Results 81 to 90 of about 278,007 (307)

AI‐based intra‐tumor heterogeneity score of Ki67 expression as a prognostic marker for early‐stage ER+/HER2− breast cancer

The Journal of Pathology: Clinical Research
Early‐stage estrogen receptor positive and human epidermal growth factor receptor negative (ER+/HER2−) luminal breast cancer (BC) is quite heterogeneous and accounts for about 70% of all BCs.
Wenqi Lu, Ayat G Lashen, Noorul Wahab, Islam M Miligy, Mostafa Jahanifar, Michael Toss, Simon Graham, Mohsin Bilal, Abhir Bhalerao, Nehal M Atallah, Shorouk Makhlouf, Asmaa Y Ibrahim, David Snead, Fayyaz Minhas, Shan E Ahmed Raza, Emad Rakha, Nasir Rajpoot   +16 more
doaj   +1 more source

Innovating for Learning: Designing for the Future of Education [PDF]

, 2015
Teaching has moved online as the world has moved online and learning is losing its sense of physical location with the availability of many different options from mobile to MOOC (Massive Open Online Course).
McAndrew, Patrick
core  

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Cell trajectory modulation: rapid microfluidic biophysical profiling of CAR T cell functional phenotypes

Nature Communications
Chimeric Antigen Receptor (CAR) T cell therapy is a pivotal treatment for hematological malignancies. However, CAR T cell products exhibit batch-to-batch variability in cell number, quality, and in vivo efficacy due to donor-to-donor heterogeneity, and ...
Kerwin Kwek Zeming, Kai Yun Quek, Wei-Xiang Sin, Denise Bei Lin Teo, Ka-Wai Cheung, Chin Ren Goh, Faris Kairi, Elizabeth Lee, Francesca Lorraine Wei Inng Lim, Michaela Su-Fern Seng, Shui Yen Soh, Michael E. Birnbaum, Jongyoon Han   +12 more
doaj   +1 more source

Association of Altered Plasma Lipidome with Disease Severity in COVID-19 Patients

Biomolecules
The severity of COVID-19 is linked to an imbalanced immune response. The dysregulated metabolism of small molecules and bioactive lipids has also been associated with disease severity.
Zhengzheng Zhang, Naama Karu, Alida Kindt, Madhulika Singh, Lieke Lamont, Adriaan J. van Gammeren, Anton A. M. Ermens, Amy C. Harms, Lutzen Portengen, Roel C. H. Vermeulen, Willem A. Dik, Anton W. Langerak, Vincent H. J. van der Velden, Thomas Hankemeier   +13 more
doaj   +1 more source

A Multiple Study Investigation of the Evaluation Framework for Learning Analytics: Instrument Validation and the Impact on Learner Performance

Educational Technology & Society, 2021
The purposes of the two studies reported in this research are to adapt and validate the instrument of the Evaluation Framework for Learning Analytics (EFLA) for learners into the Turkish context, and to examine how metacognitive and behavioral factors ...
Mehmet Kokoç, Mehmet Kara
doaj  

The Potential for Student Performance Prediction in Small Cohorts with Minimal Available Attributes [PDF]

, 2019
The measurement of student performance during their progress through university study provides academic leadership with critical information on each student’s likelihood of success.
Ashraf A., Choi S. P., Corrin L., HESA, Heuer H., Horning N., Quinlan J. R., Rienties B., Rienties B., Sclater N., Slade S., Wakelam E.   +11 more
core   +2 more sources

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Academic Analytics - Zur Bedeutung von (Big) Data Analytics in der Evaluation

, 2017
Im Kontext der Hochschul- und Bildungsforschung wird Evaluation in ihrer Gesamtheit als Steuerungs- und Controlling-Instrument eingesetzt, um unter anderem Aussagen zur Qualität von Lehre, Forschung und Administration zu liefern. Auch wenn der Qualitätsbegriff an den Hochschulen bislang noch immer sehr unterschiedlich geführt wird, verfolgen die ...
openaire   +2 more sources

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source