Results 81 to 90 of about 55,672 (306)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

AI‐based intra‐tumor heterogeneity score of Ki67 expression as a prognostic marker for early‐stage ER+/HER2− breast cancer

The Journal of Pathology: Clinical Research
Early‐stage estrogen receptor positive and human epidermal growth factor receptor negative (ER+/HER2−) luminal breast cancer (BC) is quite heterogeneous and accounts for about 70% of all BCs.
Wenqi Lu, Ayat G Lashen, Noorul Wahab, Islam M Miligy, Mostafa Jahanifar, Michael Toss, Simon Graham, Mohsin Bilal, Abhir Bhalerao, Nehal M Atallah, Shorouk Makhlouf, Asmaa Y Ibrahim, David Snead, Fayyaz Minhas, Shan E Ahmed Raza, Emad Rakha, Nasir Rajpoot   +16 more
doaj   +1 more source

Exploring learning analytics as indicators of study behaviour

, 2012
In this paper we describe the use of learning analytics to provide indicators of students’ behaviour in technology-enhanced learning environments. We first provide an overview of the emerging field of learning analytics, and then describe a learning ...
Phillips, R., Preston, G., Maor, D., Cumming-Potvin, W.   +3 more
core  

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Cell trajectory modulation: rapid microfluidic biophysical profiling of CAR T cell functional phenotypes

Nature Communications
Chimeric Antigen Receptor (CAR) T cell therapy is a pivotal treatment for hematological malignancies. However, CAR T cell products exhibit batch-to-batch variability in cell number, quality, and in vivo efficacy due to donor-to-donor heterogeneity, and ...
Kerwin Kwek Zeming, Kai Yun Quek, Wei-Xiang Sin, Denise Bei Lin Teo, Ka-Wai Cheung, Chin Ren Goh, Faris Kairi, Elizabeth Lee, Francesca Lorraine Wei Inng Lim, Michaela Su-Fern Seng, Shui Yen Soh, Michael E. Birnbaum, Jongyoon Han   +12 more
doaj   +1 more source

Learning analytics and study behaviour: A pilot study

, 2011
The analysis of student access to learning management systems and web-based lecture capture systems is a growing area of interest for teachers in higher education wishing to improve the student learning experience.
Herrington, J., Phillips, R., Roberts, P., Moore, E., Preston, G., Maor, D., Cumming-Potvin, W., Perry, L.   +7 more
core  

Improving Learning Analytics and Student Performance through Connected Lifelong Learning on the Blockchain [PDF]

, 2020
[LAK’20: 10th International Learning Analytics and Knowledge] 23-27 March 2020; The University of Frankfurt, Frankfurt, GermanyThe use of learning analytics to enhance learning at different levels has continued to gain attention over the past few years ...
Ogata, Hiroaki, Lecailliez, Louis, Ocheja, Patrick, Flanagan, Brendan   +3 more
core  

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Association of Altered Plasma Lipidome with Disease Severity in COVID-19 Patients

Biomolecules
The severity of COVID-19 is linked to an imbalanced immune response. The dysregulated metabolism of small molecules and bioactive lipids has also been associated with disease severity.
Zhengzheng Zhang, Naama Karu, Alida Kindt, Madhulika Singh, Lieke Lamont, Adriaan J. van Gammeren, Anton A. M. Ermens, Amy C. Harms, Lutzen Portengen, Roel C. H. Vermeulen, Willem A. Dik, Anton W. Langerak, Vincent H. J. van der Velden, Thomas Hankemeier   +13 more
doaj   +1 more source

Use of Learning Analytics in K–12 Mathematics Education : Systematic Scoping Review of the Impact on Teaching and Learning

The generation, use, and analysis of educational data comes with many promises and opportunities, especially where digital materials allow usage of learning analytics (LA) as a tool in data-based decision-making (DBDM). However, there are questions about
Masiello, Italo, Masiello, Italo,, Mohseni, Zeynab,, Rack, John, Mohseni, Zeynab, Rack, John,, Rundquist, Rebecka,, Holmberg, Kristina, Holmberg, Kristina,, Rundquist, Rebecka   +9 more
core   +1 more source