3 more sources

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

Rexplore: unveiling the dynamics of scholarly data [PDF]

open access: yes, 2014
Rexplore is a novel system that integrates semantic technologies, data mining techniques, and visual analytics to provide an innovative environment for making sense of scholarly data.
Motta, Enrico, Osborne, Francesco
core   +2 more sources

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

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